High prevalence of A-B+ ketosis-prone diabetes in children with type 2 diabetes and diabetic ketoacidosis at diagnosis: Evidence from the Rare and Atypical Diabetes Network (RADIANT)

Authors: KUBOTA-MISHRA, ELIZABETH - Baylor College Of Medicine; HUANG, XIAOFAN - Baylor College Of Medicine; MINARD, CHARLES - Baylor College Of Medicine; ASTUDILLO, MARCELA - Baylor College Of Medicine; REFAEY, AHMAD - University Of Houston; MONTES, GRACIELA - Baylor College Of Medicine; SISLEY, STEPHANIE - Children'S Nutrition Research Center (CNRC); RAM, NALINI - Baylor College Of Medicine; WINTER, WILLIAM - University Of Florida; NAYLOR, ROCHELLE - University Of Chicago; BALASUBRAMANYAM, ASHOK - Baylor College Of Medicine; REDONDO, MARIA - Baylor College Of Medicine; TOSUR, MUSTAFA - Children'S Nutrition Research Center (CNRC)

Submitted to: Pediatric Diabetes
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/13/2024
Publication Date: 3/4/2024
Citation: Kubota-Mishra, E., Huang, X., Minard, C.G., Astudillo, M., Refaey, A., Montes, G., Sisley, S., Ram, N., Winter, W.E., Naylor, R.N., Balasubramanyam, A., Redondo, M.J., Tosur, M., and RADIANT Study Group. 2024. High prevalence of A-B+ ketosis-prone diabetes in children with type 2 diabetes and diabetic ketoacidosis at diagnosis: Evidence from the Rare and Atypical Diabetes Network (RADIANT). Pediatric Diabetes. Article 5907924. https://doi.org/10.1155/2024/5907924.
DOI: https://doi.org/10.1155/2024/5907924

Interpretive Summary: Not all diabetes are the same. A special type, called ketosis-prone diabetes (KPD), is hard to distinguish from type 2 diabetes but often needs different treatment. Researchers in Houston, Texas looked at 716 kids with type 2 diabetes and found that half of the 56 who were diagnosed with diabetes due to a serious problem called diabetic ketoacidosis (DKA) had KPD. These kids with KPD were mostly boys, mostly African American or Hispanic, and their bodies could still make some insulin. This helps researchers understand that some kids who look like they have regular type 2 diabetes may actually have KPD, which could change the interventions used to help them get healthier.

Technical Abstract: A-B+ ketosis-prone diabetes (KPD) in adults is characterized by presentation with diabetic ketoacidosis (DKA), negative islet autoantibodies, and preserved B-cell function in persons with a phenotype of obesity-associated type 2 diabetes (T2D). The prevalence of KPD has not been evaluated in children. We investigated children with DKA at “T2D” onset and determined the prevalence and characteristics of pediatric A-B+ KPD within this cohort. We reviewed the records of 716 children with T2D at a large academic hospital and compared clinical characteristics of those with and without DKA at onset. In the latter group, we identified patients with A-B+ KPD using criteria of the Rare and Atypical Diabetes Network (RADIANT) and defined its prevalence and characteristics. Mean age at diagnosis was 13.7 +/- 2.4 years: 63% female; 59% Hispanic, 29% African American, 9% non-Hispanic White, and 3% other. Fifty-six (7.8%) presented with DKA at diagnosis and lacked islet autoantibodies. Children presenting with DKA were older and had lower C-peptide and higher glucose concentrations than those without DKA. Twenty-five children with DKA (45%) met RADIANT A-B+ KPD criteria. They were predominantly male (64%), African American or Hispanic (96%), with substantial C-peptide (1.3 +/- 0.7 ng/mL) at presentation with DKA and excellent long-term glycemic control (HbA1c 6.6% +/- 1.9% at follow-up (median 1.3 years postdiagnosis)). In children with a clinical phenotype of T2D and DKA at diagnosis, approximately half meet criteria for A-B+ KPD. They manifest the key characteristics of obesity, preserved B-cell function, male predominance, and potential to discontinue insulin therapy, similar to adults with A-B+ KPD.