Antifungal/Antimycotoxigenic Publications, 2006 to present:

Kim, J.H.*, Chan, K.L., Hart-Cooper, W.M., Palumbo, J.D., Orts, W.J. 2023. High-efficiency fungal pathogen intervention for seed protection: new utility of long-chain alkyl gallates as heat-sensitizing agents. Frontiers in Fungal Biology. 4. doi: 10.3389/ffunb.2023.1172893. [PDF reprint]

Kim, J.*, Tam, C.C., Chan, K.L., Mahoney, N., Cheng, L.W., Friedman, M., Land, K.M.* 2022. Antimicrobial efficacy of edible mushroom extracts: assessment of fungal resistance. Applied Sciences. 12(9). Article 4591. doi: 10.3390/app12094591 [PDF reprint]

Kim, J.*, Chan, K.L. 2022. Natural salicylaldehyde for fungal and pre- and post-emergent weed control. Applied Sciences. 12(8). Article 3749. doi: 10.3390/app12083749 [PDF reprint]

Kim, J., Tam, C.C., Chan, K.L., Mahoney, N., Cheng, L.W., Friedman, M., Land,K.M. 2021. Antifungal activity of Antrodia cinnamomea mushroom extracts: Efficacy and resistance. Proceedings of the 7th International Electronic Conference on Medicinal Chemistry, 1–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ECMC2021-11384.

Kim, J., Cheng, L.W., Land, K.M., Gruhlke, M.C. 2021. Editorial: redox-active molecules as antimicrobials: mechanisms and resistance. Frontiers in Microbiology. 12. Article 758750. doi: 10.3389/fmicb.2021.758750. [PDF reprint]

Kim, J.*, Tam, C.C., Chan, K.L., Cheng, L.W., Land, K.M., Friedman, M., Chang, P. 2021. Antifungal efficacy of redox-active natamycin against some foodborne fungi—comparison with Aspergillus fumigatus. Foods. 10(9):2073. doi: 10.3390/foods1009207 [PDF reprint]

Tam, C.C., Nguyen, K., Nguyen, D., Hamada, S., Kwon, O., Kuang, I., Gong, S., Escobar, S., Lui, M., Kim, J., Hou, T., Tam, J., Cheng, L., Kim, J., Land, K.M., Friedman, M. 2021. Antimicrobial properties of tomato leaves, stems, and fruit and their relationship to chemical composition. BMC Complementary Medicine and Therapies. 21. Article 229. doi: 10.1186/s12906-021-03391-2 [PDF reprint]

Friedman, M., Tam, C.C., Kim, J., Escobar, S., Gong, S., Liu, M., Yu Mao, X., Do, C., Kuang, I., Boateng, K., Ha, J., Tran, M., Alluri, S., Le, T., Leong, R., Cheng, L.W., Land, K.M. 2021. Anti-parasitic activity of cherry tomato peel powders. Foods. 10(2):230. doi: 10.3390/foods10020230 [PDF reprint]

Kim, J.*, Cheng, L.W., Chan, K.L., Tam, C.C., Mahoney, N.E., Friedman, M., Shilman, M.M., Land, K.M. 2020. Antifungal drug repurposing. Antibiotics. 9(11):812. doi: 10.3390/antibiotics9110812 [PDF reprint]

Kim, J.*, Chan, K.L., Tam, C.C., Cheng, L.W., Land, K.M. 2020. Crosstalk between the antioxidant and cell wall integrity systems in fungi by 2-hydroxy-4-methoxybenzaldehyde. Cogent Food & Agriculture. 6(1):1823593. doi: 10.1080/23311932.2020.1823593 [PDF reprint]

Friedman, M., Xu, A., Lee, R., Nguyen, D.N., Phan, T.A., Hamada, S.M., Panchel, R., Tam, C.C., Kim, J., Cheng, L.W., Land, K.M. 2020. The inhibitory activity of anthraquinones against pathogenic protozoa, bacteria, and fungi and the relationship to structure. Molecules. 25(13):3101. doi: 10.3390/molecules25133101 [PDF reprint]

Kim, J.*, Chan, K.L., Mahoney, N.E., Cheng, L.W., Tautges, N., Scow, K. 2020. Rapid elimination of foodborne and environmental fungal contaminants by benzo analogs. Journal of the Science of Food and Agriculture. 100(6):2800–2806. doi: 10.1002/jsfa.10288 [PDF reprint]

