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Title: PATHOGENESIS OF INFECTION INDUCED BY AN ADENOVIRUS ISOLATED FROM A GOAT.

Author
item Lehmkuhl, Howard
item Cutlip, Randall
item MEEHAN, JAMES - HAZLETON WI.,MADISON, WI
item DEBEY, BRAD - VET.DIAG.LAB.,TULARE,CA.

Submitted to: American Journal of Veterinary Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/7/1996
Publication Date: N/A
Citation: N/A

Interpretive Summary: Respiratory tract disease results in economic loss to the goat industry. Adenoviruses are known to produce respiratory and enteric disease. An adenovirus (strain NC90-7261) isolated from a goat was used to inoculate goat kids to see if it would produce disease. The kids developed mild to moderate clinical respiratory tract disease consisting of fever, increased respiratory rate, listlessness, and lack of appetite. Virus was recovered consistently from nasal secretions and sporadically from fecal samples. Lesions were confined to the lungs of inoculated kids. These findings indicate that the caprine adenovirus is capable of producing respiratory tract disease and lesions in the lungs of young kids.

Technical Abstract: An adenovirus (strain NC90-7261) isolated from the brain of a 3-year-old goat with encephalitis was evaluated for pathogenicity in colostrum deprived goat kids following intranasal and transtracheal inoculation. The kids developed mild to moderate clinical respiratory tract disease consisting of fever, hyperpnea, listlessness, and anorexia. Virus was recovered consistently from nasal secretions and sporadically from fecal samples. Grossly. there were multiple areas of atelectasis and hyperemia, primarily in the cranio-ventral portion of the lungs. Histologically, there was detachment and sloughing of foci of epithelial cells of the terminal bronchioles and alveoli. These changes were accompanied by hyperplasia of the type II epithelial cells in kids necropsied late in the disease. There was no obvious evidence of viral inclusions in any of the tissues. These findings indicate that the caprine adenovirus is capable of producing respiratory tract disease and lesions in the lungs of young kids.