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Title: CLONING AND CHROMOSOMAL ASSIGNMENT OF THE BOVINE INTERLEUKIN-2 RECEPTOR ALPHA GENE

Author
item Yoo, Jak
item PONCE DE LEON, F - UNIV. MASS.
item STONE, ROGER
item Beattie, Craig

Submitted to: Mammalian Genome
Publication Type: Abstract Only
Publication Acceptance Date: 5/30/1995
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Interleukin 2 receptor (IL-2R) is composed of three polypeptide chains, alpha, beta, and gamma, and plays a key role in the proliferation of activated T lymphocytes. A partial bovine genomic IL-2R-alpha sequence that contains approximately 8 kb of 5'-flanking region, exon 1, and 2 kb of intron 1, was cloned and assigned to chromosome 13q13-q14 by fluorescence in situ hybridization (FISH). The promoter region of bovine IL-2R-alpha shows significant sequence similarity to its human and mouse counterparts, suggesting that regulation of IL-2R-alpha gene expression is conserved among these species. Physical assignment of IL-2R-alpha to bovine chromosome 13 also demonstrates syntenic conservation of this gene between human, mouse and cattle.