Research Project: Technologies for Producing Renewable Bioproducts

Location: Renewable Product Technology Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Harnessing synthetic biology based strategies for engineered biosynthesis of nucleoside natural products in actinobacteria - (Literature Review)
Gong, R., Yu, L., Price, N.P., He, X., Deng, Z., Chen, W. 2020. Harnessing synthetic biology based strategies for engineered biosynthesis of nucleoside natural products in actinobacteria. Biotechnology Advances. 46. Article 107673. https://doi.org/10.1016/j.biotechadv.2020.107673.

Exploring the active site of the antibacterial target MraY by modified tunicamycins - (Peer Reviewed Journal)
Hering, J., Dunevall, E., Snijder, A., Eriksson, P., Jackson, M.A., Hartman, T.M., Ting, R., Chen, H., Price, N.P., Branden, G., Ek, M. 2020. Exploring the active site of the antibacterial target MraY by modified tunicamycins. ACS Chemical Biology. 15(11):2885-2895. https://doi.org/10.1021/acschembio.0c00423.

Rhodium-catalyzed reductive modification of pyrimidine nucleosides, nucleotide phosphates, and sugar nucleotides - (Peer Reviewed Journal)
Price, N.P., Jackson, M.A., Vermillion, K., Blackburn, J.A., Hartman, T.M. 2019. Rhodium-catalyzed reductive modification of pyrimidine nucleosides, nucleotide phosphates, and sugar nucleotides. Carbohydrate Research. 488. Article 107893. https://doi.org/10.1016/j.carres.2019.107893.

Divergent biosynthesis of C-Nucleoside minimycin and indigoidine in bacteria - (Peer Reviewed Journal)
Kong, L., Xu, G., Liu, X., Wang, J., Tang, Z., Cai, Y., Shen, K., Tao, W., Zheng, Y., Deng, Z., Price, N.P.J., Chen, W. 2019. Divergent biosynthesis of C-Nucleoside minimycin and indigoidine in bacteria. iScience. 22:430–440. https://doi.org/10.1016/j.isci.2019.11.037.

Comparative investigation into formycin A and pyrazofurin A biosynthesis reveals branch pathways for the construction of C-nucleoside scaffolds - (Peer Reviewed Journal)
Zhang, M., Zhang, P., Xu, G., Zhou, W., Gao, Y., Gong, R., Cai, Y., Cong, H., Deng, Z., Price, N.P.J, Chen, W., Mao, X. 2019. Comparative investigation into formycin A and pyrazofurin A biosynthesis reveals branch pathways for the construction of C-nucleoside scaffolds. ACS Chemical Biology. https://doi.org/10.1101/728154.

Synergistic enhancement of beta-lactam antibiotics by modified tunicamycin analogs TunR1 and TunR2 - (Peer Reviewed Journal)
Price, N.J.P., Jackson, M.A., Singh, V., Hartman, T.M., Dowd, P.F., Blackburn, J.A. 2019. Synergistic enhancement of beta-lactam antibiotics by modified tunicamycin analogs TunR1 and TunR2. Journal of Antibiotics. 72(11):807-815. https://doi.org/10.1038/s41429-019-0220-x.

Characterization of a glucansucrase from Lactobacillus reuteri E81 and production of malto-oligosaccharides - (Peer Reviewed Journal)
Ispirli, H., Yüzer, M., Skory, C.D., Colquhoun, I., Sagdiç, O., Dertli, E. 2019. Characterization of a glucansucrase from Lactobacillus reuteri E81 and production of malto-oligosaccharides. Biocatalysis and Biotransformation. 37:6, 421-430.. https://doi.org/10.1080/10242422.2019.1593969.

Characterization of a 4,6-a-glucanotransferase from Lactobacillus reuteri E81 and production of malto-oligosaccharides with immune-modulatory roles - (Peer Reviewed Journal)
Ispirli, H., Simsek, Ö., Skory, C.D., Sagdic, O., Dertli, E. 2018. Characterization of a 4,6-a-glucanotransferase from Lactobacillus reuteri E81 and production of malto-oligosaccharides with immune-modulatory roles. International Journal of Biological Macromolecules. 124:1213-1219. https://doi.org/10.1016/j.ijbiomac.2018.12.050.

