Author
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WESTER, TIMOTHY - BAYLOR COLL OF MEDICINE |
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Davis, Teresa |
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Heath, Julian |
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MCAVOY, SUSAN - BAYLOR COLL OF MEDICINE |
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SKOTTNER, A. - BAYLOR COLL OF MEDICINE |
Submitted to: International Insulin and IGF Symposium
Publication Type: Proceedings Publication Acceptance Date: 11/10/1995 Publication Date: N/A Citation: N/A Interpretive Summary: Technical Abstract: We studied the effect of orally administered IGF-I on small intestinal (SI) growth in formula-fed neonatal pigs. Unsuckled neonatal pigs received formula (F; n=8) or formula containing added recombinant human IGF-I (F+IGF;3.5 mg /kg-1/d-1; n=7) from birth to 4 d of age. Pigs were pair-fed 30ml/kg formula every 2 h on d 1 and then every 4 h on d 2-4. Blood samples swere collected at birth, prior to the first feeding, and daily during the d period. Mean (plus or minus pooled SD) SI weight, protein and DNA masses per kg body weight and villus height after 4 d were: F F+IGF % chg SD SI Weight (g/kg BW) 29a 38b +28 4 SI Protein (mg/kg BW) 3366a 4499b +34 579 SI DNA (mg/kg BW) 130a 199b +53 34 Jejunum villus height(micro-m) 472a 822b +74 151 Ileum villus height(micro-m) 702a 944b +34 190 The plasma IGF-I concentration did not differ between F and F+IGF pigs at any sampling time. Thus, any potential absorption of added oral IGF-I from the intestinal lumen into the blood was insufficient to affect the circulating IGF-I concentration. Our results demonstrate that oral administration of a pharmacological dose of IGF-I during the first four days after birth significantly increased SI growth in neonatal pigs. |