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Title: ANTI-CHOLECYSTOKININ IMMUNOGLOBULINS ARE ASSOCIATED WITH FEED INTAKE OF LACTATING SOWS.

Author
item NELSON, DANIEL - MICHIGAN STATE UNIV
item Pekas, Jerome
item GARCIA-SIRERA, J - MICHIGAN STATE UNIV
item ROZEBOOM, D - MICHIGAN STATE UNIV
item HOGBERG, M - MICHIGAN STATE UNIV

Submitted to: Journal of Animal Science
Publication Type: Abstract Only
Publication Acceptance Date: 6/29/1995
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: The objectives were to determine if active immunization against cholecystokinin (CCK) would elicit antisera titers greater than 1:100 and stimulate ADFI. At 63 d gestation 20 gilts were vaccinated with the desulfated C-terminal octapeptide of CCK conjugated to Keyhole limpet hemocyanin (KLH) and 4 control gilts with KLH alone. Three booster vaccinations were at 14-d intervals. Essential procedures were described previously. Blood was collected at each vaccination and on d 7, 14 and 21 of lactation. A colostrum sample was collected from each sow and litter size was standardized to 10 piglets. In gestation, gilts received 1.9 kg feed/d. During lactation gilts were allowed ad libitum access to feed and ADFI was recorded. Two treated sows were removed due to poor health. Specific binding of radioiodinated CCK was not demonstrable at 1:10 dilution of serum from control sows. Antisera titers reached values greater than 1:10 during lactation in 14 of the remaining 18 treated sows. Anti-CCK titers of colostrum were greater than of serum. Immunoglobulins in colostrum must be considered to quantitate the immune response. Relationships between ADFI titers were analyzed by linear and quadratic regressions. The ADFI to d 7 and to d 21 of lactation increased as the log titer of both colostrum and serum at d 7 of lactation increased. Quadratic regressions indicated that ADFI increased as titers of colostrum approached 1:1000. It is concluded that anti-CCK titers in colostrum and serum are associated with ADFI of lactating sows.