Kim, J.*, Chan, K.L., Cheng, L.W., Tell, L.A., Byrne, B.A., Clothier, K., Land, K.M. 2019. High efficiency drug repurposing design for new antifungal agents. Methods and Protocols. 2(2),31. doi: 10.3390/mps2020031 [PDF reprint]

Kim, J. H.*, Chan, K. L., Cheng, L. W. 2018. Octyl gallate as an intervention catalyst to augment antifungal efficacy of caspofungin. J. 1(1), 4. doi: 10.3390/j1010004 [PDF reprint]

Kim, J. H.*, Chan, K. L., Cheng, L. W. 2017. Cinnamic acid analogs as intervention catalysts for overcoming antifungal tolerance. Molecules. 22(10):1783. doi: 10.3390/molecules22101783 [PDF reprint]

Singh, A., Nisha, Bains, T., Hahn, H.J., Liu, N., Tam, C.C., Cheng, L.W., Kim, J.H., Debnath, A., Land, K.M., Kumar, V. 2017. Design, synthesis and preliminary antimicrobial evaluation of n-alkyl chain tethered c-5 functionalized bis-isatins. MedChemComm. 8(10):1982-1992. doi: 10.1039/c7md00434f PMCID: PMC5810968.

Buckley, H.L., Hart-Cooper, W.M., Kim, J.H., Faulkner, D.N., Cheng, L.W., Chan, K.L., Vulpe, C.D., Orts, W.J., Amrose, S.E., Mulvihill, M.J. 2017. Design and testing of safer, more effective preservatives for consumer products. ACS Sustainable Chemistry & Engineering. 5(5):4320-4331. doi: 10.1021/acssuschemeng.7b00374.

Kim, J. H.*, Hart-Cooper, W.M., Chan, K. L., Cheng, L. W., Orts, W. J., Johnson, K. 2016. Antifungal efficacy of octylgallate and 4-isopropyl-3-methylphenol for control of Aspergillus. Microbiology Discovery. 4:2. doi: 10.7243/2052-6180-4-2 [PDF reprint]

Kim, J. H.*, Chan, K. L., Mahoney, N. E. 2015. Augmenting the activity of monoterpenoid phenols against fungal pathogens using 2-hydroxy-4-methoxybenzaldehyde that target cell wall integrity. International Journal of Molecular Sciences. 16(11): 26850-26870. doi: 10.3390/ijms161125988 [PDF reprint]

Kim, J. H.*, Chan, K. L., McConnell, L. L. 2015. Augmenting the efficacy of fungal and mycotoxin control via chemosensitization. Outlooks on Pest Management. 26(4): 171-175. doi: 10.1564/v26_aug_08 [PDF reprint available]

Kim, J. H.*, Chan, K. L. 2014. Model fungal systems for investigating food plant mycotoxins. In: Cheung, P. editor. Handbook of Food Chemistry: Springer-Verlag Berlin Heidelberg. doi: 10.1007/978-3-642-41609-5_7-1

Kim, J. H.*, Chan, K. L. 2014. Augmenting the antifungal activity of an oxidizing agent with kojic acid: Control of Penicillium strains infecting crops. Molecules. 19(11):18448-18464. doi: 10.3390/molecules191118448

Kim, J. H.*, Mahoney, N., Chan, K. L., Campbell, B. C., Haff, R.P., Stanker, L.H. 2014. Use of benzo analogs to enhance antimycotic activity of kresoxim methyl for control of aflatoxigenic fungal pathogens. Front. Microbio. 5: 87. doi: 10.3389/fmicb.2014.00087.

