Research Project: Characterize the Immunopathogenesis and Develop Diagnostic and Mitigation Strategies to Control Tuberculosis in Cattle and Wildlife

Location: Infectious Bacterial Diseases Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Potential for improved detection of bovine tuberculosis by targeting combined blood biomarkers in multi-test algorithms - (Peer Reviewed Journal)
Sridhara, A.A., Johnathan-Lee, A., Elahi, R., Sikar-Gang, A., Lambotte, P., Esfandiari, J., De Juan, L., Gortazar, C., Jones, G., Vordermeier, H., Marpe, B.N., Thacker, T.C., Palmer, M.V., Waters, W., Lyachchenko, K.P. 2022. Potential for improved detection of bovine tuberculosis by targeting combined blood biomarkers in multi-test algorithms. Veterinary Immunology and Immunopathology. Volume 248, June 2022, 110419. https://doi.org/10.1016/j.vetimm.2022.110419.

Bovine tuberculosis: a disease at the interface of cattle, wildlife and humans - (Book / Chapter)
Palmer, M.V., Boggiatto, P.M., Kanipe, C., Lombard, J. 2023. Bovine tuberculosis: a disease at the interface of cattle, wildlife and humans. Book Chapter. 11(p 829-846). https://doi.org/10.1007/978-3-031-15955-8.

Research on a TB vaccine for use in free-ranging white-tailed deer - (Abstract Only)

Novel polyprotein antigens designed for improved serodiagnosis of bovine tuberculosis - (Peer Reviewed Journal)
Lyashchenko, K.P., Sikar-Gang, A., Sridhara, A.A., Johnathan-Lee, A., Lambotte, P., Esfandiari, J., Ireton, G.C., Duthie, M., Reed, S.G., Jones, G., Vordermeier, M.H., Thacker, T.C., Palmer, M.V., Waters, W.R. 2021. Novel polyprotein antigens designed for improved serodiagnosis of bovine tuberculosis. Frontiers in Veterinary Science. 240. Article 110320. https://doi.org/10.1016/j.vetimm.2021.110320.

Use of blood matrices and alternative biological fluids for antibody detection in animal tuberculosis - (Peer Reviewed Journal)
Lyaschcenko, K., Sikar-Gang, A., Sridhara, A., Johnathan-Lee, A., Elahi, R., Greenwald, R., Lambotte, P., Esfandiari, J., Roos, E., Kerry, T., Miller, M., Thacker, T.C., Palmer, M.V., Waters, W.R. 2021. Use of blood matrices and alternative biological fluids for antibody detection in animal tuberculosis. Veterinary Immunology and Immunopathology. 239. Article 110303. https://doi.org/10.1016/j.vetimm.2021.110303.

Enhanced detection of Mycobacterium bovis-specific T cells in experimentally-infected cattle - (Peer Reviewed Journal)
Boggiatto, P.M., Kanipe, C.R., Palmer, M.V. 2021. Enhanced detection of Mycobacterium bovis-specific T cells in experimentally-infected cattle. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2021.676710.

Heterogeneity of pulmonary granulomas in cattle experimentally infected with Mycobacterium bovis - (Peer Reviewed Journal)
Palmer, M.V., Thacker, T.C., Kanipe, C.R., Boggiatto, P.M. 2021. Heterogeneity of pulmonary granulomas in cattle experimentally infected with Mycobacterium bovis. Frontiers in Veterinary Science. 8. https://doi.org/10.3389/fvets.2021.671460.

Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2 - (Abstract Only)
Palmer, M.V., Martins, M., Falkenberg, S.M., Devries, A.C., Caserta, L.D., Mitchell, P.K., Wagner, B., Cassmann, E.D., Lager, K.M., Diel, D.G. 2021. Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2. Virtual. 86th North American Wildlife and Natural Resources Conference.

Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2 - (Peer Reviewed Journal)
Palmer, M.V., Martins, M., Falkenberg, S.M., Buckley, A.C., Caserta, L.D., Mitchell, P.K., Wagner, B., Cassmann, E.D., Lager, K.M., Diel, D.G. 2021. Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2. Journal of Virology. 95(11). Article e0008321. https://doi.org/10.1128/JVI.00083-21.

Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2 - (Abstract Only)
Palmer, M.V., Martins, M., Falkenberg, S.M., Devries, A.C., Caserta, L.D., Mitchell, P.K., Wagner, B., Cassmann, E.D., Lager, K.M., Diel, D.G. 2020. Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2. Virtual Symposium. December 1-3, 2020.

Mycobacterium bovis and you: a comprehensive look at the bacteria, its similarities to Mycobacterium tuberculosis, and its relationship with human disease - (Literature Review)
Kanipe, C., Palmer, M.V. 2020. Mycobacterium bovis and you: a comprehensive look at the bacteria, its similarities to Mycobacterium tuberculosis, and its relationship with human disease. Tuberculosis. 125. https://doi.org/10.1016/j.tube.2020.102006.

Severity of bovine tuberculosis is associated with innate immune-biased transcriptional signatures of whole blood in early weeks after experimental Mycobacterium bovis infection - (Peer Reviewed Journal)
Wiarda, J.E., Boggiatto, P.M., Bayles, D.O., Waters, R.W., Thacker, T.C., Palmer, M.V. 2020. Severity of bovine tuberculosis is associated with innate immune-biased transcriptional signatures of whole blood in early weeks after experimental Mycobacterium bovis infection. PLoS ONE. 15(11). https://doi.org/10.1371/journal.pone.0239938.

Memory B cells and tuberculosis - (Literature Review)
Lyashchenko, K.P., Vordermeier, H., Waters, W.R. 2020. Memory B cells and tuberculosis. Veterinary Immunology and Immunopathology. 221(110016). https://doi.org/10.1016/j.vetimm.2020.110016.

Evaluation of A baculovirus-expressed VP2 subunit vaccine for the protection of white-tailed deer (Odocoileus virginianus) from epizootic hemorrhagic disease - (Abstract Only)

Differential antigen recognition by serum antibodies from three bovid hosts of Mycobacterium bovis infection - (Peer Reviewed Journal)
Lyashchenko, K.P., Sridhara, A.A., Johnathan-Lee, A., Sikar-Gang, A., Lambotte, P., Esfandiari, J., Bernitz, N., Kerr, T.J., Miller, M.A., Waters, R.W. 2020. Differential antigen recognition by serum antibodies from three bovid hosts of Mycobacterium bovis infection. Comparative Immunology Microbiology and Infectious Diseases. 69(101424). https://doi.org/10.1016/j.cimid.2020.101424.

Mycobacterium bovis bacille Calmette-Guérin (BCG) results in positive tuberculin skin test results in a dose-dependent fashion in white-tailed deer (Odocoileus virginianus) - (Peer Reviewed Journal)
Palmer, M.V., Waters, W.R., Thacker, T.C. 2020. Vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis bacille Calmette-Guérin (BCG) results in positive tuberculin skin test results in a dose-dependent fashion. Research in Veterinary Science. 129:70-73. https://doi.org/10.1016/j.rvsc.2020.01.010.

Biomarkers of cell-mediated immunity to bovine tuberculosis - (Peer Reviewed Journal)

Characteristics of subclinical Mycobacterium avium subsp paratuberculosis infection in a captive white-tailed deer herd - (Peer Reviewed Journal)
Palmer, M.V., Kanipe, C., Cox, R.J., Robbe Austerman, S., Thacker, T.C. 2019. Characteristics of subclinical Mycobacterium avium ssp. paratuberculosis infection in a captive white-tailed deer herd. Journal of Veterinary Diagnostic Investigation. 31(6):844-851. https://doi.org/10.1177/1040638719873028.

Characterization of gamma delta T cell effector/memory subsets based on CD27 and CD45R expression in response to Mycobacterium bovis infection - (Peer Reviewed Journal)
Guerra-Maupome, M., Palmer, M.V., Waters, W.R., Mcgill, J.L. 2019. Characterization of gamma delta T cell effector/memory subsets based on CD27 and CD45R expression in response to Mycobacterium bovis infection. ImmunoHorizons. 3(6):208-218. https://doi.org/10.4049/immunohorizons.1900032.

Research with agricultural animals and wildlife - (Peer Reviewed Journal)
Cox, R.J., Nol, P., Ellis, C.K., Palmer, M.V. 2019. Research with agricultural animals and wildlife. ILAR Journal. https://doi.org/10.1093/ilar/ilz006.

