Cristina Cunha
Animal Disease Research
Veterinary Medical Officer
Phone: (509) 335-6072
Fax: (509) 335-8328
(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
Publications
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Ovine herpesvirus 2 glycoprotein B complementation restores infectivity of a bovine herpesvirus 4 gB-null mutant
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More, D.D., Baker, K.N., Shringi, S., Bastos, R.G., O'Toole, D., Donofrio, G., Cunha, C.W. 2024. Ovine herpesvirus 2 glycoprotein B complementation restores infectivity of a bovine herpesvirus 4 gB-null mutant. Pathogens. 13(3). Article 219. https://doi.org/10.3390/pathogens13030219.
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Coding complete genome of a strain of ovine herpesvirus-2 associated with a clinical case of malignant catarrhal fever in a domestic lamb
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Herndon, D.R., Herndon, M.K., Cunha, C.W. 2024. Coding complete genome of a strain of ovine herpesvirus-2 associated with a clinical case of malignant catarrhal fever in a domestic lamb. Microbiology Resource Announcements. 13. Article e01107-23. https://doi.org/10.1128/mra.01107-23.
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Herpes simplex virus 1 glycoprotein B from a hyperfusogenic
virus mediates enhanced cell–cell fusion.
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Gianopulos, K.A., Makio, A.O., Pritchard, S.M., Cunha, C.W., Hull, M.A., Nicola, A.V. 2024. Herpes simplex virus 1 glycoprotein B from a hyperfusogenic virus mediates enhanced cell–cell fusion.. Viruses. 16(2). Article 251. https://doi.org/10.3390/v16020251.
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Reemerging/notifiable diseases to watch
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Wainwright, S.H., Cunha, C.W., Webb, B., McGregor, B.L., Drolet, B.S., Welch, J.B. 2024. Reemerging/notifiable diseases to watch. Veterinary Clinics of North America. 40(2):317-335. https://doi.org/10.1016/j.cvfa.2024.01.007.
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Immunohistochemical identification of a malignant catarrhal fever virus in cattle with renal diseases from Paraná state, Southern Brazil: A retrospective epidemiological study
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Xavier, A.A., Queiroz, G.R., Lisbôa, J.A., Cunha, C.W., Headley, S.A. 2023. Immunohistochemical identification of a malignant catarrhal fever virus in cattle with renal diseases from Paraná state, Southern Brazil: A retrospective epidemiological study. Tropical Animal Health and Production. 55. Article 344. https://doi.org/10.1007/s11250-023-03740-y.
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A serological screening for potential viral pathogens among semi-domesticated Eurasian tundra reindeer (Rangifer tarandus tarandus) in Finland
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Tryland, M., Cunha, C.W., Fuchs, B., Breines, E., Li, H., Jokelainen, P., Laaksonen, S. 2023. A serological screening for potential viral pathogens among semi-domesticated Eurasian tundra reindeer (Rangifer tarandus tarandus) in Finland. Acta Veterinaria Scandinavica. 65. Article 8. https://doi.org/10.1186/s13028-023-00671-4.
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A screening for virus infections among wild Eurasian tundra reindeer (Rangifer tarandus tarandus) in Iceland, 2017-2019
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Tryland, M., Romano, J., Nymo, I., Mørk, T., Þórarinsdóttir, R., Breines, E., Li, H., Cunha, C.W., Thórisson, S. 2023. A screening for virus infections among wild Eurasian tundra reindeer (Rangifer tarandus tarandus) in Iceland, 2017-2019. Viruses. 15(2). Article 317. https://doi.org/10.3390/v15020317.
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A vaccine targeting ovine herpesvirus 2 glycoprotein B protects against sheep-associated malignant catarrhal fever
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Cunha, C.W., Baker, K.N., O'Toole, D., Cole, E., Shringi, S., Dewals, B.G., Vanderplasschen, A., Li, H. 2022. A vaccine targeting ovine herpesvirus 2 glycoprotein B protects against sheep-associated malignant catarrhal fever. Vaccines. 10(12). Article 2156. https://doi.org/10.3390/vaccines10122156.
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Ovine gammaherpesvirus-2 infection associated with chronic interstitial pneumonia in a sheep
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Headley, S.A., Dall Agnol, A.M., Navolar, F.M., Frucchi, A.P., de Matos, A.M., Pereira, P.F., Xavier, A.A., Santos, V.H., Silva, L.E., Depes, V.C., Alfieri, A.F., Cunha, C.W., Alfieri, A.A. 2021. Ovine gammaherpesvirus-2 infection associated with chronic interstitial pneumonia in a sheep. Microbial Pathogenesis. 161. Article 105220. https://doi.org/10.1016/j.micpath.2021.105220.
