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Title: MONILIFORMIN BUT NOT FUMONISIN B1 INDUCED CARDIOMEGALY AND ELEVATED SERUM LACTATE IN BROILERS

Author
item WU, WEIDONG - UNIV WISCONSIN, MADISON
item Vesonder, Ronald

Submitted to: Southern Poultry Science Society Meeting Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: 1/21/1997
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: To find out which of the two mycotoxins, moniliformin (MN) and fumonisin B1 (FN) was capable of inducing cardiomegaly and elevated serum lactate, corn culture materials fermented with different Fusarium isolates M-1325 (producing FN but not MN), M-1214 (producing MN but not FN), and M-7176 (producing both MN and FN, plus an anti- thiamine factor) were fed to young broiler chicks for a period of time ranging from 6 to 14 days in several feeding trials. Only the culture materials containing MN induced high mortality (100% depending on dose), cardiomegaly (as measured by both heart mass and heart mass relative to body weight) with a concurrent elevation of serum lactate, and occasional ascites. Culture material containing only FN induced hepatomegaly and had no effects on heart mass and serum lactate. When purified MN was fed to broilers for 6 days, 30 ppm were required to cause cardiomegaly and elevation of serum lactate. When MN in culture material containing the anti-thiamine factor was fed to broilers, 15 ppm were required to cause cardiomegaly. It is concluded that MN is capable of causing cardiomegaly and elevation of serum lactate. The possible implication of moniliformin as both a predisposing factor and a causative factor for several poultry metabolic disorders, such as sudden death syndrome, round heart, and ascites, will be discussed.