Research Project: Characterization of Antigens, Virulence Markers, and Host Immunity in the Pathogenesis of Johne’s Disease

Location: Infectious Bacterial Diseases Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Exogenous vitamin D3 modulates response of bovine macrophages to Mycobacterium avium subsp. paratuberculosis infection and is dependent upon stage of Johne's disease - (Peer Reviewed Journal)
Wherry, T., Dassanayake, R.P., Casas, E., Mooyottu, S., Bannantine, J.P., Stabel, J.R. 2022. Exogenous vitamin D3 modulates response of bovine macrophages to Mycobacterium avium subsp. paratuberculosis infection and is dependent upon stage of Johne's disease. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2021.773938.

Use of a ferret model to test efficacy and immunogenicity of live attenuated Mycobacterium avium subspecies paratuberculosis vaccines - (Book / Chapter)
Bannantine, J.P., Gupta, T., Zinniel, D.K., Hikal, A., Quinn, F.D., Barletta, R.G. 2021. Use of a ferret model to test efficacy and immunogenicity of live attenuated Mycobacterium avium subspecies paratuberculosis vaccines. Methods in Molecular Biology. https://doi.org/10.1007/978-1-0716-1888-2_5.

A comparative study on the efficiency of two Mycobacterium avium subsp. paratuberculosis (MAP)-derived lipopeptides of L3P and L5P as capture antigens in an in-house milk ELISA test - (Peer Reviewed Journal)
Hosseiniporgham, S., Biet, F., Ganneau, C., Bannantine, J.P., Bay, S., Secche, L. 2021. A comparative study on the efficiency of two Mycobacterium avium subsp. paratuberculosis (MAP)-derived lipopeptides of L3P and L5P as capture antigens in an in-house milk ELISA test. Vaccines. 9(9). Article 997. https://doi.org/10.3390/vaccines9090997.

Draft genome sequences of two Bison-type and two Sheep-type strains of Mycobacterium avium subspecies paratuberculosis - (Peer Reviewed Journal)
Bannantine, J.P., Bayles, D.O. 2021. Draft genome sequences of two Bison-type and two Sheep-type strains of Mycobacterium avium subspecies paratuberculosis. Microbiology Resource Announcements. 10(28). Page 21. https://doi.org/10.1128/MRA.00526-21.

Comparative cellular immune responses in calves after infection with Mycobacterium avium subsp. paratuberculosis, M. avium subsp. avium, M. kansasii and M. bovis - (Peer Reviewed Journal)
Stabel, J.R., Waters, W.R., Bannantine, J.P., Palmer, M.V. 2021. Comparative cellular immune responses in calves after infection with Mycobacterium avium subsp. paratuberculosis, M. avium subsp. avium, M. kansasii and M. bovis. Veterinary Immunology and Immunopathology. 237. https://doi.org/10.1016/j.vetimm.2021.110268.

Comparison of a mycobacterial phage assay to detect viable Mycobacterium avium subspecies paratuberculosis with standard diagnostic modalities in cattle with naturally infected Johne disease - (Peer Reviewed Journal)
Greenstein, R.J., Su, L., Grant, I.R., Foddai, A.C., Turner, A.M., Nagati, J.S., Brown, S.T., Stabel, J.R. 2021. Comparison of a mycobacterial phage assay to detect viable Mycobacterium avium subspecies paratuberculosis with standard diagnostic modalities in cattle with naturally infected Johne disease. Gut Pathogens. https://doi.org/10.1186/s13099-021-00425-5.

Reduced tissue colonization of Mycobacterium avium subsp. paratuberculosis in neonatal calves vaccinated with a cocktail of recombinant proteins - (Peer Reviewed Journal)
Stabel, J.R., Bannantine, J.P. 2021. Reduced tissue colonization of Mycobacterium avium subsp. paratuberculosis in neonatal calves vaccinated with a cocktail of recombinant proteins. Vaccine. https://doi.org/10.1016/j.vaccine.2021.04.051.

Prediction of Johne's disease state based upon quantification of T cell markers and their interaction with macrophages in the bovine intestine - (Peer Reviewed Journal)
Jenvey, C.J., Shircliff, A.L., Obando Marrero, E.E., Stabel, J.R. 2021. Prediction of Johne's disease state based upon quantification of T cell markers and their interaction with macrophages in the bovine intestine. Veterinary Research. Vol 52 Article 55. https://doi.org/10.1186/s13567-021-00925-x.

