Author
 |
POND, WILSON - USDA/ARS/CNRC |
|
Mersmann, Harry |
|
Submitted to: Nutrition Research
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 6/1/1996 Publication Date: N/A Citation: N/A Interpretive Summary: The pig is accepted as an appropriate animal model for research in cholesterol and lipoprotein metabolism. Genetically diverse populations differing in body fatness, plasma lipoproteins, and plasma total cholesterol concentration have been used to determine the impact of neonatal dietary cholesterol on development of the central nervous system (CNS) and on the atherogenic response to high fat-high cholesterol diets during adolescence. The observed preliminary relationships between neonatal dietary cholesterol and development in genetically diverse populations suggest the need for research to address questions for human infant nutrition: is neonatal cholesterol deprivation associated with long-term atherogenesis?; is it associated with compromised CNS development? Technical Abstract: Lipid metabolism and cholesterol homeostasis in swine are reviewed in relation to the use of the pig as a model for studying neonatal cholesterol nutrition. Several genetically unique pig populations used in cardiovascular and obesity research are described. Recent work with two specific genetically selected populations (obese and lean and high and low plasma cholesterol) is summarized. The results illustrate that dietary cholesterol during the neonatal period modulates central nervous system development and atherogenesis in some genetically distinct populations of swine. Implications for the role of dietary cholesterol in human infant nutrition are discussed. |
