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Title: IS LACTIC ACIDOSIS RESPONSIBLE FOR THE ELECTROCARDIOGRAPHIC CHANGES INDUCED BY INTRAVENOUS INJECTION OF MONILIFORMIN IN BROILERS?

Author
item NAGARAJ, R - UNIV OF WI, MADISON
item WU, W - UNIV OF WI, MADISON
item WILL, J - UNIV OF WI, MADISON
item VALDIVIA, H - UNIV OF WI, MADISON
item Vesonder, Ronald

Submitted to: Poultry Science Association Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 8/3/1997
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Measurements of electrocardiography (ECG), blood pH and plasma lactate and glucose were used to test the hypothesis that the acute cardiotoxic effects of moniliformin (MF) was due to lactic acidosis in broiler chickens. From a group of 5-week-old broiler chickens, one chick was chosen randomly at a time and anesthetized by intramuscular injection of pentobarbital sodium (40 mg/kg body weight). When the bird did not respond to pinch reflex, it was placed on dorsal recumbency and connected to a 3-lead electrocardiographic recorder. A catheter was placed in the wing vein. After measuring the basal ECG, the bird was injected with MF (1 mg/kg body weight, total of 5 birds) or saline equivalent (3 birds) and the lead II recordings were measured for the next 20 minutes. Venous blood was drawn at 3 time points (prior to, and 10 and 20 minutes after injection of MF or saline) and the blood pH, plasma lactate and glucose were measured. MF caused significant bradycardia (P < 0.01) within 10 minutes of injection. The MF- injected birds also showed a significant drop (P < 0.05) in blood pH within 20 minutes and elevation (P < 0.01) in plasma lactate levels within 10 minutes of injection. These results indicate that lactic acidosis is responsible for the acute cardiotoxic effects of MF in broiler chickens.