Whole-genome analysis of Mycobacterium avium subsp. paratuberculosis IS900 insertions reveals strain type-specific modalities - (Peer Reviewed Journal)
Conde, C., Price-Carter, M.L., Cochard, T., Branger, M., Stevenson, K., Whittington, R., Bannantine, J.P., Biet, F. 2021. Whole-genome analysis of Mycobacterium avium subsp. paratuberculosis IS900 insertions reveals strain type-specific modalities. Frontiers in Microbiology. Vol. 12, Article 660002. https://doi.org/10.3389/fmicb.2021.660002.

Engineering synthetic lipopeptide antigen for specific detection of Mycobacterium avium subsp. paratuberculosis infection - (Peer Reviewed Journal)
Bay, S., Begg, D., Ganneau, C., Branger, M., Cochard, T., Bannantine, J.P., Kohler, H., Moyen, J., Whittington, R.J., Biet, F. 2021. Engineering synthetic lipopeptide antigen for specific detection of Mycobacterium avium subsp. paratuberculosis infection. Frontiers in Veterinary Science. 8. https://doi.org/10.3389/fvets.2021.637841.

Prediction of Johne's disease state based upon quantification of T cell markers and their interaction with macrophages in the bovine intestine - (Peer Reviewed Journal)
Jenvey, C.J., Shircliff, A.L., Obando Marrero, E.E., Stabel, J.R. 2021. Prediction of Johne's disease state based upon quantification of T cell markers and their interaction with macrophages in the bovine intestine. Veterinary Research. https://doi.org/10.1186/s13567-021-00925-x.

Complete genome sequence of a type III ovine strain of Mycobacterium avium subspecies paratuberculosis - (Peer Reviewed Journal)
Bannantine, J.P., Bayles, D.O., Biet, F. 2021. Complete genome sequence of a type III ovine strain of Mycobacterium avium subspecies paratuberculosis. Microbiology Resource Announcements. 10. https://doi.org/10.1128/MRA.01480-20.

Electrochemical detection of serum antibodies against Mycobacterium avium subspecies paratuberculosis - (Peer Reviewed Journal)
Hatate, K., Rice, J., Parker, K., Wu, J., Turner, A.M., Stabel, J.R., Eda, S. 2021. Electrochemical detection of serum antibodies against Mycobacterium avium subspecies paratuberculosis. Frontiers in Veterinary Science. 8. https://doi.org/10.3389/fvets.2021.642833.

Diagnostic sequences that distinguish M. avium subspecies strains - (Peer Reviewed Journal)
Bannantine, J.P., Stabel, J.R., Bayles, D.O., Condes, C., Biet, F. 2021. Diagnostic sequences that distinguish M. avium subspecies strains. Frontiers in Veterinary Science. 7. https://doi.org/10.3389/fvets.2020.620094.

Diseases of dairy animals: infectious diseases: Johne's disease - (Book / Chapter)
Stabel, J.R., Collins, M.T. 2020. Diseases of dairy animals: infectious diseases: Johne's disease. Book Chapter. (3)786-792. https://doi.org/10.1016/B0-12-227235-8/00219-4.

An eco-friendly decontaminant to kill Mycobacterium avium subsp. paratuberculosis - (Peer Reviewed Journal)
Stabel, J.R., Turner, A.M., Walker, M.E. 2020. An eco-friendly decontaminant to kill Mycobacterium avium subsp. paratuberculosis. Journal of Microbiological Methods. 176. https://doi.org/10.1016/j.mimet.2020.106001.

Genetic diversity among Mycobacterium avium subspecies revealed by analysis of complete genome sequences - (Peer Reviewed Journal)
Bannantine, J.P., Conde, C., Bayles, D.O., Branger, M., Biet, F. 2020. Genetic diversity among Mycobacterium avium subspecies revealed by analysis of complete genome sequences. Frontiers in Microbiology. 11. https://doi.org/10.3389/fmicb.2020.01701.

Comparison of sheep, goats, and calves as infection models for Mycobacterium avium subsp. paratuberculosis - (Peer Reviewed Journal)
Stabel, J.R., Bannantine, J.P., Hoestetter, J.M. 2020. Comparison of sheep, goats, and calves as infection models for Mycobacterium avium subsp. paratuberculosis. Veterinary Immunology and Immunopathology. 225(110060). https://doi.org/10.1016/j.vetimm.2020.110060.

