Research Project: Diagnostic and Control Strategies for Malignant Catarrhal Fever

Location: Animal Disease Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Ovine gammaherpesvirus-2 infection associated with chronic interstitial pneumonia in a sheep - (Peer Reviewed Journal)
Headley, S.A., Dall Agnol, A.M., Navolar, F.M., Frucchi, A.P., de Matos, A.M., Pereira, P.F., Xavier, A.A., Santos, V.H., Silva, L.E., Depes, V.C., Alfieri, A.F., Cunha, C.W., Alfieri, A.A. 2021. Ovine gammaherpesvirus-2 infection associated with chronic interstitial pneumonia in a sheep. Microbial Pathogenesis. 161. Article 105220. https://doi.org/10.1016/j.micpath.2021.105220.

A screening for virus infections in eight herds of semi-domesticated Eurasian tundra reindeer (Rangifer tarandus tarandus) in Norway, 2013–2018 - (Peer Reviewed Journal)
Tryland, M., Sánchez Romano, J., Nymo, I.H., Breines, E.M., Ancin Murguzur, F.J., Kjenstad, O.C., Li, H., Cunha, C.W. 2021. A screening for virus infections in eight herds of semi-domesticated Eurasian tundra reindeer (Rangifer tarandus tarandus) in Norway, 2013–2018. Frontiers in Veterinary Science. 8. Article 707787. https://doi.org/10.3389/fvets.2021.707787.

The participation of a malignant catarrhal fever virus and Mycoplasma bovis in the development of single and mixed infections in beef and dairy cattle with bovine respiratory disease - (Peer Reviewed Journal)
Oliveira, T.E., Scuisato, G.S., Pelaquim, I.F., Cunha, C.W., Cunha, L.S., Flores, E.F., Pretto-Giordano, L.G., Lisboa, J.A., Alfieri, A.A., Saut, J.P., Cunha, P.H., Headley, S.A. 2021. The participation of a malignant catarrhal fever virus and Mycoplasma bovis in the development of single and mixed infections in beef and dairy cattle with bovine respiratory disease. Frontiers in Veterinary Science. 8. Article 691448. https://doi.org/10.3389/fvets.2021.691448.

OvHV-2 glycoprotein B delivered by a recombinant BoHV-4 is immunogenic and induces partial protection against sheep-associated malignant catarrhal fever in a rabbit model - (Peer Reviewed Journal)
Shringi, S., O'Toole, D., Cole, E., Baker, K.N., White, S.N., Donofrio, G., Li, H., Cunha, C.W. 2021. OvHV-2 glycoprotein B delivered by a recombinant BoHV-4 is immunogenic and induces partial protection against sheep-associated malignant catarrhal fever in a rabbit model. Vaccines. 9(2). Article 90. https://doi.org/10.3390/vaccines9020090.

Diphtheric aspergillosis tracheitis with gastrointestinal dissemination secondary to viral infections in a dairy calf - (Peer Reviewed Journal)
Headley, S.A., Muller, M.C., de Oliveira, T.E.S., Barros Gil Duarte, C.A., Valente Pereira, P.F., Vieira, M.V., Cunha, C.W., Flores, E.F., Lisboa, J.A.N., Pretto-Giordano, L.G. 2020. Diphtheric aspergillosis tracheitis with gastrointestinal dissemination secondary to viral infections in a dairy calf. Microbial Pathogenesis. 149. Article 104497. https://doi.org/10.1016/j.micpath.2020.104497.

A review of the epidemiological, clinical, and pathological aspects of malignant catarrhal fever in Brazil - (Review Article)
Headley, S.A., de Oliveira, T.E.S., Cunha, C.W. 2020. A review of the epidemiological, clinical, and pathological aspects of malignant catarrhal fever in Brazil. Brazilian Journal of Microbiology. 51:1405-1432. https://doi.org/10.1007/s42770-020-00273-6.

Ibex-associated malignant catarrhal fever in duikers (Cephalophus spp) - (Peer Reviewed Journal)
Carvallo, F.R., Uzal, F.A., Moore, J.D., Jackson, K., Nyaoke, A.C., Naples, L., Davis-Powell, J., Stadler, C.K., Boren, B.A., Cunha, C.W., Li, H., Pesavento, P.A. 2020. Ibex-associated malignant catarrhal fever in duikers (Cephalophus spp). Veterinary Pathology. 57(4):577-581. https://doi.org/10.1177/0300985820918313.

Immunohistochemical detection of intralesional antigens of Ovine gammaherpesvirus-2 in cattle with sheep-associated malignant catarrhal fever - (Peer Reviewed Journal)
Headley, S.A., Oliveria, T.E.S., Li, H., Lisbôa, J.A.N., Queiroz, G.R., Fritzen, J.T.T., Flores, E.F., Alfieri, A.A., Cunha, C.W. 2019. Immunohistochemical detection of intralesional antigens of Ovine gammaherpesvirus-2 in cattle with sheep-associated malignant catarrhal fever. Journal of Comparative Pathology. 174:86-98. https://doi.org/10.1016/j.jcpa.2019.11.002.