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A screening for virus infections in eight herds of semi-domesticated Eurasian tundra reindeer (Rangifer tarandus tarandus) in Norway, 2013–2018
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Tryland, M., Sánchez Romano, J., Nymo, I.H., Breines, E.M., Ancin Murguzur, F.J., Kjenstad, O.C., Li, H., Cunha, C.W. 2021. A screening for virus infections in eight herds of semi-domesticated Eurasian tundra reindeer (Rangifer tarandus tarandus) in Norway, 2013–2018. Frontiers in Veterinary Science. 8. Article 707787. https://doi.org/10.3389/fvets.2021.707787.
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The participation of a malignant catarrhal fever virus and Mycoplasma bovis in the development of single and mixed infections in beef and dairy cattle with bovine respiratory disease
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Oliveira, T.E., Scuisato, G.S., Pelaquim, I.F., Cunha, C.W., Cunha, L.S., Flores, E.F., Pretto-Giordano, L.G., Lisboa, J.A., Alfieri, A.A., Saut, J.P., Cunha, P.H., Headley, S.A. 2021. The participation of a malignant catarrhal fever virus and Mycoplasma bovis in the development of single and mixed infections in beef and dairy cattle with bovine respiratory disease. Frontiers in Veterinary Science. 8. Article 691448. https://doi.org/10.3389/fvets.2021.691448.
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OvHV-2 glycoprotein B delivered by a recombinant BoHV-4 is immunogenic and induces partial protection against sheep-associated malignant catarrhal fever in a rabbit model
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Shringi, S., O'Toole, D., Cole, E., Baker, K.N., White, S.N., Donofrio, G., Li, H., Cunha, C.W. 2021. OvHV-2 glycoprotein B delivered by a recombinant BoHV-4 is immunogenic and induces partial protection against sheep-associated malignant catarrhal fever in a rabbit model. Vaccines. 9(2). Article 90. https://doi.org/10.3390/vaccines9020090.
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Diphtheric aspergillosis tracheitis with gastrointestinal dissemination secondary to viral infections in a dairy calf
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Headley, S.A., Muller, M.C., de Oliveira, T.E.S., Barros Gil Duarte, C.A., Valente Pereira, P.F., Vieira, M.V., Cunha, C.W., Flores, E.F., Lisboa, J.A.N., Pretto-Giordano, L.G. 2020. Diphtheric aspergillosis tracheitis with gastrointestinal dissemination secondary to viral infections in a dairy calf. Microbial Pathogenesis. 149. Article 104497. https://doi.org/10.1016/j.micpath.2020.104497.
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A review of the epidemiological, clinical, and pathological aspects of malignant catarrhal fever in Brazil
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Headley, S.A., de Oliveira, T.E.S., Cunha, C.W. 2020. A review of the epidemiological, clinical, and pathological aspects of malignant catarrhal fever in Brazil. Brazilian Journal of Microbiology. 51:1405-1432. https://doi.org/10.1007/s42770-020-00273-6.
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Ibex-associated malignant catarrhal fever in duikers (Cephalophus spp)
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Carvallo, F.R., Uzal, F.A., Moore, J.D., Jackson, K., Nyaoke, A.C., Naples, L., Davis-Powell, J., Stadler, C.K., Boren, B.A., Cunha, C.W., Li, H., Pesavento, P.A. 2020. Ibex-associated malignant catarrhal fever in duikers (Cephalophus spp). Veterinary Pathology. 57(4):577-581. https://doi.org/10.1177/0300985820918313.
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Immunohistochemical detection of intralesional antigens of Ovine gammaherpesvirus-2 in cattle with sheep-associated malignant catarrhal fever
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Headley, S.A., Oliveria, T.E.S., Li, H., Lisbôa, J.A.N., Queiroz, G.R., Fritzen, J.T.T., Flores, E.F., Alfieri, A.A., Cunha, C.W. 2019. Immunohistochemical detection of intralesional antigens of Ovine gammaherpesvirus-2 in cattle with sheep-associated malignant catarrhal fever. Journal of Comparative Pathology. 174:86-98. https://doi.org/10.1016/j.jcpa.2019.11.002.
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Domestic sheep and bighorn sheep carry distinct gammaherpesviruses belonging to the genus Macavirus
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Cunha, C.W., Slater, O.M., Macbeth, B., Duignan, P.J., Warren, A., Highland, M.A., Li, H. 2019. Domestic sheep and bighorn sheep carry distinct gammaherpesviruses belonging to the genus Macavirus. Virus Research. 272. https://doi.org/10.1016/j.virusres.2019.197729.
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A rabbit model for sheep-associated malignant catarrhal fever research: from virus infection to pathogenesis studies and vaccine development
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Cunha, C.W., O'Toole, D., Taus, N.S., Shringi, S., Knowles, D.P., Li, H. 2019. A rabbit model for sheep-associated malignant catarrhal fever research: from virus infection to pathogenesis studies and vaccine development. Current Clinical Microbiology Reports. 6:148-155. https://doi.org/10.1007/s40588-019-00126-3.