Elucidating the regulon of a fur-like protein in Mycobacterium avium subsp. paratuberculosis (MAP) - (Peer Reviewed Journal)
Shoyama, F.M., Janetanakit, T., Bannantine, J.P., Barletta, R., Sreevatsan, S. 2020. Elucidating the regulon of a fur-like protein in Mycobacterium avium subsp. paratuberculosis (MAP). Frontiers in Microbiology. 11:598. https://doi.org/10.3389/fmicb.2020.00598.

Identification of sero-diagnostic antigens for the early diagnosis of Johne's disease using MAP protein microarrays - (Peer Reviewed Journal)
Li, L., Bannantine, J.P., Campo, J.J., Randall, A., Grohn, Y.T., Schilling, M., Katani, R., Radzio-Basu, J., Easterling, L., Kapur, V. 2019. Identification of sero-diagnostic antigens for the early diagnosis of Johne's disease using MAP protein microarrays. Scientific Reports. 9:17573. https://doi.org/10.1038/s41598-019-53973-x.

Characterization of ethanol extracted cell wall components of Mycobacterium avium subsp. paratuberculosis - (Peer Reviewed Journal)
Bannantine, J.P., Wadhwa, A., Stabel, J.R., Eda, S. 2019. Characterization of ethanol extracted cell wall components of Mycobacterium avium subsp. paratuberculosis. Veterinary Sciences. 6(4):88. https://doi.org/10.3390/vetsci6040088.

Divergent antigen-specific cellular immune responses during asymptomatic subclinical and clinical states of disease in cows naturally infected with Mycobacterium avium subsp. paratuberculosis - (Peer Reviewed Journal)
Stabel, J.R., Bannantine, J.P. 2019. Divergent antigen-specific cellular immune responses during asymptomatic subclinical and clinical states of disease in cows naturally infected with Mycobacterium avium subsp. paratuberculosis. Infection and Immunity. 88(1):e00650-19. https://doi.org/10.1128/IAI.00650-19.

Phenotypes of macrophages present in the intestine are impacted by stage of diseae in cattle naturally infected with Mycobacterium avium subsp. paratuberculosis - (Peer Reviewed Journal)
Jenvey, C.J., Shircliff, A.L., Bannantine, J.P., Stabel, J.R. 2019. Phenotypes of macrophages present in the intestine are impacted by stage of disease in cattle naturally infected with Mycobacterium avium subsp. paratuberculosis. PLoS One. 14(5). https://doi.org/10.1371/journal.pone.0217649.

A peptide-based vaccine for Mycobacterium avium subspecies paratuberculosis - (Peer Reviewed Journal)
Abdellrazeq, G.S., Elnaggar, M.M., Bannantine, J.P., Schneider, D.A., Souza, C.D., Hwang, J., Mahmoud, A.H., Hulubei, V., Fry, L.M., Park, K., Davis, W.C. 2019. A peptide-based vaccine for Mycobacterium avium subspecies paratuberculosis. Vaccine. 37(21):2783-2790. https://doi.org/10.1016/j.vaccine.2019.04.040.

Transposon mutagenesis in Mycobacterium avium subspecies paratuberculosis - (Peer Reviewed Journal)
Bannantine, J.P., Zinniel, D., Barletta, R.G. 2019. Transposon mutagenesis in Mycobacterium avium subspecies paratuberculosis. Methods in Molecular Biology. 2016/117-125. https://doi.org/10.1007/978-1-4939-9570-7_11.

Quantification of macrophages and Mycobacterium avium subsp. paratuberculosis in bovine intestinal tissue during different stages of Johne's disease. - (Peer Reviewed Journal)
Jenvey, C.J., Hostetter, J.M., Shircliff, A.L., Bannantine, J.P., Stabel, J.R. 2019. Quantification of macrophages and Mycobacterium avium subsp. paratuberculosis in bovine intestinal tissue during different stages of Johne's disease. Veterinary Pathology. https://doi.org/10.1177/0300985819844823.

Membrane and cytoplasmic proteins of Mycobacterium avium subspecies paratuberculosis that bind to novel monoclonal antibodies - (Peer Reviewed Journal)
Bannantine, J.P., Stabel, J.R., Lippolis, J.D., Reinhardt, T.A. 2018. Membrane and cytoplasmic proteins of Mycobacterium avium subspecies paratuberculosis that bind to novel monoclonal antibodies. Microorganisms. 6(4):127. https://doi.org/10.3390/microorganisms6040127.

