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ARS Home » People & Locations » Lauro Velazquez
Lauro Velazquez
Foreign Arthropod Borne Animal Disease Research
Visiting Scientist

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Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Interrogating genomes and geography to unravel multiyear vesicular stomatitis epizootics Reprint Icon - (Peer Reviewed Journal)
Humphreys Jr, J.M., Shults, P.T., Velazquez Salinas, L., Bertram, M.R., Pelzel-McCluskey, A.M., Peters, D.C., Rodriguez, L.L., Pauszek, S.J. 2024. Interrogating genomes and geography to unravel multiyear vesicular stomatitis epizootics. Viruses. 16(7). Article 1118. https://doi.org/10.3390/v16071118.
Deletion of the EP402R gene from the genome of African swine fever vaccine strain ASFV-G-deltaI177L provides the potential capability of differentiating between infected and vaccinated animals Reprint Icon - (Peer Reviewed Journal)
Borca, M.V., Ramirez Medina, E., Espinoza, N.N., Rai, A., Spinard III, E.J., Velazquez Salinas, L., Valladares, A., Silva, E.B., Burton, L.J., Meyers, A., Clark, J.A., Wu, P., Gay, C.G., Gladue, D.P. 2024. Deletion of the EP402R gene from the genome of African swine fever vaccine strain ASFV-G-deltaI177L provides the potential capability of differentiating between infected and vaccinated animals. Viruses. 16(3). Article 376. https://doi.org/10.3390/v16030376.
Evaluation of the deletion of the African swine fever virus gene O174L from the genome of the Georgia isolate Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., Velazquez Salinas, L., Rai, A., Espinoza, N.N., Valladares, A., Silva, E.B., Burton, L.J., Spinard III, E.J., Meyers, A., Risatti, G., Calvelage, S., Blome, S., Gladue, D.P., Borca, M.V. 2023. Evaluation of the deletion of the African swine fever virus gene O174L from the genome of the Georgia isolate. Viruses. 15(10). Article 2134. https://doi.org/10.3390/v15102134.
African swine fever vaccine candidate ASFV-g-deltaI177l produced in the swine macrophage-derived cell line IPKM remains genetically stable and protective against homologous virulent challenge Reprint Icon - (Peer Reviewed Journal)
Borca, M.V., Rai, A., Espinoza, N.N., Ramirez Medina, E., Spinard III, E.J., Velazquez Salinas, L., Valladares, A., Silva, E.B., Burton, L.J., Meyers, A., Gay, C.G., Gladue, D.P. 2023. African swine fever vaccine candidate ASFV-g-deltaI177l produced in the swine macrophage-derived cell line IPKM remains genetically stable and protective against homologous virulent challenge. Viruses. 5(10). Article 2064. https://doi.org/10.3390/v15102064.
African swine fever vaccine candidate ASFV-G-deltaI177L produced in the swine macrophage-derived cell line IPKM remains genetically stable and protective against homologous virulent challenge Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., Rai, A., Espinoza, N.N., Spinard III, E.J., Meyers, A., Valladares, A., Velazquez Salinas, L., Gay, C.G., Gladue, D.P., Borca, M.V., Silva, E.B., Burton, L.J., Clark, J.A. 2023. African swine fever vaccine candidate ASFV-G-deltaI177L produced in the swine macrophage-derived cell line IPKM remains genetically stable and protective against homologous virulent challenge. Pathogens. 15(10). Article 2064. https://doi.org/10.3390/v15102064.
Exploring the molecular basis of vesicular stomatitis virus pathogenesis in swine: insights from expression profiling of primary macrophages infected with M51R mutant virus Reprint Icon - (Peer Reviewed Journal)
Velazquez Salinas, L., Medina, G.N., Valdez, F., Collinson, S., Zarate, S., Zhu, J.J., Rodriguez, L.L. 2023. Exploring the molecular basis of vesicular stomatitis virus pathogenesis in swine: insights from expression profiling of primary macrophages infected with M51R mutant virus. Pathogens. 12(7). Article 896. https://doi.org/10.3390/pathogens12070896.