Coordinated biosynthesis of the purine nucleoside antibiotics aristeromycin and coformycin in the actinomycetes - (Peer Reviewed Journal)
Xu, G., Kong, L., Xu, L., Gao, Y., Jiang, M., Cai, Y., Hong, K., Deng, Z., Price, N.P.J., Chen, W., Yu, Y. 2018. Coordinated biosynthesis of the purine nucleoside antibiotics aristeromycin and coformycin in the actinomycetes. Applied and Environmental Microbiology. 34(22):e01860-18. https://doi.org/10.1128/aem.01860-18.

Thiazolidine peracetates: carbohydrate derivatives that readily assign cis-, trans-2,3- monosaccharides by gas chromatography - mass spectrometry analysis - (Peer Reviewed Journal)
Price, N.P.J., Hartman, T.M., Vermillion, K.E. 2018. Thiazolidine peracetates: carbohydrate derivatives that readily assign cis-, trans-2,3- monosaccharides by gas chromatography - mass spectrometry analysis. Analytical Chemistry. 90(13):8044-8050. doi:10.1021/acs.analchem.8b00976.

Genome sequences of five Lactobacillus sp. isolates from traditional Turkish sourdough - (Other)
Dertli, E., Skory, C.D., Simsek, Ö. 2018. Genome sequences of five Lactobacillus sp. isolates from traditional Turkish sourdough. Genome Announcements. 6(26)1-2. https://doi.org/10.1128/genomeA.00616-18.

An ATP-dependent ligase with substrate flexibility involved in assembly of the peptidyl nucleoside antibiotic polyoxin - (Peer Reviewed Journal)
Gong, R., Qi, J., Wu, P., Cai, Y., Ma, H., Liu, Y., Duan, H., Wang, M., Deng, Z., Price, N.P.J., Chen, W. 2018. An ATP-dependent ligase with substrate flexibility involved in assembly of the peptidyl nucleoside antibiotic polyoxin. Applied and Environmental Microbiology. doi: 10.1128/AEM.00501-18.

Medium optimization for production of anti-streptococcal liamocins by Aureobasidium pullulans - (Peer Reviewed Journal)
Leathers, T.D., Skory, C.D., Price, N.P.J., Nunnally, M.S. 2017. Medium optimization for production of anti-streptococcal liamocins by Aureobasidium pullulans. Biocatalysis and Agricultural Biotechnology. 13:53-57. doi: 10.1016/j.bcab.2017.11.008.

Production of isomelezitose from sucrose by engineered glucansucrases - (Peer Reviewed Journal)
Cote, G.L., Dunlap, C.A., Vermillion, K.E., & Skory, C.D. 2017. Production of isomelezitose from sucrose by engineered glucansucrases. Amylase. 1(1):82-93. doi: 10.1515/amylase-2017-0008.

Selective catalytic hydrogenation of the N-acyl and uridyl double bonds in the tunicamycin family of protein N-glycosylation inhibitors - (Peer Reviewed Journal)
Price, N.P.J., Jackson, M.A., Vermillion, K.E., Blackburn, J.A., Li, J., & Yu, B. 2017. Selective catalytic hydrogenation of the N-acyl and uridyl double bonds in the tunicamycin family of protein N-glycosylation inhibitors. Journal of Antibiotics. 70:1122-1128. doi: 10.1038/ja.2017.141.

Structural analysis of the alpha-D-glucan produced by the sourdough isolate Lactobacillus brevis E25 - (Peer Reviewed Journal)
Dertli, E., Colquhoun, I.J., Cote, G.L., Le Gall, G., Narbad, A. 2018. Structural analysis of the alpha-D-glucan produced by the sourdough isolate Lactobacillus brevis E25. Food Chemistry. 242:45-52. doi: 10.1016/j.foodchem.2017.09.017.