Vitamin D status and responses in dairy cows naturally infected with Mycobacterium avium subsp. paratuberculosis - (Peer Reviewed Journal)
Stabel, J.R., Reinhardt, T.A., Hempel, R.J. 2018. Vitamin D status and responses in dairy cows naturally infected with Mycobacterium avium subsp. paratuberculosis. Journal of Dairy Science. 102(2):1594-1600. https://doi.org/10.3168/jds.2018-15241.

Effects of vitamin D3 on macrophages from cows naturally infected with Mycobacterium avium subsp. paratuberculosis - (Abstract Only)

In-vitro characterization of Mycobacterium avium subsp. paratuberculosis attenuated mutants with DIVA potential - (Abstract Only)

Failure to detect M. avium subspecies paratuberculosis in Johne’s disease using a proprietary fluorescent in situ hybridization assay - (Peer Reviewed Journal)
Greenstein, R.J., Su, L., Fam, P.S., Stabel, J.R., Brown, S.T. 2018. Failure to detect M. avium subspecies paratuberculosis in Johne’s disease using a proprietary fluorescent in situ hybridization assay. BMC Research Notes. 11:498. https://doi.org/10.1186/s13104-018-3601-5.

Relationship between the pathology of bovine intestinal tissue and current diagnostic tests for Johne's disease - (Peer Reviewed Journal)
Jenvey, C.J., Hostetter, J.M., Shircliff, A.L., Bannantine, J.P., Stabel, J.R. 2018. Relationship between the pathology of bovine intestinal tissue and current diagnostic tests for Johne's disease. Veterinary Immunology and Immunopathology. 202:93-101. https://doi.org/10.1016/j.vetimm.2018.06.012.

Evaluating the cytokine profile of the WC1+ gamma delta T cell subset in the ileum of cattle with the subclinical and clinical forms of MAP infection - (Peer Reviewed Journal)
Albarrak, S.M., Waters, W.R., Stabel, J.R., Hostetter, J.M. 2018. Evaluating the cytokine profile of the WC1+ gamma delta T cell subset in the ileum of cattle with the subclinical and clinical forms of MAP infection. Veterinary Immunology and Immunopathology. 201:26-31. https://doi.org/10.1016/j.vetimm.2018.05.003.

Application of the biosafety RAM and eProtocol software programs to streamline institutional biosafety committee processes at the USDA-National Animal Disease Center - (Peer Reviewed Journal)
Bannantine, J.P., Register, K.B., White, D.M. 2018. Application of the biosafety RAM and eProtocol software programs to streamline institutional biosafety committee processes at the USDA-National Animal Disease Center. Applied Biosafety. 10.1177/1535676018767904.

Effect of feeding heat-treated colostrum on cell-mediated immune response to Mycobacterium avium subsp. paratuberculosis in neonatal dairy calves - (Abstract Only)
Shoyama, F.M., Taya, J.L., Wells, S.J., Stabel, J.R., Cheeran, M.C., Sreevatsan, S., Godden, S.M. 2018. Effect of feeding heat-treated colostrum on cell-mediated immune response to Mycobacterium avium subsp. paratuberculosis in neonatal dairy calves. Meeting Abstract. 113/58.

Failure to detect M. avium subspecies paratuberculosis by fluorescent in situ hybridization (FISH) in Johne’s or Crohn’s disease using a proprietary assay - (Abstract Only)
Greenstein, R.J., Su, L., Fam, P., Stabel, J.R., Brown, S.T. 2018. Failure to detect M. avium subspecies paratuberculosis by fluorescent in situ hybridization (FISH) in Johne’s or Crohn’s disease using a proprietary assay. Meeting Abstract. 1.2/16.

Comparison of sheep, goats, and calves as infection models for Mycobacterium avium subsp. paratuberculosis - (Abstract Only)

Disease state influences the presence of macrophages and Mycobacterium avium subsp. paratuberculosis in bovine intestinal tissue - (Abstract Only)

Environmental Mycobacterium avium subsp. paratuberculosis hosted by free-living amoebae - (Peer Reviewed Journal)
Samba-Louaka, A., Robino, E., Cochard, T., Branger, M., Delafont, V., Aucher, W., Wambeke, W., Bannantine, J.P., Biet, F., Hechard, Y. 2018. Environmental Mycobacterium avium subsp. paratuberculosis hosted by free-living amoebae. Frontiers in Cellular and Infection Microbiology. 8:28. https://doi.org/10.3389/fcimb.2018.00028.