Kim, J. H.*, Haff, R.P., Faria, N. C. G., Martins, M. de L., Chan, K. L., Campbell, B. C. 2013. Targeting the mitochondrial respiratory chain of Cryptococcus through antifungal chemosensitization: A model for control of non-fermentative pathogens. Molecules. 18(8): 8873-8894. doi: 10.3390/molecules18088873 [PDF reprint]

Kim, J. H.*, Campbell, B. C., Chan, K. L., Mahoney, N., Haff, R.P. 2013. Synergism of antifungal activity between mitochondrial respiration inhibitors and kojic acid. Molecules. 18(2): 1564-1581. doi: 10.3390/molecules18021564 [PDF reprint]

Kim, J. H.*, Chang, P.-K., Chan, K. L., Faria, N. C. G., Mahoney, N., Kim, Y. K., Martins, M. de L., Campbell, B. C. 2012. Enhancement of commercial antifungal agents by kojic acid. Int. J. Mol. Sci. 13(11):13867-13880. doi: 10.3390/ijms131113867 [PDF reprint]

Kim, J. H., Faria, N. C. G., Martins, M. de L., Chan, K. L., Campbell, B. C.* 2012. Enhancement of antimycotic activity of amphotericin B by targeting the oxidative stress response of Candida and Cryptococcus with natural dihydroxybenzaldehydes. Front. Microbio. 3: 261. doi: 10.3389/fmicb.2012.00261.

Campbell, B. C.*, Chan, K. L., Kim, J. H. 2012. Chemosensitization as a means to augment commercial antifungal agents. Front. Microbio. 3: 79. doi: 10.3389/fmicb.2012.00079.

Dzhavakhiya, V., Scherbakova, L., Semina, Y., Zhemchuzhina, N., Campbell, B. 2012. Chemosensitization of plant pathogenic fungi to agricultural fungicides. Front. Microbio. 3: 87. doi: 10.3389/fmicb.2012.00087.

Kim, J. H., Chan, K. L., Faria, N. C. G., Martins, M. de L., Campbell, B. C.* 2012. Targeting the oxidative stress response system of fungi with safe, redox-potent chemosensitizing agents. Front. Microbio. 3: 88. doi: 10.3389/fmicb.2012.00088.

Chang, P.-K., Scharfenstein, L. L., Luo, M., Mahoney, N., Molyneux, R. J., Yu, J., Brown, R. L., Campbell, B. C. 2011. Loss of msnA, a putative stress regulatory gene, in Aspergillus parasiticus and Aspergillus flavus increased production of conidia, aflatoxins and kojic acid. Toxins 3(1): 82-104. doi: 10.3390/toxins3010082 [PDF reprint]

Faria, N. C. G., Kim, J. H., Goncalves, L. a. P., Martins, M. de L., Chan, K. L., Campbell, B. C.* 2011. Enhanced activity of antifungal drugs using natural phenolics against yeast strains of Candida and Cryptococcus. Lett. Appl. Microbiol. 52(5): 506-513. doi: 10.1111/j.1472-765x.2011.03032.x [PDF reprint]

Kim, J. H. and Campbell, B. C.* 2011. Chemogenomic analysis of fungal stress-response systems using phytochemicals. In: Pirttilä, A. M. and Sorvari, S. (eds.). Prospects and Applications for Plant-Associated Microbes, A Laboratory Manual, Part B: Fungi. pp. 80-87. BioBien Innovations. Paimio, Finland. 328 pp.

Kim, J. H. and Campbell, B. C.* 2011. Chemosensitization of fungal pathogens to antimicrobial agents using phenolic compounds. In: Pirttilä, A. M. and Sorvari, S. (eds.). Prospects and Applications for Plant-Associated Microbes, A Laboratory Manual, Part B: Fungi. pp. 212-214. BioBien Innovations. Paimio, Finland. 328 pp.

Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., and Molyneux, R. J. 2011. Chemosensitization of aflatoxigenic fungi to antimycin A and strobilurin using salicylaldehyde, a volatile natural compound targeting cellular antioxidation system. Mycopathologia. 171(4): 291-298. doi: 10.1007/s11046-010-9356-8 [PDF reprint]

Kim, J. H., Mahoney, N., Chan, K. L., Campbell, B. C.*. 2011. Antifungal activity of redox-active benzaldehydes that target cellular antioxidation. Annals of Clinical Microbiology and Antimicrobials 10:23. doi: 10.1186/1476-0711-10-23 [PDF reprint]

Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J., and Xiao, C.-L. 2010. Use of chemosensitization to overcome fludioxonil-resistance in Penicillium expansum. Letters Appl. Microbiol. 51(2): 177-183. doi: 10.1111/j.1472-765x.2010.02875.x [PDF reprint]

Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J. and Balajee, A. 2010. Augmenting the activity of antifungal agents against aspergilli using structural analogues of benzoic acid as chemosensitizing agents. Fungal Biol. 114(10): 817-824. doi: 10.1016/j.funbio.2010.07.008 [PDF reprint]

Mahoney, N., Molyneux, R. J., Kim, J. H., Campbell, B. C., Waiss, A. C. and Hagerman, A. E. 2010. Aflatoxigenesis induced in Aspergillus flavus by oxidative stress and reduction by phenolic antioxidants from tree nuts. World Mycotoxin J. 3(1): 49-57. doi: 10.3920/WMJ2009.1185 [PDF reprint]

Yu, J., Nierman, W. C., Bennett, J. W., Campbell, B. C., Bhatnagar, D., Cleveland, T. E. and Payne, G. A. Genetics and Genomics of Aspergillus flavus. In: Rai, M. K. (ed). Progress in Mycology. pp. 51-73. Springer Verlag. ISBN: 978-90-481-3712-1.

Molyneux, R. J., Mahoney, N., Kim, J. H., and Campbell, B. C. Health aspects and antiaflatoxigenic activity of phytochemicals in tree nuts. In: Alasalvar, C. and Shahidi, F. (eds.). Tree Nuts: Composition, Phytochemicals, and Health Effects. pp. 95-107. CRC Press, Boca Raton, FL. [PDF reprint]

Campbell, B. C., Kim, J. H., Yu, J., Molyneux, R. J., Mahoney, N. Palumbo, J. D., Chan, K. L., Bhatnagar, D. Cleveland, T. E. and Nierman, W. C. Natural products as tools for chemogenomic analysis of mycotoxin biosynthesis and fungal stress-response systems. In: Siantar, D. P., Trucksess, M., Scott, P. M. and Herman, E. M. (eds.). Food Contaminants: Mycotoxins and Food Allergens. Proceedings of the 232nd National Meeting of the American Chemical Society, Symposium Series No. 1001. Chapter 1. ISBN13 978-0-8412-6954-5.

Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J. and May, G. S. 2008. Chemosensitization prevents tolerance of Aspergillus fumigatus to antimycotic drugs. Biochem. Biophys. Res. Comm. 372: 266-271. doi: 10.1016/j.bbrc.2008.05.030 [PDF reprint]

Kim, J. H., Mahoney, N., Chan, K. L,. Molyneux, R. J. , May, G. S. and Campbell, B. C.*2008. Chemosensitization of fungal pathogens to antimicrobial agents using benzo analogs. FEMS Microbiol. Lett. 281(1): 64-72. doi: 10.1111/j.1574-6968.2008.01072.x [PDF reprint]

Kim, J. H., Yu, J., Mahoney, N., Chan, K. L., Molyneux, R. J., Varga, J., Bhatnagar, D., Cleveland, T. E., Nierman, W. C. and Campbell, B. C.*2008. Elucidation of the functional genomics of antioxidant-based inhibition of aflatoxin biosynthesis. Int. J. Food Microbiol. 122: 49-60. doi: 10.1016/j.ijfoodmicro.2007.11.058 [PDF reprint]

Molyneux, R. J., Mahoney, N., Kim, J. H. and Campbell, B. C.2008. Bioassay-directed isolation and identification of anti-aflatoxigenic constituents of walnuts. In: Colegate, S. M. and Molyneux, R. J. (eds). Bioactive Natural Products: Detection, Isolation and Structural Identification. pp. 421-437. CRC Press, Boca Raton, FL.

Yu, J., Payne, G. A., Campbell, B. C., Guo, B. Z., Cleveland, T. E., Robens, J. F., Keller, N. P., Bennett, J. W. and Nierman, W. C. 2008. Mycotoxin production and prevention of aflatoxin contamination in food and feed. In: Osmani, S. and Goldman, G. (eds). The ASPERGILLI: Genomics, Medical Aspects, Biotechnology, and Research Methods. pp. 457-472. CRC Press, Boca Raton, FL.

