Trichinella: Becoming a parasite

Authors: ZARLENGA, DANTE - Former ARS Employee; HOBERG, ERIC - Former ARS Employee; Thompson, Peter; Rosenthal, Benjamin

Submitted to: Veterinary Parasitology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 6/3/2024
Publication Date: 6/13/2024
Citation: Zarlenga, D.S., Hoberg, E.P., Thompson, P.C., Rosenthal, B.M. 2024. Trichinella: Becoming a parasite. Veterinary Parasitology. Article e110220. https://doi.org/10.1016/j.vetpar.2024.110220.
DOI: https://doi.org/10.1016/j.vetpar.2024.110220

Interpretive Summary: Trichinella no longer poses appreciable risk to American pork consumers but continues to circulate in wildlife. These and other parasitic nematodes evolved from free-living ancestors. Here, USDA scientists in Beltsville, MD explored what may have enabled them to thrive in otherwise inhospitable host tissues. They discovered that parasitic nematodes share a unique feature: the ability to detoxify ammonia, employing an enzyme called cyanase. This insight will interest those interested in devising better tools to prevent and treat infections, as well as those more broadly interested in the evolution of parasitism.

Technical Abstract: Phylogenetic evidence indicates that free-living nematodes gave rise to parasitic nematodes where parasitism evolved independently at least 15 times. The high level of genetic and biological diversity among parasites dictates an equally high level of diversity in the transition to parasitism. We previously hypothesized that horizontal gene transfer (HGT) played an important role in the evolution of parasitism among early ancestors of Trichinella, mediated by an interplay of ecological and evolutionary pathways that contributed to persistence and diversification. We propose that host selection may have been associated with the metabolism of ammonia and engender a new paradigm whereby the reprogrammed nurse cell is capable of generating cyanate thereby enabling the importance of the Trichinella cyanase in the longevity of the cell. Parasites and parasitism have revealed considerable resilience against a backdrop of climate change and environmental perturbation. Here we provide a putative link between key periods in the evolution of Trichinella and major geological and climatological events dating back 500 million years. A useful lens for exploring such ideas, the Stockholm Paradigm, integrates Ecological Fitting (a foundation for host colonization and diversification), the Oscillation Hypothesis (recurring shifts between trends in generalization and specialization relative to host range), the Geographic Mosaic Theory of Coevolution (microevolutionary co-adaptive processes), and the Taxon Pulse Hypothesis (alternating events of biotic expansion i.e., exploitation in evolutionary and ecological time). Here we examine how one or more of these interactive theories, in a phylogenetic-historical context and in conjunction with HGT, may help explain the scope and depth of diversity among Trichinella genotypes.