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ARS Home » Plains Area » Kerrville, Texas » Knipling-Bushland U.S. Livestock Insects Research Laboratory » Livestock Arthropod Pest Research Unit » Research » Publications at this Location » Publication #425096
Research Project: Management of Ticks of Veterinary Importance

Location: Livestock Arthropod Pest Research Unit

Title: Acetylcholinesterase 1 mRNA sequences from Riphicephalus annulatus strain Vega: RannAChE1-ATG1-5, RannAChE1-ATG2-1, RannAChE1-ATG3-10

Author
item Temeyer, Kevin
item Schlechte, Kristie

Submitted to: National Center for Biotechnology Information (NCBI)
Publication Type: Database / Dataset
Publication Acceptance Date: 3/6/2025
Publication Date: 4/2/2025
Citation: Temeyer, K.B., Schlechte, K.G. 2025. Acetylcholinesterase 1 mRNA sequences from Riphicephalus annulatus strain Vega: RannAChE1-ATG1-5, RannAChE1-ATG2-1, RannAChE1-ATG3-10. National Center for Biotechnology Information (NCBI). PV236116, PV236117, and PV236118.

Interpretive Summary: The cattle fever ticks Rhipicephalus microplus and Rhipicephalus annulatus transmit pathogens responsible for the serious cattle diseases bovine babesiosis and anaplasmosis. Although these ticks were eradicated from the United States, they and the pathogens they transmit still are endemic in Mexico and other countries, and remain a serious risk to the U.S. Cattle industry. Imported cattle are inspected and treated with acaricide to keep these ticks and pathogens from re-entry into the United States, and outbreak infestations within the united States are eradicated under the Cattle Fever Tick Eradication Program administered through the Veterinary Services Division of the Animal and Plant Inspection Service of the U.S. Department of Agriculture in cooperation with Animal Health Agencies of various states. The acaricide of first choice for treatment of imported cattle and eradication of outbreak infestations is the organophosphate, coumaphos, which kills ticks by inactivating acetylcholinesterase, an enzyme vital to function of the tick central nervous system. New research reports discovery of three different forms of the acetylcholinesterase 1 of Rhipicephalus annulatus, a species of cattle fever tick, which will enable further research to elucidate potential functional differences that will increase understanding of tick physiology and genetics potentially helping with the development of improved tick control technologies.

Technical Abstract: Three mRNA sequences encoding acetylcholiesterase 1 of the cattle fever tick Rhipicephalus annulatus strain Vega differing at their 5'-ends and encoding different probable transcriptional start sites were submitted to the GenBank database of the National Center for Biotechnology Information at https://www.ncbi.nlm.nih.gov/. GenBank accession numbers for the submissions were assigned as follows: Bankit2932997 RannAChE1-ATG1-5 accession # PV236116, Bankit2932997 RannAChE1-ATG2-1 accession # PV236117, and Bankit2932997 RannAChE1-ATG3-10 accession # PV236118.