Antibacterial liamocins with alternative carbohydrate headgroups - (Abstract Only)
Leathers, T.D., Price, N.P., Skory, C.D. 2017. Antibacterial liamocins with alternative carbohydrate headgroups [abstract]. American Chemical Society National Meeting, August 20-24, 2017, Washington, D.C. No. 2736606.

Reduced-molecular-weight derivatives of frost grape polysaccharide - (Peer Reviewed Journal)
Leathers, T.D., Price, N.P.J., Vaughn, S.F., Nunnally, M.S. 2017. Reduced-molecular-weight derivatives of frost grape polysaccharide. International Journal of Biological Macromolecules. 105:1166-1170. doi: 10.1016/j.ijbiomac.2017.07.143.

Thiazolidine peracetates: Novel carbohydrate derivatives that assign cis-2,3- from trans-2,3- monosaccharides by GC/MS analysis - (Abstract Only)
Price, N.P., Hartman, T.M., Vermillion, K. 2017. Thiazolidine peracetates: Novel carbohydrate derivatives that assign cis-2,3- from trans-2,3- monosaccharides by GC/MS analysis [abstract]. Gordon Research Conference on Carbohydrates: Chemical and Biochemical Approaches to Deciphering Glycan Functions, June 25-30, 2017, West Dover, NH.

Isomelezitose formation by glucansucrases - (Peer Reviewed Journal)
Cote, G.L., Skory, C.D. 2017. Isomelezitose formation by glucansucrases. Carbohydrate Research. 439:57-60.

Evaluation of carbohydrate-cysteamine thiazolidines as pro-drugs for the treatment of cystinosis - (Peer Reviewed Journal)
Ramazani, Y., Levtchenko, E.N., Van Den Heuvel, L., Van Schepdael, A., Prasanta, P., Ivanova, E.A., Pastore, A., Hartman, T.M., Price, N.P.J. 2017. Evaluation of carbohydrate-cysteamine thiazolidines as pro-drugs for the treatment of cystinosis. Carbohydrate Research. 439:9-15.

Production of anti-streptococcal liamocins from agricultural biomass by Aureobasidium pullulans - (Peer Reviewed Journal)
Leathers, T.D., Price, N.P.J., Manitchotpisit, P., Bischoff, K.M. 2016. Production of anti-streptococcal liamocins from agricultural biomass by Aureobasidium pullulans. World Journal of Microbiology and Biotechnology. 32(12):199. doi: 10.1007/s11274-016-2158-5.

Polyols, not sugars, determine the structural diversity of anti-streptococcal liamocins produced by Aureobasidium pullulans strain NRRL 50380 - (Peer Reviewed Journal)
Price, N.P.J., Bischoff, K.M., Leathers, T.D., Cosse, A.A., Manitchotpisit, P. 2016. Polyols, not sugars, determine the structural diversity of anti-streptococcal liamocins produced by Aureobasidium pullulans strain NRRL 50380. Journal of Antibiotics. 70(2):136-141. doi: 10.1038/ja.2016.92.

Effect of a single point mutation on the interaction of glucans with a glucansucrase from Leuconostoc mesenteroides NRRL B-1118 - (Peer Reviewed Journal)
Cote, G.L., Skory, C.D. 2016. Effect of a single point mutation on the interaction of glucans with a glucansucrase from Leuconostoc mesenteroides NRRL B-1118. Carbohydrate Research. 428:57-61.

Biochemical conversion of sugar to novel renewable products and materials - (Abstract Only)
Skory, C.D., Cote, G.L., Leathers, T.D., Cormier, R., Rich, J.O. 2016. Biochemical conversion of sugar to novel renewable products and materials [abstract]. Advances in Sugar Crop Processing and Conversion.

The role of aquaporins in pH-Dependent germination of Rhizopus delemar spores - (Peer Reviewed Journal)
Turgeman, T., Shatil-Cohen, A., Moshelion, M., Teper-Bamnolker, P., Skory, C.D., Lichter, A., Eshel, D. 2016. The role of aquaporins in pH-dependent germination of Rhizopus delemar spores. PLoS One. 11(3)e0150543. doi: 10.1371/journal.pone.0150543.