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In situ hybridization for localization of ovine herpesvirus 2, the agent of sheep-associated malignant catarrhal fever, in formalin-fixed tissues
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Pesavento, P., Cunha, C.W., Li, H., Jackson, K., O'Toole, D. 2018. In situ hybridization for localization of ovine herpesvirus 2, the agent of sheep-associated malignant catarrhal fever, in formalin-fixed tissues. Veterinary Pathology. 56(1):78-86. https://doi.org/10.1177/0300985818798085.
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Systemic necrotizing vasculitis in sheep is associated with ovine herpesvirus 2
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Pesavento, P., Dange, R., Estrada, M., Dasjerdi, A., Pérez, V., Laroca, A., Silván, J., Diab, S., Jackson, K., Phillips, I., Li, H., Cunha, C.W., Wessels, M. 2018. Systemic necrotizing vasculitis in sheep is associated with ovine herpesvirus 2. Veterinary Pathology. 56:(1)87-92. https://doi.org/10.1177/0300985818795166.
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Evaluation of glycoprotein Ov8 as a potential antigen for an OvHV-2-specific diagnostic assay
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Alhajri, S.M., Cunha, C.W., Knowles, D.P., Li, H., Taus, N.S. 2018. Evaluation of glycoprotein Ov8 as a potential antigen for an OvHV-2-specific diagnostic assay. PLoS One. 13(7):30200130. https://doi.org/10.1371/journal.pone.0200130.
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Moose (alces alces) mortality associated with caprine herpesvirus 2 (CPHV-2) in a zoological collection
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Seeley, K., Junge, R., Jennings, R., Cunha, C.W., Li, H. 2018. Moose (alces alces) mortality associated with caprine herpesvirus 2 (CPHV-2) in a zoological collection. Journal of Zoo and Wildlife Medicine. 49(3):774-778. https://doi.org/10.1638/2016-0207.1.
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High copy number of ovine gammaherpesvirus 2 DNA associated with malignant catarrhal fever-like syndrome in a lamb
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Phillips, I.L., Cunha, C.W., Galbraith, D., Highland, M.A., Bildfell, R.J., Li, H. 2018. High copy number of ovine gammaherpesvirus 2 DNA associated with malignant catarrhal fever-like syndrome in a lamb. Journal of Veterinary Diagnostic Investigation. https://doi.org/10.1177/1040638718766976.
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Ovine herpesvirus 2 glycoproteins B, H, and L are sufficient for, and viral glycoprotein Ov8 can enhance, cell-cell membrane fusion
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Alhajri, S.M., Cunha, C.W., Nicola, A.V., Aguilar, H.C., Li, H., Taus, N.S. 2017. Ovine herpesvirus 2 glycoproteins B, H, and L are sufficient for, and viral glycoprotein Ov8 can enhance, cell-cell membrane fusion. Journal of Virology. doi: 10.1128/JVI.02454-16.
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Alcelaphine gammaherpesvirus 1-induced malignant catarrhal fever in a Watusi (bos taurus africanus) steer in a North American game park
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Bildfell, R.J., Li, H., Alcantar, B., Cunha, C.W., Bradway, D.S., Thomas, K.S. 2017. Alcelaphine gammaherpesvirus 1-induced malignant catarrhal fever in a Watusi (bos taurus africanus) steer in a North American game park. Journal of Veterinary Diagnostic Investigation. https://doi.org/10.1177?1040638717708392.
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Sheep-associated malignant catarrhal fever-like skin disease in a free-ranging bighorn sheep (Ovis canadensis), Alberta, Canada
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Slater, O.M., Kennedy-Peters, J., Lejeune, M., Gummer, D., Macbeth, B., Warren, A., Joseph, T., Li, H., Cunha, C.W., Duignan, P.J. 2016. Sheep-associated malignant catarrhal fever-like skin disease in a free-ranging bighorn sheep (Ovis canadensis), Alberta, Canada. Journal of Wildlife Diseases. 53(1):153-158.
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Replacement of glycoprotein B in alcelaphine herpesvirus 1 by its ovine herpesvirus 2 homolog: Implications in vaccine development for sheep-associated malignant catarrhal fever
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Cunha, C.W., Taus, N.S., Dewals, B.G., Vanderplasschen, A., Knowles, D.P., Li, H. 2016. Replacement of glycoprotein B in alcelaphine herpesvirus 1 by its ovine herpesvirus 2 homolog: Implications in vaccine development for sheep-associated malignant catarrhal fever. mSphere. doi:10.1128/mSphere.00108-16.
