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Submitted to: Trace Elements in Man and Animals (TEMA)
Publication Type: Abstract Only Publication Acceptance Date: 5/19/1996 Publication Date: N/A Citation: N/A Interpretive Summary: Technical Abstract: Over the past decade, there have been 12 experiments reported on experimental copper deprivation, and/or interactions of copper (Cu) with other nutrients in adult humans. Cu intakes of these studies were between 0.4-1.25 mg of Cu/d for periods of 36-165 d. These were alternated with or followed by intakes of 2.6 to 6.4 mg of Cu/d. Biochemical and physiological changes resulting from Cu deprivation were noted in many, but not all, subjects consuming less than 1.2 mg of Cu/d. These include changes in electrocardiograms in 4 of 24 men with intakes of 1.02 mg of Cu/d from a high fructose diet after 77 d, 1 of 7 men fed 0.8 mg of Cu for 105 d, 3 of 6 men fed 0.6 mg of Cu for 49 d, and 3 of 13 postmenopausal women fed 0.57 mg Cu for 105 d. Plasma Cu was lowered with low Cu intake in only 4 of the 12 studies; it seemed to be related more to weight loss or fructose intake in two of these studies and was not as sensitive to changed Cu status as Cu enzymes in blood cells. Erythrocyte superoxide dismutase (ESOD) and cytochrome c oxidase in platelets or mononucleated white cells seemed to be the most sensitive indicators to changes in Cu status. Recovery from Cu deprivation, as indicated by recovery of ESOD activity was documented when 3 to 6.4 mg of Cu/d was fed for 30 d or more, but not when 2.6 mg or less was fed for up to 42 d. These studies indicate that 1.25 mg of Cu/d is needed for maintenance and that 2.6 mg of Cu/d, or less, for periods of up to 42 d is not sufficient for recovery from Cu deprivation. |