Fatal tuberculosis in a free-ranging African elephant and one health implications of human pathogens in wildlife - (Peer Reviewed Journal)
Miller, M., Buss, P., Roos, E., Hausler, G., Dippenaar, A., Mitchell, E., Van Schalkwyk, L., Robbe Austerman, S., Waters, W.R., Sikar-Gang, A., Lyashchenko, K., Parsons, S.D., Warren, R., Van Helden, P. 2019. Fatal tuberculosis in a free-ranging African elephant and one health implications of human pathogens in wildlife. Frontiers in Veterinary Science. 6, article 18: 1-8. https://doi.org/10.3389/fvets.2019.00018.

Early pulmonary lesions in cattle infected via aerosolized Mycobacterium bovis - (Peer Reviewed Journal)
Palmer, M.V., Wiarda, J.E., Kanipe, C., Thacker, T.C. 2019. Early pulmonary lesions in cattle infected via aerosolized Mycobacterium bovis. Veterinary Pathology. 56(4). https://doi.org/10.1177%2F0300985819833454.

Use of the human vaccine, Mycobacterium bovis Bacillus Calmette Guerin in deer - (Peer Reviewed Journal)
Palmer, M.V., Thacker, T.C. 2018. Use of the human vaccine, Mycobacterium bovis Bacillus Calmette Guerin in deer. Frontiers in Veterinary Science. 5:244. https://doi.org/10.3389/fvets.2018.00244.

Measuring bovine gamma delta T cell function at the site of Mycobacterium bovis infection - (Peer Reviewed Journal)
Rusk, R.A., Palmer, M.V., Waters, W.R., McGill, J.L. 2017. Measuring bovine gamma delta T cell function at the site of Mycobacterium bovis infection. Veterinary Immunology and Immunopathology. 193-194:38-49. https://doi.org/10.1016/j.vetimm.2017.10.004.

Pathology of the emerging Mycobacterium tuberculosis complex pathogen, Mycobacterium mungi, in the banded mongoose (Mungos mungo) - (Peer Reviewed Journal)
Alexander, K.A., Laver, P.N., Williams, M.C., Sanderson, C.E., Kanipe, C., Palmer, M.V. 2017. Pathology of the emerging Mycobacterium tuberculosis complex pathogen, Mycobacterium mungi, in the banded mongoose (Mungos mungo). Veterinary Pathology. 55(2):303-309. doi:10.1177/0300985817741730.

Evaluation of tissue fixation methods to inactivate Mycobacterium bovis under routine laboratory conditions - (Peer Reviewed Journal)
Thacker, T.C., Palmer, M.V., Waters, W.R. 2017. Evaluation of tissue fixation methods to inactivate Mycobacterium bovis under routine laboratory conditions. Applied Biosafety. 22(4):152-155. https://doi.org/10.1177%2F1535676017737315.

Immunology of bovine tuberculosis: Perspectives on one health approaches and defining correlates of protection versus infection - (Abstract Only)

Genome sequences of Escherichia coli strains that cause persistent and transient mastitis - (Peer Reviewed Journal)
Thacker, T.C., Lippolis, J.D., Brunelle, B.W., Casey, T., Reinhardt, T.A., Sacco, R.E., Holman, D.B. 2017. Genome sequences of Escherichia coli strains that cause persistent and transient mastitis. Genome Announcements. 5(34):e00775-17. https://doi.org/10.1128/genomeA.00775-17.

Emerging understanding of tuberculosis and the granuloma by comparative analysis in humans, cattle, zebrafish and non-human primates - (Review Article)
Palmer, M.V. 2018. Emerging understanding of tuberculosis and the granuloma by comparative analysis in humans, cattle, zebrafish and non-human primates. Veterinary Pathology. 55(1):8-10. https://doi.org/10.1177/0300985817712795.

Bovine tuberculosis - (Book / Chapter)

Detection of lipomannan in cattle infected with bovine tuberculosis - (Peer Reviewed Journal)
Vu, D.M., Sakamuri, R.M., Waters, W.R., Swanson, B.I., Mukundan, H. 2017. Detection of lipomannan in cattle infected with bovine tuberculosis. Analytical Sciences. 33(4):457-460. doi: 10.2116/analsci.33.457.