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Submitted to: American Chemical Society Abstracts
Publication Type: Abstract Only Publication Acceptance Date: 5/1/1996 Publication Date: N/A Citation: N/A Interpretive Summary: Technical Abstract: Although the existence of lipoxygenase has been known for over 60 years, only recently has there been a concerted effort to study conditions required to improve yields and immobilize its activity. Maintaining a high O2 tension is necessary to obtain good yields of hydroperoxides; whereas, partial anaerobic conditions can lead to hydroperoxide decomposition. Fatty hydroperoxides obtained from lipoxygenase action can serve as precursors for further transformation by either enzymes or chemical reactions. Well over one hundred products from lipoxygenase-generated hydroperoxides of linoleic acid alone have been described. Examples will be given of the formation of fatty acids with epoxide, hydroxy, ketone, cyclic, and multiple funtional groups. The cleavage of fatty hydroperoxides into short chain aldehydes and alcohols will also be described. Many of the products have biological activity suggesting a significant physiological function for lipoxygenase. |
