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ARS Home » Research » Publications at this Location » Publication #189261
Title: PROTECTIVE EFFICACY OF INACTIVATED INFLUENZA VACCINES AGAINST HIGHLY PATHOGENIC ASIAN H5N1 AVIAN INFLUENZA VIRUSES IN CHICKENS

Author
item JADHAO, SAMADHAN - USDA-ARS-SEPRL
item Lee, Chang
item Suarez, David

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: 1/18/2006
Publication Date: 7/16/2006
Citation: Jadhao, S.J., Lee, C.W., Suarez, D.L. 2006. Protective efficacy of inactivated influenza vaccines against highly pathogenic Asian H5N1 avian influenza viruses in chickens [abstract]. American Association of Avian Pathologists. CD p. 77.

Interpretive Summary:

Technical Abstract: We evaluated the efficacy of vaccines prepared from Asian and American avian influenza viruses (AIVs) to protect chickens from lethal challenge with highly pathogenic (HP) Asian H5N1 AIVs. Vaccination studies were conducted in two week old chickens using inactivated vaccines prepared from reverse genetics rescued viruses or American wild type viruses, A/Turkey/Wisconsin/68 (H5N9) or A/Chicken/Mexico/232/94 (H5N2). The reverse genetics viruses used the hemagglutinin gene of A/Chicken/Indonesia/7/2003, a HP virus that was modified to be low pathogenic with different neuraminidase and internal genes. Oro-nasal challenge of vaccinated birds with a lethal dose of either A/Chicken/Indonesia/07/03 or A/Chicken/Supuranburi/2/04 virus showed all three vaccines provided good protection for chickens. Additionally, some of the vaccines could be used to differentiate infected from vaccinated animals because of different neuraminidase antibody responses.