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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Exotic & Emerging Avian Viral Diseases Research » People & Locations » Chang Lee
Chang Lee
Exotic & Emerging Avian Viral Diseases Research
Microbiologist

Phone: (706) 546-3209
Fax:

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Projects
Control Strategies to Prevent and Respond to Diseases Outbreaks Caused by Avian Influenza Viruses
In-House Appropriated (D)
  Accession Number: 441119
Intervention Strategies to Predict, Prevent, and Control Emerging Strains of Virulent Newcastle Disease Viruses
In-House Appropriated (D)
  Accession Number: 441214
Improving Prevention of Newcastle Disease by Identification of Emerging Strains, Virus Evolution and Predicting Protection Conferred by Vaccination
Non-Assistance Cooperative Agreement (S)
  Accession Number: 440783

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Efficacy of commercial recombinant HVT vaccines against a North American clade 2.3.4.4b H5N1 Highly Pathogenic Avian Influenza Virus in chickens Reprint Icon - (Peer Reviewed Journal)
Lee, J., Lee, C.W., Suarez, D.L., Lee, S.A., Kim, T.N., Spackman, E. 2024. Efficacy of commercial recombinant HVT vaccines against a North American clade 2.3.4.4b H5N1 Highly Pathogenic Avian Influenza Virus in chickens. PLOS ONE. 19(7):e307100. https://doi.org/10.1371/journal.pone.0307100.
Investigating the uses of machine learning algorithms to inform risk factor analyses: the example of avian infectious bronchitis virus (IBV) in boiler chickens Reprint Icon - (Peer Reviewed Journal)
Campler, M.R., Cheng, T., Lee, C.W., Hofacre, C.L., Lossie, G., Silva, G.S., El-Gazzar, M.M., Arruda, A.G. 2024. Investigating the uses of machine learning algorithms to inform risk factor analyses: the example of avian infectious bronchitis virus (IBV) in boiler chickens. Research in Veterinary Science. 171(2024):105201. https://doi.org/10.1016/j.rvsc.2024.105201.
TLR3 and MDA5 knockout DF-1 cells enhance replication of avian orthoavulavirus 1 Reprint Icon - (Peer Reviewed Journal)
Lee, C.W., Mahesh, K.C., Ngunjiri, J.M., Ghorbani, A., Lee, K. 2023. TLR3 and MDA5 knockout DF-1 cells enhance replication of avian orthoavulavirus 1. Avian Diseases. 67(1):94-101. https://doi.org/10.1637/aviandiseases-D-22-00065.
Efficacy of inactivated and RNA particle vaccines against a North American clade 2.3.4.4b H5 highly pathogenic avian influenza virus Reprint Icon - (Peer Reviewed Journal)
Spackman, E., Suarez, D.L., Lee, C.W., Pantin Jackwood, M.J., Lee, S.A., Youk, S., Ibrahim, S. 2023. Efficacy of inactivated and RNA particle vaccines against a North American clade 2.3.4.4b H5 highly pathogenic avian influenza virus. Vaccine. 41(49):7369-7376. https://doi.org/10.1016/j.vaccine.2023.10.070.
Diversity and complexity of internally deleted viral genomes in influenza A virus subpopulations with enhanced interferon-inducing phenotypes Reprint Icon - (Peer Reviewed Journal)
Ghorbani, A., Ngunjiri, J.M., Rendon, G., Brooke, C.B., Kenney, S.P., Lee, C.W. 2023. Diversity and complexity of internally deleted viral genomes in influenza A virus subpopulations with enhanced interferon-inducing phenotypes. Viruses. 15(10):2107. https://doi.org/10.3390/v15102107.
Toll-like receptor ligands enhance vaccine efficacy against a virulent Newcastle disease virus challenge in chickens Reprint Icon - (Peer Reviewed Journal)
Lee, C.W., Bakre, A.A., Olivier, T.L., Alvarez Narvaez, S., Harrell, T.L., Conrad, S.J. 2023. Toll-like receptor ligands enhance vaccine efficacy against a virulent Newcastle disease virus challenge in chickens. Pathogens. 12(10):1230. https://doi.org/10.3390/pathogens12101230.
Development of in ovo-compatible NS1-truncated live attenuated influenza vaccines by modulation of hemagglutinin cleavage and polymerase acidic x frameshifting sites Reprint Icon - (Peer Reviewed Journal)
Ghorbani, A., Ngunjiri, J.M., Abundo, M.C., Pantin Jackwood, M.J., Kenney, S.P., Lee, C.W. 2023. Development of in ovo-compatible NS1-truncated live attenuated influenza vaccines by modulation of hemagglutinin cleavage and polymerase acidic x frameshifting sites. Vaccine. 41(11):1848-1858. https://doi.org/10.1016/j.vaccine.2023.01.018.