Yu, J., Payne, G. A., Nierman, W. C., Machida, M., Bennett, J. W., Campbell, B. C., Robens, J. F., Bhatnagar, D., Dean, R. A. and Cleveland, T. E. 2008. Aspergillus flavus genomics as a tool for studying the mechanism of aflatoxin formation. Food Addit. Contamin. 25(9): 1152-1157. doi: 10.1080/02652030802213375 [PDF reprint]

Beck, J. J., Kim, J. H., Campbell, B. C.and Chou, S.-C. 2007. Fungicidal activities of dihydroferulic acid alkyl ester analogues. J. Nat. Prod. 70(5): 779-782. doi: 10.1021/np0606345

Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J. and May. G. S. 2007. Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress response. Lett. Appl. Microbiol. 45(2):134-141. doi: 10.1111/j.1472-765x.2007.02159.x [PDF reprint]

Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J. and May, G. S. 2007. Enhancement of fludioxonil fungicidal activity by disrupting cellular glutathione homeostasis with 2,5-dihydroxybenzoic acid. FEMS Microbiol. Lett. 270(2): 284-290. doi: 10.1111/j.1574-6968.2007.00682.x [PDF reprint]

Lee, S.-E., Park, B. S., Bayman, P., Baker, J. L., Choi, W. S. and Campbell, B. C. 2007. Suppression of ochratoxin biosynthesis by naturally occurring alkaloids. Food Addit. Contamin. 24(4): 391-397. doi: 10.1080/02652030601053147 [PDF reprint]

Molyneux, R. J., Mahoney, N., Kim, J. H. and Campbell, B. C.2007. Mycotoxins in edible tree nuts. Int. J. Food Microbiol. 119: 72-78. doi: 10.1016/j.ijfoodmicro.2007.07.028 [PDF reprint]

Molyneux, R. J., Mahoney, N., Kim, J. H. and Campbell, B. C.2007. Inhibition of aflatoxin biosynthesis in Aspergillus flavus by phenolic natural products. pp. 231-251 In: Natural Products: Essential Resources for Human Survival (Zhu, Y.-Z, Tan, B. K.-H., Bay, B.-H. and Liu, C.-H., eds.) World Scientific Publishing Co., Singapore.

Yu, J., Ronning, C. M., Wilkinson, J. R., Campbell, B. C., Payne, G. A., Bhatnagar, D., Cleveland, T. E. and Nierman, W. C. 2007. Gene profiling for studying the mechanism of aflatoxin biosynthesis in Aspergillus flavus and A. parasiticus. Food Addit. Contamin. 24(10): 1035-1042. doi: 10.1080/02652030701513800 [PDF reprint]

Kim, J. H., Mahoney, N., Chan, K. L., Molyneux. R. J. and Campbell, B. C.*. 2006. Controlling food-contaminating fungi by targeting their antioxidative stress-response system with natural phenolic compounds. Appl. Microbiol. Biotechnol. 70(6): 735-739. doi: 10.1007/s00253-005-0123-6" [PDF reprint]

Kim, J. H., Campbell, B. C.*, Yu, J., Mahoney, N., Chan, K. L., Molyneux, R. J., Bhatnagar, D. and Cleveland, T. E. 2006. High throughput genetic tool for examining effects of natural products in fungi. pp. 27-33. In: EBA 2005 Proc. 1st Intl. Conf. Plant Microbe Interactions: Endophytes and Biocontrol Agents. (Sovari, S. and Toldi, O., eds.). Saariselkä , Finland, 18-22 April 2005. Karhukopio OY, Turku, Finland. 176 pp.

Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L. and May, G. S. 2006. Targeting antioxidative signal transduction and stress response system: Control of pathogenic Aspergillus with phenolics that inhibit mitochondrial function. J. Appl. Microbiol. 101(1): 181-189. doi: 10.1111/j.1365-2672.2006.02882.x [PDF reprint]

Kim, J. H., Campbell, B. C.*, Molyneux, R. J., Mahoney, N., Chan, K. L., Yu, J., Wilkinson, J., Cary, J., Bhatnagar, D. and Cleveland., T. E. 2006. Gene targets for fungal and mycotoxin control. Mycotoxin Research 22(1): 3-8. doi: 10.1007/bf02954550 [PDF reprint]

Yu, J., Cleveland, T. E., Wilkinson, J. R., Campbell, B. C., Kim, J. H., Kim, H. S., Bhatnagar, D., Payne, G. A. and Nierman, W. C. 2006. Aspergillus flavus expressed sequence tags and microarray as tools in understanding aflatoxin biosynthesis. Mycotoxin Research 22(1): 16-21. doi: 10.1007/bf02954552 [PDF reprint]