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Title: AN ATYPICAL T-CELL LYMPHOSARCOMA IN A CALF WITH BOVINE IMMUNODEFICIENCY- LIKE VIRUS INFECTION

Author
item ROVID, A - IOWA STATE UNIV.,AMES,IA
item CARPENTER, S - IOWA STATE UNIV.,AMES,IA
item MILLER, L - IOWA STATE UNIV., AMES,IA
item FLAMING, K - IOWA STATE UNIV.,AMES,IA
item LONG, M - IOWA STATE UNIV.,AMES,IA
item Van Der Maaten, Martin
item FRANK, D - IOWA STATE UNIV.,AMES,IA
item ROTH, J - IOWA STATE UNIV.,AMES,IA

Submitted to: Veterinary Pathology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/1/1996
Publication Date: N/A
Citation: N/A

Interpretive Summary: An abnormal T-cell lymphoid neoplasm in a calf experimentally infected with bovine lentivirus is described. There is no evidence that the inoculation with bovine lentivirus caused an immunosuppression that allowed the tumor to develop. It is suggested, but not proven, that the pro- liferation of lymphoid cells associated with the bovine lentivirus infection may have contributed to the development of the tumors. This information would be of primary interest to veterinary pathologists and veterinarians involved in the diagnosis of these conditions in farm herds but, because of the relative rarity of tumors of this type, would have little economic impact on producers.

Technical Abstract: An 11-month-old Holstein calf experimentally infected with bovine immunodeficiency-like virus (BIV) developed T-cell lymphosarcoma 5 months postinoculation, concurrent with progressive monocytosis. Tumors were found in the thymus, multiple lymph nodes, and brain. Tumor cells were CD2+, CD4, CD8 T cells. Infectious BIV could be recovered from splenic tissue and blood mononuclear cells. Bovine leukemia virus was not present. Because this calf was part of an ongoing experiment on the pathogenesis of BIV infection, immune function data were also available both before and after lymphosarcoma developed. Neutrophil and monocyte function were normal, but lymphocyte blastogenesis was enhanced before the development of lymphosarcoma. Follicular hyperplasia in lymphoid tissues was also seen. This case raises the possibility that BIV infection may cause or be associated with some cases of atypical T-cell lymphosarcoma, without evidence of immune suppression at the time of tumor onset.