Genome sequencing and characterization of an avian orthoavulavirus 1 VG/GA-like isolate with a unique fusion cleavage site motif Reprint Icon - (Peer Reviewed Journal)
Kariithi, H.M., Suarez, D.L., Davis, J.F., Dufour-Zavala, L., Olivier, T.L., Williams Coplin, T.D., Bakre, A.A., Lee, C.W. 2023. Genome sequencing and characterization of an avian orthoavulavirus 1 VG/GA-like isolate with a unique fusion cleavage site motif. Avian Diseases. 67(1):33-41. https://doi.org/10.1637/aviandiseases-D-22-00064.
Pathogenesis of H5N1 avian influenza virus gene reassortants in chickens - (Abstract Only)
Pantin Jackwood, M.J., Lee, C.W., Kapczynski, D.R., Sarmento, L., Wasilenko, J.L., Spackman, E., Suarez, D.L. 2007. Pathogenesis of H5N1 avian influenza virus gene reassortants in chickens [abstract]. Options for the Control of Influenza VI Conference, Abstract book. June 17-23, 2007, Toronto, Canada. p. 260.
INACTIVATED NORTH AMERICAN AND EUROPEAN H5N2 AVIAN INFLUENZA VIRUS VACCINES PROTECT CHICKENS FROM ASIAN H5N1 HIGH PATHOGENICITY AVIAN INFLUENZA VIRUS - (Peer Reviewed Journal)
Swayne, D.E., Lee, C.W., Spackman, E. 2006. Inactivated North American and European H5N2 avian influenza virus vaccines protect chickens from Asian H5N1 high pathogenicity avian influenza virus. Avian Pathology. 35(2):141-146.
PROTECTIVE EFFICACY OF INACTIVATED INFLUENZA VACCINES AGAINST HIGHLY PATHOGENIC ASIAN H5N1 AVIAN INFLUENZA VIRUSES IN CHICKENS - (Abstract Only)
Jadhao, S.J., Lee, C.W., Suarez, D.L. 2006. Protective efficacy of inactivated influenza vaccines against highly pathogenic Asian H5N1 avian influenza viruses in chickens [abstract]. American Association of Avian Pathologists. CD p. 77.
ELISA TEST FOR THE DIFFERENTIATION OF INFECTED AND VACCINATED ANIMALS (DIVA) USING A NATURAL TRUNCATED NS1 PROTEIN OF AVIAN INFLUENZA VIRUS - (Abstract Only)
DEVELOPMENT AND APPLICATION OF REFERENCE ANTISERA AGAINST 15 HEMAGGLUTININ SUBTYPES OF INFLUENZA VIRUS BY DNA VACCINATION OF CHICKENS - (Peer Reviewed Journal)
Lee, C.W., Senne, D.A., Suarez, D.L. 2006. Development and application of reference antisera against 15 hemagglutinin subtypes of influenza virus by DNA vaccination of chickens. Clinical and Vaccine Immunology. p. 395-402.
EVOLUTION OF H5N1 AVIAN INFLUENZA VIRUSES IN ASIA: ANTIGENICITY, ANTIVIRAL DRUG SENSITIVITY AND VACCINE DEVELOPMENT - (Peer Reviewed Journal)
Donis, R., Lee, C.W., Suarez, D.L., Spackman, E., Swayne, D.E. 2005. Evolution of H5N1 avian influenza viruses in asia: antigenicity, antiviral drug sensitivity and vaccine development. Emerging Infectious Diseases. 10:1515-1521.
AVIAN INFLUENZA VACCINATION IN NORTH AMERICA: STRATEGIES AND DIFFICULTIES - (Peer Reviewed Journal)
Suarez, D.L., Lee, C.W., Swayne, D.E. 2006. Avian influenza vaccination in North America: strategies and difficulties. Developments in Biologicals. 124: 117-124.
H5N2 AVIAN INFLUENZA A IN A RED-LORED AMAZON PARROT (AMAZONA AUTUMNALIS AUTUMNALIS) - (Peer Reviewed Journal)
Hawkins, M.G., Crossley, B.M., Osofsky, A., Webby, R.J., Lee, C.W., Suarez, D.L., Hietala, S.K. 2006. H5N2 avian influenza a in a red-lored amazon parrot (amazona autumnalis autumnalis). Journal of the American Veterinary Medical Association. 228(2):236-241.