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Fibroblasts express OvHV-2 capsid protein in vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever
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Nelson, D.D., Taus, N.S., Schneider, D.A., Cunha, C.W., Davis, W.C., Brown, W.C., Li, H., O'Toole, D., Oaks, L.J. 2013. Fibroblasts express OvHV-2 capsid protein in vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever. Veterinary Microbiology. doi: 10.1016/j.vetmic.2013.07.021.
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Are rabbits a suitable model to study sheep-associated malignant catarrhal in susceptible hosts?
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Cunha, C.W., O'Toole, D., Taus, N.S., Knowles Jr, D.P., Li, H. 2013. Are rabbits a suitable model to study sheep-associated malignant catarrhal in susceptible hosts? Veterinary Microbiology. 163(3-4):358-363.
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Development of an in vivo system to measure antibody-blocking of ovine herpesvirus 2 entry
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Li, H., Cunha, C.W., O'Toole, D., Nicola, A.V., Knowles Jr, D.P., Taus, N.S. 2013. Development of an in vivo system to measure antibody-blocking of ovine herpesvirus 2 entry. Journal of Virological Methods. 188(1-2):104-107.
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Goats are a potential reservoir for the herpesvirus (MCFV-WTD),causing malignant catarrhal fever in deer
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Li, H., Cunha, C.W., Abbitt, B., Demaar, T.W., Lenz, S., Hayes, J.R., Taus, N.S. 2013. Goats are a potential reservoir for the herpesvirus (MCFV-WTD),causing malignant catarrhal fever in deer. Journal of Zoo and Wildlife Medicine. 44(2):484-486.
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Ovine herpesvirus 2 infection in american bison: virus and host dynamics in the development of sheep-associated malignant catarrhal fever
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Cunha, C.W., Gailbreath, K.L., O'Toole, D., Knowles Jr, D.P., Schneider, D.A., White, S.N., Taus, N.S., Davis, C.J., Davis, W.C., Li, H. 2012. Ovine herpesvirus 2 infection in american bison: virus and host dynamics in the development of sheep-associated malignant catarrhal fever. Veterinary Microbiology. 159:307-319.
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Experimental induction of malignant catarrhal fever in pigs with ovine herpesvirus 2 by intranasal nebulization
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Li, H., Brooking, A., Cunha, C.W., Highland, M.A., O'Toole, D., Knowles Jr, D.P., Taus, N.S. 2012. Experimental induction of malignant catarrhal fever in pigs with ovine herpesvirus 2 by intranasal nebulization. Veterinary Microbiology. 159(3-4):485-489. doi:10.1016/j.vetmic.2012.04.016.
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Malignant catarrhal fever: understanding molecular diagnostics in context of epidemiology
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Li, H., Cunha, C.W., Taus, N.S. 2011. Malignant catarrhal fever: understanding molecular diagnostics in context of epidemiology. International Journal of Molecular Sciences. 10:6881-6893.
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Characterization of ovine herpesvirus 2-induced malignant catarrhal fever in rabbits
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Li, H., Cunha, C.W., Gailbreath, K.L., O'Toole, D., White, S.N., Vanderplasschen, A., Dewals, B., Knowles Jr, D.P., Taus, N.S. 2011. Characterization of ovine herpesvirus 2-induced malignant catarrhal fever in rabbits. Veterinary Microbiology. 150(3-4):270-7.
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Development of a Multiplex Real-Time PCR for Detection and Differentiation of Malignant Catarrhal Fever Viruses in Clinical Samples
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Cunha, C.W., Otto, L., Taus, N.S., Knowles Jr, D.P., Li, H. 2009. Development of a Multiplex Real-Time PCR for Detection and Differentiation of Malignant Catarrhal Fever Viruses in Clinical Samples. Journal of Clinical Microbiology. 47(8):2586-2589.
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Experimental infection of rabbits with ovine herpesvirus 2 from sheep nasal secretions
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Gailbreath, K.L., Taus, N.S., Cunha, C.W., Knowles Jr, D.P., Li, H. 2008. Experimental infection of rabbits with ovine herpesvirus 2 from sheep nasal secretions. Veterinary Microbiology. 132:65-73.
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Ovine herpesvirus 2 replicates initially in the lung of experimentally infected sheep
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Li, H., Cunha, C.W., Davies, C.J., Gailbreath, K.L., Knowles Jr, D.P., Oaks, J.L., Taus, N.S. 2008. Ovine herpesvirus 2 replicates initially in the lung of experimentally infected sheep. Journal of General Virology. 89(7):1699-1708.
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Detection of ovine herpesvirus 2 major capsid gene transcripts as an indicator of virus replication in shedding sheep and clinically affected animals
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Cunha, C.W., Traul, D., Taus, N.S., Oaks, L., O'Toole, D., Davitt, C.M., Li, H. 2008. Detection of ovine herpesvirus 2 major capsid gene transcripts as an indicator of virus replication in shedding sheep and clinically affected animals. Virus Research. 132(1-2):69-75.
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