Domestic sheep and bighorn sheep carry distinct gammaherpesviruses belonging to the genus Macavirus - (Peer Reviewed Journal)
Cunha, C.W., Slater, O.M., Macbeth, B., Duignan, P.J., Warren, A., Highland, M.A., Li, H. 2019. Domestic sheep and bighorn sheep carry distinct gammaherpesviruses belonging to the genus Macavirus. Virus Research. 272. https://doi.org/10.1016/j.virusres.2019.197729.

A rabbit model for sheep-associated malignant catarrhal fever research: from virus infection to pathogenesis studies and vaccine development - (Peer Reviewed Journal)
Cunha, C.W., O'Toole, D., Taus, N.S., Shringi, S., Knowles, D.P., Li, H. 2019. A rabbit model for sheep-associated malignant catarrhal fever research: from virus infection to pathogenesis studies and vaccine development. Current Clinical Microbiology Reports. 6:148-155. https://doi.org/10.1007/s40588-019-00126-3.

Detection and genotypic characterization of toxoplasma gondii DNA within the milk of mongolian livestock - (Peer Reviewed Journal)
Iacobucci, E., Fritz, H., Papageorgiou, S., O'Conner, R., Taus, N.S., Ueti, M.W. 2019. Detection and genotypic characterization of toxoplasma gondii DNA within the milk of mongolian livestock. Parasitology Research. https://doi.org/10.1007/s00436-019-06306-w.

Silencing expression of the Rhipicephalus microplus vitellogenin receptor gene blocks Babesia bovis transmission and interferes with oocyte maturation - (Peer Reviewed Journal)
Hussein, H.E., Johnson, W.C., Taus, N.S., Suarez, C.E., Scoles, G.A., Ueti, M.W. 2019. Silencing expression of the Rhipicephalus microplus vitellogenin receptor gene blocks Babesia bovis transmission and interferes with oocyte maturation. Parasites & Vectors. https://doi.org/10.1186/s13071-018-3270-1.

First report of Anaplasma marginale infection in goats, Brazil - (Peer Reviewed Journal)
Dasilva, N.B., Ueti, M.W., Johnson, W.C., Mira, A., Schnittger, L., Valente, J.D., Vidotto, O., Masterson, H.E., Taus, N.S., Vieira, T.S. 2018. First report of Anaplasma marginale infection in goats, Brazil. PLOS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pone.0202140.

In situ hybridization for localization of ovine herpesvirus 2, the agent of sheep-associated malignant catarrhal fever, in formalin-fixed tissues - (Peer Reviewed Journal)
Pesavento, P., Cunha, C.W., Li, H., Jackson, K., O'Toole, D. 2018. In situ hybridization for localization of ovine herpesvirus 2, the agent of sheep-associated malignant catarrhal fever, in formalin-fixed tissues. Veterinary Pathology. 56(1):78-86. https://doi.org/10.1177/0300985818798085.

Systemic necrotizing vasculitis in sheep is associated with ovine herpesvirus 2 - (Peer Reviewed Journal)
Pesavento, P., Dange, R., Estrada, M., Dasjerdi, A., Pérez, V., Laroca, A., Silván, J., Diab, S., Jackson, K., Phillips, I., Li, H., Cunha, C.W., Wessels, M. 2018. Systemic necrotizing vasculitis in sheep is associated with ovine herpesvirus 2. Veterinary Pathology. 56:(1)87-92. https://doi.org/10.1177/0300985818795166.

Evaluation of glycoprotein Ov8 as a potential antigen for an OvHV-2-specific diagnostic assay - (Peer Reviewed Journal)
Alhajri, S.M., Cunha, C.W., Knowles, D.P., Li, H., Taus, N.S. 2018. Evaluation of glycoprotein Ov8 as a potential antigen for an OvHV-2-specific diagnostic assay. PLoS One. 13(7):30200130. https://doi.org/10.1371/journal.pone.0200130.

Malignant catarrhal fever - (Book / Chapter)
O'Toole, D., Li, H. 2018. Malignant catarrhal fever. In: Coetzer, J.A.W., Penrith, M.L., Maclachlan, N.J., Thomson, G.R., editors. Infectious Diseases of Livestock. Anipedia. Available: https://anipedia.org/resources/malignant-catarrahl-fever/1199.

Seroprevalence of malignant catarrhal fever virus in captive wildebeest (Connochaetes sp.) in France - (Peer Reviewed Journal)
Ortiz, K., Javaux, J., Simon, M., Petit, T., Clavel, S., Lamglait, B., Blanc, B., Brunet, A., Myster, F., Li, H., Dewals, B. 2018. Seroprevalence of malignant catarrhal fever virus in captive wildebeest (Connochaetes sp.) in France. Transboundary and Emerging Diseases. https://doi.org/10.1111/tbed.12929.

High copy number of ovine gammaherpesvirus 2 DNA associated with malignant catarrhal fever-like syndrome in a lamb - (Peer Reviewed Journal)
Phillips, I.L., Cunha, C.W., Galbraith, D., Highland, M.A., Bildfell, R.J., Li, H. 2018. High copy number of ovine gammaherpesvirus 2 DNA associated with malignant catarrhal fever-like syndrome in a lamb. Journal of Veterinary Diagnostic Investigation. https://doi.org/10.1177/1040638718766976.