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ARS Home » Research » Publications at this Location » Publication #61097
Title: NATIVE FOOT-AND-MOUTH DISEASE VIRUS NON-STRUCTURAL PROTEIN 2C AS A SEROLOGICAL INDICATOR TO DIFFERENTIATE INFECTED FROM VACCINATED LIVESTOCK

Author
item LUBROTH, JUAN - FADDL, GREENPORT, NY
item BROWN, FRED - YALE UNIVERSITY

Submitted to: Research in Veterinary Science
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/20/1995
Publication Date: N/A
Citation: N/A

Interpretive Summary: One of the more important problems in controlling foot-and-mouth disease is the inability to differentiate vaccinated animals from those that have recovered from the disease. This is because animals recovering from foot-and-mouth disease infection are potential carriers of the virus and could spread the disease. This paper describes a laboratory method which allows these two groups of animals to be distinguished and provides the scientific knowledge for developing a test which could be used in the field.

Technical Abstract: Cattle and pigs which have been vaccinated against foot-and-mouth disease can be distinguished from those that have been infected by measuring the activity of their sera in precipitating radioactively labelled proteins induced in virus-infected cells. Whereas the sera from infected animals precipitate all the virus-induced proteins, sera from vaccinated animals do not precipitate those proteins which are retained on the membranes of the cells used for growing the virus and are thus not included in the material used for preparing vaccines.