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Research Project: Predicting and Mitigating Vesicular Stomatitis Virus (VSV) Outbreaks in North America

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Title: Vesicular stomatitis Indiana virus near-full-length genome sequences reveal low genetic diversity during the 2019 outbreak in Colorado, USA

Author
item Bertram, Miranda
item RODGERS, CASE - Colorado State University
item REED, KIRSTEN - Colorado State University
item Velazquez, Lauro
item PELZEL-MCCLUSKEY, ANGELA - Animal And Plant Health Inspection Service (APHIS)
item MAYO, CHRISTIE - Colorado State University
item Rodriguez, Luis

Submitted to: Frontiers in Veterinary Science
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/30/2023
Publication Date: 2/14/2023
Citation: Bertram, M.R., Rodgers, C., Reed, K., Velazquez Salinas, L., Pelzel-Mccluskey, A., Mayo, C., Rodriguez, L.L. 2023. Vesicular stomatitis Indiana virus near-full-length genome sequences reveal low genetic diversity during the 2019 outbreak in Colorado, USA. Frontiers in Veterinary Science. 10. Article 1110483. https://doi.org/10.3389/fvets.2023.1110483.
DOI: https://doi.org/10.3389/fvets.2023.1110483

Interpretive Summary: Vesicular stomatitis virus (VSV) causes an economically important disease in livestock, with outbreaks in the USA about every 5-10 years. There are two sub-types of the virus, New Jersey (VSNJV) and Indiana (VSIV). Most of the outbreaks in the USA have been caused by VSNJV, which is considered to be the more virulent strain. However, in 2019 VSIV caused the largest VSV outbreak in the USA in the past 40 years, and Colorado was heavily affected. We sequenced the VSIV viruses from samples collected in Colorado in 2019. These full-length genome sequences will be used to investigate the epidemiology, ecology, and evolution of the virus to understand why this VSIV strain caused a widespread outbreak in 2019.

Technical Abstract: The paucity of full-length vesicular stomatitis virus (VSV) sequences, and particularly vesicular stomatitis virus - Indiana (VSIV) sequences, currently available in public databases limits understanding of the genetic basis associated with the emergence of epidemic lineages. The goal of this project was to produce a collection of VSIV genomes representing an epidemic lineage circulating in the US. We report herein 86 near-full-length genomes obtained from VSIV isolates collected from naturally infected horses in 27 counties of Colorado during 2019.