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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #57177
Title: ACUTE PHASE IMMUNE RESPONSES IN EXERCISE

Author
item CANNON JOSEPH G - PENN STATE
item BLUMBERG JEFFREY - TUFTS-HNRCA

Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 1/1/1994
Publication Date: N/A
Citation: N/A

Interpretive Summary: Not required.

Technical Abstract: Heavy exercise, especially of the eccentric type, initiates an acute phase response that contributes to the breakdown and clearance of overloaded tissue. Following the exercise, the mobilization and activation of neutrophils appear to contribute to increased myocellular enzyme efflux. The acute phase reactions are unified by a common set of cytokine mediators including IL-1=DF, IL-6, and TNF which in turn influence some of their target tissues via induction of eicosanoids like PGE2. Importantly, these events are all modulated by peroxide tone and antioxidant defense status. The ability to intervene in this process through nutritional means suggests new approaches to determining the fundamental role of the acute phase response in exercise. This information can then be exploited for use in physical training regimens and in the prevention and treatment of inflammatory diseases.