INHIBITORY EFFECTS OF TABEBUI AVELLANEDAE EXTRACT ON FUMONISIN B1 INDUCED SKIN CARCINOGENESIS

Authors: UEDA, SHINICHI - KYOTO UNIV, KYOTO, JAPAN; TOKUDA, HARUKUNI - KYOTO PREF UNIV, JAPAN; Vesonder, Ronald; MUKAINAKA, TERUO - KYOTO PREF UNIV, JAPAN; NICHINO, HOYOKU - KYOTO PREF UNIV, JAPAN

Submitted to: American Society of Pharmacognosy
Publication Type: Abstract Only
Publication Acceptance Date: 7/24/1998
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: The bark of this plant has been used as a diuretic and astringent. Upon a survey of anticancer effect, aqueous extract of Tabebui avellanedae were found to show an inhibitory effect on Epstein-Barr virus (EBV) early antigen activation and on two-stage mouse skin carcinogenesis induced by TPA. Following screening for cancer chemopreventive effect, we tested aqueous extract for their effect on DMBA-fumonisin B1 two-stage mouse skin carcinogenesis. This effect suggested that aqueous extract could be valuable for anti-tumor promoter in chemical carcinogenesis.