PASSIVE CROSS-PROTECTION PRODUCED BY A MONOCLONAL ANTIBODY AGAINST A 39 KDA MEMBRANE-ASSOCIATED ANTIGEN OF PASTEURELLA MULTOCIDA (ORAL PRESENTATION FOR THE AVMA/AAAP ANNUAL MEETING, JULY 10-14, 1999)

Authors: Rimler, Richard - Rick

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 4/13/1999
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Previous studies showed that a purified 39 kDa protein from in vivo Pasteurella multocida induced active cross-protection in turkeys, but serums from these turkeys did not produce passive cross-protection. In this study, mice were immunized with a partially-purified 39 kDa protein for monoclonal antibody (MAb) production. A MAb was produced that reacted with a 39 kDa protein epitope in immunoblots of in vivo, but not in vitro P. multocida. Turkeys passively immunized with the MAb were protected against fowl cholera caused by homologous and heterologous serotypes of P. multocida. The MAb passively protected chickens, but not mice, against a heterologous serotype challenge.