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ARS Home » Plains Area » Grand Forks, North Dakota » Grand Forks Human Nutrition Research Center » Healthy Body Weight Research » Research » Publications at this Location » Publication #87458
Title: IRON STATUS AND OXIDATIVE STRESS IN RATS AS AFFECTED BY INTERACTIONS AMONG DIETARY IRON, ZINC AND COPPER

Author
item Roughead, Zamzam
item Hunt, Janet

Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 4/17/1999
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: A surface response design was used to study the interactions among dietary Fe, Cu, and Zn affecting Fe status and oxidative stress. Weanling female Sprague-Dawley rats were fed modified AIN-93G diets varying in Fe and Zn (7, 15, 46, 136, or 300, ug/g diet), and Cu (0.5,1, 3, 9, 20, ug/g diet) for 6 weeks. Semi-partial coefficient correlations (R**2p) obtained by stepwise regression analysis are reported if p<0.01. Liver nonheme Fe was directly affected by dietary Fe (R**2p=0.63) with slight attenuation by interactions between Cu and Zn, and Zn and Fe. Variation in serum ferritin was mainly related to dietary Fe (R**2p=0.31) with a small contribution from an interaction between Cu and Zn. Serum Zn varied with dietary Zn (R**2p=0.47) with a slight negative influence from interaction of Cu and Fe. Serum ceruloplasmin (CP) activity (R**2=0.76) and serum Cu (R**2=0.77) were principally affected by dietary Cu with antagonistic effects from high dietary Zn and Fe, especially at low dietary Cu (