ASF vaccine candidate ASFV-G-deltaI177l does not exhibit residual virulence in long-term clinical studies Reprint Icon - (Peer Reviewed Journal)
Borca, M.V., Ramirez Medina, E., Silva, E.B., Ayushi, R., Espinoza, N.N., Velazquez Salinas, L., Gladue, D.P. 2023. ASF vaccine candidate ASFV-G-deltaI177l does not exhibit residual virulence in long-term clinical studies. Pathogens. 12(6). https://doi.org/10.3390/pathogens12060805.
Confirming the absence of parental African swine fever virus as a potential contaminant of recombinant live attenuated ASF vaccines Reprint Icon - (Peer Reviewed Journal)
Velazquez Salinas, L., Ramirez Medina, E., Rai, A., Pruitt, S.E., Vuono, E., Espinoza, N.N., Gay, C.G., Witte, S.B., Gladue, D.P., Borca, M.V. 2023. Confirming the absence of parental African swine fever virus as a potential contaminant of recombinant live attenuated ASF vaccines. Biologicals. 3;83:101685. https://doi.org/10.1016/j.biologicals.2023.101685.
Pathogenesis and transmissibility studies of the ASFV strain currently causing outbreaks in the Dominican Republic Reprint Icon - (Abstract Only)
Ramirez Medina, E., O'Donell, V., Silva, E.B., Espinoza, N.N., Velazquez Salinas, L., Moran, K., Daite, D., Barrette, R., Bonto, F., Holland, R., Gladue, D.P., Borca, M.V. 2023. Pathogenesis and transmissibility studies of the ASFV strain currently causing outbreaks in the Dominican Republic. Meeting Abstract. https://doi.org/10.3390/v14051090.
Evaluation of the function of ASFV gene E66L in the process of virus replication and virulence in swine Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., Vuono, E., Rai, A., Espinoza, N.N., Valladares, A., Spinard III, E.J., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2023. Evaluation of the function of ASFV gene E66L in the process of virus replication and virulence in swine. Viruses. 15(2). Article 566. https://doi.org/10.3390/v15020566.
Vesicular stomatitis Indiana virus near-full-length genome sequences reveal low genetic diversity during the 2019 outbreak in Colorado, USA Reprint Icon - (Peer Reviewed Journal)
Bertram, M.R., Rodgers, C., Reed, K., Velazquez Salinas, L., Pelzel-Mccluskey, A., Mayo, C., Rodriguez, L.L. 2023. Vesicular stomatitis Indiana virus near-full-length genome sequences reveal low genetic diversity during the 2019 outbreak in Colorado, USA. Frontiers in Veterinary Science. 10. Article 1110483. https://doi.org/10.3389/fvets.2023.1110483.
Deletion of an African swine fever ATP-dependent RNA hel-icase QP509L from the highly virulent Georgia 2010 strain does not affect replication or virulence Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., Vuono, E., Pruitt, S., Rai, A., Espinoza, N.N., Spinard III, E.J., Valadares, A., Silva, E.B., Velazquez Salinas, L., Borca, M.V., Gladue, D.P. 2022. Deletion of an African swine fever ATP-dependent RNA hel-icase QP509L from the highly virulent Georgia 2010 strain does not affect replication or virulence. Viruses. 14(11). https://doi.org/10.3390/v14112548.
ASFV Gene A151R is involved in the process of virulence in domestic swine Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., Vuono, E., Pruitt, S., Rai, A., Espinoza, N.N., Valladares, A., Spinard III, E.J., Silva, E.B., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2022. ASFV Gene A151R is involved in the process of virulence in domestic swine. Viruses. 14(8). Article 1834. https://doi.org/10.3390/v14081834.
Deletion of the EP296R gene from the genome of highly virulent African swine fever virus Georgia 2010 does not affect virus replication or virulence in domestic pigs Reprint Icon - (Abstract Only)
Vuono, E., Ramirez Medina, E., Pruitt, S.E., Rai, A., Espinoza, N.N., Spinard Iii, E.J., Valladares, A., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2022. Deletion of the EP296R gene from the genome of highly virulent African swine fever virus Georgia 2010 does not affect virus replication or virulence in domestic pigs. Virus Research. https://doi.org/10.3390/v14081682.
Deletion of the ASFV dUTPase gene E165R from the genome of highly virulent African swine fever virus Georgia 2010 does not affect virus replication or virulence in domestic pigs Reprint Icon - (Peer Reviewed Journal)
Vuono, E., Ramirez Medina, E., Pruitt, S.E., Rai, A., Espinoza, N.N., Silva, E.B., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2022. Deletion of the ASFV dUTPase gene E165R from the genome of highly virulent African swine fever virus Georgia 2010 does not affect virus replication or virulence in domestic pigs. Viruses. 14(7). Article 1409. https://doi.org/10.3390/v14071409.
