Kable Lab : USDA ARS

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Kable Lab

KABLE LAB

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- Mary Kable, Ph.D.
  
  Research Scientist
  
  Adjunct Assistant Professor, UC Davis Department of Nutrition
  
  Office: (530) 752-1607
  
  Email address: mary.kable@usda.gov
  
  Google Scholar page
  
  Research Interests
  
  The Kable laboratory is interested in mechanisms governing how diet impacts the bacterial composition of the human gut and how these diet-bacterial interactions can influence human health. In particular, we are interested in how dietary fiber can affect the composition of the gut microbiota in such a way as to increase or decrease colonization resistance and susceptibility to food borne pathogens.
  
  Kable Lab Themes
  
  The Kable Lab research is currently focused on (1) characterization of the gut microbiota in a healthy human cohort and potential interactions between this composition and the long term dietary habits of healthy individuals, (2) optimization of methods for medium through-put culture of diverse gut microbiota, (3) in vitro fermentation of complete gut microbiota and individual bacteria from healthy human subjects with various food components, especially dietary fiber.

- ARS Employees
  
  David Storms, Support Scientist
  
  Laurynne Coates, USDA Postdoctoral Researcher
  
  Trainees
  
  Ste Traxler, Graduate Student Researcher
  
  Sarah Spearman, UC Davis Junior Specialist
  
  Alyce Faso, UC Davis Undergraduate Volunteer

- (Clicking on the reprint icon will take you to the publication reprint.)
- The role of the gut microbiome in predicting response to diet and the development of precision nutrition models. Part II: Results-()
  Riley, H.L., Kable, M.E., Marco, M.L., Keim, N.L. 2019. The role of the gut microbiome in predicting response to diet and the development of precision nutrition models. Part II: Results. Advances in Nutrition. https://doi.org/10.1093/advances/nmz049.
- Fecal metatranscriptomics of macaques with idiopathic chronic diarrhea reveals altered mucin degradation and fucose utilization-(Peer Reviewed Journal)
  Westreich, S.T., Ardeshir, A., Alkan, Z., Kable, M.E., Korf, I., Lemay, D.G. 2019. Fecal metatranscriptomics of macaques with idiopathic chronic diarrhea reveals altered mucin degradation and fucose utilization. BMC Microbiome. 7:41. https://doi.org/10.1186/s40168-019-0664-z.
- The role of the gut microbiome in predicting response to diet and the development of precision nutrition models. Part I: Overview of Current Methods-()
  Hughes, R.L., Marco, M., Hughes, J.P., Keim, N.L., Kable, M.E. 2019. The role of the gut microbiome in predicting response to diet and the development of precision nutrition models. Part I: Overview of Current Methods. Advances in Nutrition. https://doi.org/10.1093/advances/nmz022.
- Host determinants of expression of the helicobacter pylori BabA adhesin-(Peer Reviewed Journal)
  Kable, M.E., Hansen, L.M., Styer, C.M., Gideonsson, P., Deck, S.L., Shevtsova, A., Rakhimova, O., Eaton, K.A., Martin, M.E., Boren, T., Solnick, J.V. 2017. Host determinants of expression of the helicobacter pylori BabA adhesin. Scientific Reports. 7:46499.
- The effects of moderate whole grain consumption on fasting glucose and lipids, gastrointestinal symptoms, and microbiota-(Peer Reviewed Journal)
  Cooper, D.N., Kable, M.E., Marco, M.L., De Leon, A., Rust, B.M., Baker, J.E., Horn, W.F., Burnett, D., Keim, N.L. 2017. The effects of moderate whole grain consumption on fasting glucose and lipids, gastrointestinal symptoms, and microbiota. Nutrients. 9(2):173. doi: 10.3390/nu9020173.
- The metatranscriptome of the rhesus macaque: investigating potential causes of idiopathic chronic diarrhea-(Abstract Only)
  Westreich, S.T., Ardeshir, A., Kable, M.E., Korf, I., Lemay, D.G. 2016. The metatranscriptome of the rhesus macaque: investigating potential causes of idiopathic chronic diarrhea. Experimental Biology. 31/650.

Prominent Projects

Impact of Diet on Intestinal Microbiota, Gut Health and Immune Function

	In-House Appropriated (D)
	Accession Number:432895

Assessment of Antimicrobial Resistance Genes in Human Fecal Samples

	Non-Assistance Cooperative Agreement (S)
	Accession Number:436885

Mothers, Infants and Lactation Quality-Extra Analyses (MILQ II) Project II

	Trust Fund Cooperative Agreement (T)
	Accession Number:437095

The Role of Honey and Small Intestine Microbes in Digestive Health

	Trust Fund Cooperative Agreement (T)
	Accession Number:435767

Association of Dairy Intake With Protection Against Gastrointestinal Inflammation

	Trust Fund Cooperative Agreement (T)
	Accession Number:436064

- Methods and Technique
  
  The Kable Lab focuses on methods for the analysis of human gut microbes. For growth and fermentation experiments we use a:
  
  2.7’ x 6.5’ Coy vinyl anaerobic chamber with space for two people to work, equipped with
  
  • airlock,
  
  •oxygen/hydrogen monitor,
  
  • hydrogen sulfide removal system,
  
  • incubator
  
  • and SPECTROstar Nano full UV/Vis spectrum absorbance microplate reader with cuvette port
  
  Endpoints analyzed in the Kable Lab:
  
  • 16S rRNA sequence based assessment of human gut microbial communities
  
  • Cultured bacterial isolates from human gut samples
  
  • Bacterial growth curves, antibiotic susceptibility, etc.
  
  • Trans-epithelial resistance of colonic epithelial cells after exposure to microbial fermentation products

U.S. DEPARTMENT OF AGRICULTURE

Diet, Microbiome and Immunity Research: Davis, CA

Research Scientist

Research Team

Selected Publications

Prominent Projects

Methods, Technique and Software