Modification of the mannitol biosynthetic pathway in Aureobasidium pullulans to alter the structure of the polyol lipid liamocin - (Abstract Only)
Skory, C.D., Price, N.P.J., Leathers, T.D., Manitchotpisit, P., Hector, R.E., Bowman, M.J., Rich, J.O. 2016. Modification of the mannitol biosynthetic pathway in Aureobasidium pullulans to alter the structure of the polyol lipid liamocin [abstract]. Society for Industrial Microbiology and Biotechnology. Poster P39, Paper 32487.

Effect of a single point mutation on the interaction of glucans with a glucansucrase from Leuconostoc mesenteroides NRRL B-1118 - (Abstract Only)
Cote, G.L., Skory, C.D. 2016. Effect of a single point mutation on the interaction of glucans with a glucansucrase from Leuconostoc mesenteroides NRRL B-1118 [abstract]. International Carbohydrate Symposium. p. 93.

Quinovosamycins: New tunicamycin-type antibiotics in which the alpha, beta-1", 11'-linked N-acetylglucosamine residue is replaced by N-acetylquinovosamine. - (Peer Reviewed Journal)
Price, N.P.J., Labeda, D.P., Naumann, T.A., Vermillion, K.E., Bowman, M.J., Berhow, M.A., Metcalf, W.W., Bischoff, K.M. 2016. Quinovosamycins: New tunicamycin-type antibiotics in which the alpha, beta-1", 11'-linked N-acetylglucosamine residue is replaced by N-acetylquinovosamine. Journal of Antibiotics. 69(8):637-646. doi: 10.1038/ja.2016.49.

Integrated genomics of Mucorales reveals novel therapeutic targets - (Peer Reviewed Journal)
Chibucos, M.C., Soliman, S., Gebremariam, T., Lee, H., Daugherty, S., Orvis, J., Shetty, A.C., Crabtree, J., Hazen, T.H., Etienne, K.A., Kumari, P., O'Connor, T.D., Rasko, D.A., Filler, S.G., Frazer, C.M., Lockhart, S.R., Skory, C.D., Ibrahim, A.S., Bruno, V.M. 2016. An integrated genomic and transcriptomic survey of mucormycosis-causing fungi. Nature Communications. 7:12218. doi: 10.1038/ncomms12218.

Liamocins from Aureobasidium pullulans: New and highly selective anti-streptococcal agents - (Abstract Only)
Price, N.P., Bischoff, K.M., Manitchotpisit, P., Leathers, T.D., Rich, J.O. 2015. Liamocins from Aureobasidium pullulans: New and highly selective anti-streptococcal agents [abstract]. University of Illinois College of Medicine at Peoria.

Lactic acid production from Cellobiose and xylose by engineered Saccharomyces cerevisiae - (Peer Reviewed Journal)
Turner, T.L., Zhang, G.C., Oh, E.J., Subramaniam, V., Adiputra, A., Subramaniam, V., Skory, C.D., Jang, J.Y., Yu, B.J., Park, I., Jin, Y.S. 2015. Lactic acid production from cellobiose and xylose by engineered Saccharomyces cerevisiae. Biotechnology and Bioengineering. 113(5):1075-1083. doi: 10.1002/bit.25875.

Tunicamycins: translocase-I inhibitors that target bacterial cell wall and mammalian N-glycoproteins. The potential for selective inhibitors - (Abstract Only)
Price, N.P. 2015. Tunicamycins: Translocase-I inhibitors that target bacterial cell wall and mammalian N-glycoproteins. The potential for selective inhibitors [abstract]. Glycobiology World Congress.

A novel emulsion-forming arabinogalactan gum from the stems of Frost grape (Vitis riparia Michx.) - (Abstract Only)
Price, N.P., Vermillion, K., Eller, F.J., Vaughn, S.F. 2015. A novel emulsion-forming arabinogalactan gum from the stems of Frost grape (Vitis riparia Michx.) [abstract]. Phytochemical Society of North America.