Complete genome sequences of Foot-and-Mouth Disease Viruses of serotype O, EA-2 from cattle in Uganda during 2015-2016 Reprint Icon - (Peer Reviewed Journal)
Ahmed, Z., Frank, M.N., Velazquez Salinas, L., Vanderwaal, K., Jia, W., Rieder, A.E. 2022. Complete genome sequences of Foot-and-Mouth Disease Viruses of serotype O, EA-2 from cattle in Uganda during 2015-2016. Microbiology Resource Announcements. https://doi.org/10.1128/mra.00445-22.
Comparison of endemic and epidemic vesicular stomatitis virus lineages in Culicoides sonorensis midges Reprint Icon - (Peer Reviewed Journal)
Rozo-Lopez, P., Pauszek, S.J., Velazquez Salinas, L., Rodriguez, L.L., Park, Y., Drolet, B.S. 2022. Comparison of endemic and epidemic vesicular stomatitis virus lineages in Culicoides sonorensis midges. Viruses. 14(6):1221-1233. https://doi.org/10.3390/v14061221.
Deletion of H108R reduces virulence of the Georgia strain of African swine fever virus with surviving animals being protected against virulent challenge Reprint Icon - (Peer Reviewed Journal)
Vuono, E., Ramirez Medina, E., Silva, E.B., Rai, A., Pruitt, S.E., Espinoza, N.N., Valladares, A., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2022. Deletion of H108R reduces virulence of the Georgia strain of African swine fever virus with surviving animals being protected against virulent challenge. Journal of Virology. https://doi.org/10.1128/jvi.00545-22.
Experimental infection of domestic pigs with an African swine fever virus field strain isolated in 2021 from the Dominican Republic Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., O'Donnell, V., Silva, E.B., Espinoza, N.N., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2022. Experimental infection of domestic pigs with an African swine fever virus field strain isolated in 2021 from the Dominican Republic. Viruses. https://doi.org/10.3390/v14051090.
Deletion of E184L, a Putative DIVA Target from the Pandemic Strain of African Swine Fever Virus, Produces a Reduction in Virulence and Protection against Virulent Challenge Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., Vuono, E., Rai, A., Pruitt, S.E., Espinoza, N.N., Velazquez Salinas, L., Pina-Pedrero, S., Zhu, J.J., Rodriguez, F., Borca, M.V., Gladue, D.P. 2021. Deletion of E184L, a putative DIVA target from the pandemic strain of African Swine Fever Virus, produces a reduction in virulence and protection against virulent challenge. Viruses. https://doi.org/10.1128/JVI.01419-21.
Identification of genetic deletions in ASFV that could be potentially used as targets for the development of DIVA vaccines Reprint Icon - (Abstract Only)
Vuono, E., Ramirez Medina, E., Silva, E.B., Rai, A., Pruitt, S.E., Espinoza, N.N., Velazquez Salinas, L., Borca, M.V., Gladue, D.P. 2022. Identification of genetic deletions in ASFV that could be potentially used as targets for the development of DIVA vaccines. Meeting Abstract. https://doi.org/10.1128/JVI.01419-21.
Development real-time PCR assays to genetically differentiate vaccinated pigs from pigs infected with the Eurasian strain of African swine fever virus Reprint Icon - (Peer Reviewed Journal)
Velazquez Salinas, L., Ramirez Medina, E., Rai, A., Pruitt, S.E., Vuono, E.A., Espinoza, N.N., Gladue, D.P., Borca, M.V. 2021. Development real-time PCR assays to genetically differentiate vaccinated pigs from pigs infected with the Eurasian strain of African swine fever virus. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2021.768869.
Evaluation of the deletion of ASFV MGF110-5L-6L on swine virulence and its potential use as a DIVA vaccine marker gene Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., Vuono, E., Pruitt, S.E., Rai, A., Valladares, A., Espinoza, N.N., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2021. Evaluation of the deletion of ASFV MGF110-5L-6L on swine virulence and its potential use as a DIVA vaccine marker gene. Viruses. https://doi.org/10.3390/v13020286.