H5N2 AVIAN INFLUENZA OUTBREAK IN TEXAS IN 2004: THE FIRST HIGHLY PATHOGENIC STRAIN IN THE UNITED STATES IN 20 YEARS? - (Peer Reviewed Journal)
Lee, C.W., Swayne, D.E., Linares, J.A., Senne, D.A., Suarez, D.L. 2005. H5N2 avian influenza outbreak in Texas in 2004: the first highly pathogenic strain in the United States in 20 years?. Journal of Virology. 79(17):11412-11421.
AVIAN INFLUENZA VIRUS: PROSPECTS FOR PREVENTION AND CONTROL BY VACCINATION - (Peer Reviewed Journal)
Lee, C.W., Suarez, D.L. 2005. Avian influenza virus: prospects for prevention and control by vaccination. Animal Health Research Reviews. 6(1):1-15.
ISOLATION AND CHARACTERIZATION OF H3N2 INFLUENZA A VIRUS FROM TURKEYS - (Peer Reviewed Journal)
Tang, Y., Lee, C.W., Zhang, Y., Senne, D.A., Dearth, R., Byrum, B., Perez, D., Suarez, D.L., Saif, Y.M. 2005. Isolation and characterization of h3n2 influenza a virus from turkeys. Avian Diseases 49:207-213.
CHARACTERIZATION OF HIGHLY PATHOGENIC H5N1 AVIAN INFLUENZA A VIRUSES ISOLATED FROM KOREAN POULTRY - (Peer Reviewed Journal)
Lee, C.W., Suarez, D.L., Tumpey, T.M., Sung, H., Kwon, Y., Lee, Y., Choi, J., Joh, S., Kim, M., Lee, E., Park, J., Lu, X., Katz, J.M., Spackman, E., Swayne, D.E., Kim, J. 2005. Characterization of highly pathogenic h5n1 avian influenza a viruses isolated from korean poultry. Journal of Virology. 79:3692-3702.
APPLICATION OF REAL-TIME RT-PCR FOR THE QUANTIFICATION AND COMPETITIVE REPLICATION STUDY OF H5 AND H7 SUBTYPE AVIAN INFLUENZA VIRUS - (Peer Reviewed Journal)
Lee, C.W., Suarez, D.L. 2004. Application Of Real-Time RT-PCR For The Quantification And Competitive Replication Study Of H5 and H7 Subtype Avian Influenza Virus. Journal of Virological Methods, 2004 v.119, p.151-158.
EFFECT OF VACCINE USE IN THE EVOLUTION OF MEXICAN-LINEAGE H5N2 AVIAN INFLUENZA VIRUS - (Peer Reviewed Journal)
Lee, C.W., Senne, D.A., Suarez, D.L. 2004. Effect of vaccine use in the evolution of mexican-lineage h5n2 avian influenza virus. Journal of Virology. Aug. 2004, p 8372-8381.
CHARACTERIZATION OF RECENT H5 SUBTYPE AVIAN INFLUENZA VIRUSES FROM U.S. POULTRY - (Peer Reviewed Journal)
Lee, C.W., Senne, D., Linares, J.A., Woolcock, P., Stallknecht, D., Spackman, E., Swayne, D.E., Suarez, D.L. 2004. Characterization Of Recent H5 Subtype Avian Influenza Viruses From U.S. Poultry. Avian Pathology June 2004, 33(3), p.288-297.
GENERATION OF REASSORTANT INFLUENZA VACCINES BY REVERSE GENETICS THAT ALLOWS UTILIZATION OF A DIVA (DIFFERENTIATING INFECTED FROM VACCINATED ANIMALS)STRATEGY FOR THE CONTROL OF AVIAN INFLUENZA - (Peer Reviewed Journal)
Lee, C.W., Senne, D., Suarez, D.L. 2004. Generation of Reassortant Influenza Vaccines By Reverse Genetics That Allows Utilization Of A Diva (Differentiating Infected From Vaccinated Animals)Strategy For The Control Of Avian Influenza. Vaccine 22(2004) 3175-3181.
DEVELOPMENT AND VALIDATION OF A REAL-TIME RT-PCR TEST FOR AVIAN PARAMYXOVIRUS TYPE 1 AND EXOTIC NEWCASTLE DISEASE VIRUS - (Abstract Only)
Spackman, E., Wise, M., Suarez, D.L., Senne, D.A., Pedersen, J.C., King, D.J., Swayne, D.E., Lee, C.W., Seal, B.S. 2003. Development and Validation of a Real-Time RT-PCR Test for Avian Paramyxovirus Type 1 and Exotic Newcastle Disease Virus. American Association of Veterinary Laboratory Diagnosticians.