Pathogenesis, molecular genetics, and genomics of Mycobacterium avium subsp. paratuberculosis, the etiologic agent of Johne’s disease - (Peer Reviewed Journal)
Rathnaiah, G., Zinniel, D., Bannantine, J.P., Stabel, J.R., Grohn, Y.T., Collins, M.T., Barletta, R.G. 2017. Pathogenesis, molecular genetics, and genomics of Mycobacterium avium subsp. paratuberculosis, the etiologic agent of Johne’s disease. Frontiers in Veterinary Science. 4:187. https://doi.org/10.3389/fvets.2017.00187.

Molecular genetic analysis of a large Mycobacterium avium subsp. paratuberculosis mutant bank - (Abstract Only)
Rathnaiah, G., Bayles, D.O., Stabel, J.R., Zinniel, D., Bannantine, J.P., Grohn, Y.T., Barletta, R.G. 2017. Molecular genetic analysis of a large Mycobacterium avium subsp. paratuberculosis mutant bank. Meeting Abstract. P010/144.

Disease state influences the presence of macrophages and Mycobacterium avium subsp. paratuberculosis in bovine intestinal tissue - (Abstract Only)
Jenvey, C.J., Hostetter, J.M., Bannantine, J.P., Stabel, J.R. 2017. Disease state influences the presence of macrophages and Mycobacterium avium subsp. paratuberculosis in bovine intestinal tissue. Meeting Abstract. 193/109.

Relationship between the pathology of bovine intestinal tissue and current diagnostic tests for Johne's disease - (Abstract Only)
Jenvey, C.J., Hostetter, J.M., Stabel, J.R. 2017. Relationship between the pathology of bovine intestinal tissue and current diagnostic tests for Johne's disease. Meeting Abstract. 194/109.

Sudan Black B masks Mycobacterium avium subspecies paratuberculosis immunofluorescent antibody labeling - (Peer Reviewed Journal)
Stabel, J.R., Jenvey, C.J. 2017. Sudan Black B masks Mycobacterium avium subspecies paratuberculosis immunofluorescent antibody labeling. Histology and Histopathy. 4(11). doi:10.7243/2055-091X-4-11.

Identification of sero-reactive antigens for the early diagnosis of Johne's disease in cattle - (Peer Reviewed Journal)
Li, L., Bannantine, J.P., Campo, J.J., Randall, A., Grohn, Y.T., Katani, R., Schilling, M., Radzio-Basu, J., Kapur, V. 2017. Identification of sero-reactive antigens for the early diagnosis of Johne's disease in cattle. PLoS One. 12(9). https://doi.org/10.1371/journal.pone.0184373.

Autofluorescence and non-specific immunofluorescent labeling in frozen bovine intestinal tissue sections: Solutions for multi-color immunofluorescence experiments - (Peer Reviewed Journal)
Stabel, J.R., Jenvey, C.J. 2017. Autofluorescence and non-specific immunofluorescent labeling in frozen bovine intestinal tissue sections: Solutions for multi-color immunofluorescence experiments. Journal of Histochemistry and Cytochemistry. 65(9):531-541. https://doi.org/10.1369/0022155417724425.

Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection - (Peer Reviewed Journal)
Barkema, H.W., Orsel, K., Nielsen, S.S., Koets, A.P., Rutten, V.P., Bannantine, J.P., Keefe, G.P., Kelton, D.F., Wells, S.J., Whittington, R.J., Mackintosh, C.G., Manning, E.J., Weber, M.F., Heuer, C., Forde, T., Ritter, C., Roche, S., Corbett, C., Wolf, R., Kastelic, J.P., De Buck, J. 2017. Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection. Transboundary and Emerging Diseases. 65(Suppl. 1) 125-148. https://doi.org/10.1111/tbed.12723.

Identification of novel seroreactive antigens in Johne’s disease cattle using the Mycobacterium tuberculosis protein array - (Peer Reviewed Journal)
Bannantine, J.P., Campo, J., Randall, A., Pablo, J., Praul, C.A., Raygoza Garay, J.A., Li, L., Stabel, J.R., Kapur, V. 2017. Identification of novel seroreactive antigens in Johne’s disease cattle using the Mycobacterium tuberculosis protein array. Clinical and Vaccine Immunology. 24(7). https://doi.org/10.1128.CVI.00081-17.