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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #84152
Title: VIRULENCE OF BOVINE VIRAL DIARRHEA VIRUS TYPE 2 IN BEEF CALVES

Author
item DEAN, H - SCHERING-PLOUGH ANIM HLTH
item LEYH, R - SCHERING-PLOUGH ANIM HLTH
item GOODYEAR, M - SCHERING-PLOUGH ANIM HLTH
item SOCKETT, D - WISCONSIN ANIM HLTH LAB
item Bolin, Steven - Steve
item CARTER, D - VETERINARY RESOURCES, INC
item EGAN, M - SCHERING-PLOUGH ANIM HLTH
item WARTHEN, M - SCHERING-PLOUGH ANIM HLTH

Submitted to: Research Workers in Animal Diseases Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 11/11/1997
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: The ability of a virulent field isolate of bovine viral diarrhea virus type 2 (BVDV2) to produce clinical signs and hemotologic changes in beef calves was investigated. The isolate, identified as BVDV2(WAHL-95), was obtained from a Wisconsin dairy herd undergoing a severe outbreak of BVDV2. Three doses of challenge virus were used in an attempt to determine a dose that would be sufficient to cause reproducible disease. BVDV2(WAHL-95) caused severe disease and mortalities at dose levels as low as 3.6 log10FAID50/calf. The virus caused severe thrombocytopenia and leukopenia in antibody positive and negative calves. Virus shedding and viremia occurred at all dose levels. Some calves failed to seroconvert following challenge. Clinical signs included respiratory distress/nasal secretions, diarrhea, oral ulcers, and mortality in all dose levels tested. These results demonstrate the susceptibility of beef as well as dairy breeds to contemporary virulent field isolates of BVDV2.