Research Project: Advanced Technology for Rapid Comprehensive Analysis of the Chemical Components

Location: Methods and Application of Food Composition Laboratory

Publications (Clicking on the reprint icon will take you to the publication reprint.)

A targeted and an untargeted metabolomics approach to study the phytochemicals of tomato cultivars grown under different salinity conditions - (Peer Reviewed Journal)
Tareq, F.S., Singh, J., Ferreira, J.F., Sandhu, D., Suarez, D.L., Luthria, D.L. 2024. A targeted and an untargeted metabolomics approach to study the phytochemicals of tomato cultivars grown under different salinity conditions. Journal of Agricultural and Food Chemistry. 72 7694-7706. https://doi.org/10.1021/acs.jafc.3c08498.

Fast and simple solid phase extraction-based method for glucosinolate determination: an alternative to ISO-9167 method - (Peer Reviewed Journal)
Li, Y., Zhang, M., Pehrsson, P.R., Harnly, J.M., Chen, P., Sun, J. 2024. Fast and simple solid phase extraction-based method for glucosinolate determination: an alternative to ISO-9167 method. Foods. 13, 650. https://doi.org/10.3390/foods13050650.

Study of uv-vis molar absorptivity variation and quantitation of anthocyanins using molar relative response factor - (Peer Reviewed Journal)
Dong, W., Yang, X., Chen, P., Sun, J., Harnly, J.M., Zhang, M., Zhang, N. 2024. Study of uv-vis molar absorptivity variation and quantitation of anthocyanins using molar relative response factor. Food Chemistry. 444-138653. https://doi.org/10.1016/j.foodchem.2024.138653.

Variability and determinants of secondary metabolite profiles in cranberries (Vaccinium macrocarpon) from key cultivation states - (Peer Reviewed Journal)
Geng, P., Harnly, J.M., Sun, J., Chen, P. 2024. Variability and determinants of secondary metabolite profiles in cranberries (Vaccinium macrocarpon) from key cultivation states. Journal of Agriculture and Food Research. 2666-1543. https://doi.org/10.1016/j.jafr.2024.100983.

Variation in botanical reference materials: similarity of actaea racemosa analyzed by flow injection mass spectrometry - (Peer Reviewed Journal)
Harnly, J.M., Upton, R. 2023. Variation in botanical reference materials: similarity of actaea racemosa analyzed by flow injection mass spectrometry. Journal of AOAC International. 107(2): 332–344. https://doi.org/10.1093/jaoacint/qsad137.

Partial three-dimensional chromatography of pulse triacylglycerols with triple parallel mass spectrometry - (Peer Reviewed Journal)
Byrdwell, W.C., Kotapati, H.K. 2023. Partial three-dimensional chromatography of pulse triacylglycerols with triple parallel mass spectrometry. Separations. 10: 594. https://doi.org/10.3390/separations10120594.

Modeling climate-based variability in the fatty acid composition of soybean oil in the American diet - (Peer Reviewed Journal)
Bukowski, M.R., Goslee, S.C. 2023. Modeling climate-based variability in the fatty acid composition of soybean oil in the American diet. Nature Climate Change. 119:1. https://doi.org/10.1016/j.ajcnut.2023.08.024.

Improved metabolomic approach for evaluation of phytochemicals in mustard, kale, and broccoli microgreens under different controlled environmental agriculture conditions - (Peer Reviewed Journal)
Li, Y., Zhou, B., Teng, Z., Zhang, M., Yu, L., Luo, Y., Chen, P., Sun, J. 2023. Improved metabolomic approach for evaluation of phytochemicals in mustard, kale, and broccoli microgreens under different controlled environmental agriculture conditions. Journal of Agriculture and Food Research. 14: 100719. https://doi.org/10.1016/j.jafr.2023.100719.

An untargeted metabolomics approach to study the variation between wild and cultivated soybeans - (Peer Reviewed Journal)
Tareq, F.S., Kotha, R.R., Natarajan, S.S., Sun, J., Luthria, D.L. 2023. An untargeted metabolomics approach to study the variation between wild and cultivated soybeans. Molecules. 28: 5507. https://doi.org/10.3390/molecules28145507.

Botanical authentication using one-class modeling - (Peer Reviewed Journal)
Harnly, J.M. 2023. Botanical authentication using one-class modeling. Journal of AOAC International. 106(4)1077–1086. https://doi.org/10.1093/jaoacint/qsad023.

Comprehensive oligosaccharide profiling of commercial almond milk, soy milk, and soy flour - (Peer Reviewed Journal)
Huang, Y., Bruna, P., Fukagawa, N.K., Barile, D. 2022. Comprehensive oligosaccharide profiling of commercial almond milk, soy milk, and soy flour. Food Chemistry. 409:135267. https://doi.org/10.1016/j.foodchem.2022.135267.

Quantitative bottom-up glycomic analysis of polysaccharides in food matrices using liquid chromatography – tandem mass spectrometry - (Peer Reviewed Journal)
Bacalzo, N., Couture, G., Ye, C., Castillo, J., Phillips, K., Fukagawa, N.K., Lebrilla, C. 2022. Quantitative bottom-up glycomic analysis of polysaccharides in food matrices using liquid chromatography – tandem mass spectrometry. Analytical Chemistry. 95:1008. https://doi.org/10.1021/acs.analchem.2c03707.

Oxidative Stress and Antioxidants - A Critical Review on in-vitro Antioxidant Assays - (Literature Review)
Kotha, R.R., Tareq, F.S., Yildiz, E., Luthria, D.L. 2022. Oxidative Stress and Antioxidants - A Critical Review on in-vitro Antioxidant Assays. Molecules. 11:2388. https://doi.org/10.3390/antiox11122388.

Fast Chromatography of Pulse Triacylglycerols - (Peer Reviewed Journal)
Byrdwell, W.C., Kotapati, H.K., Goldschmidt, R.J. 2022. Fast Chromatography of Pulse Triacylglycerols. Journal of the American Oil Chemists' Society. 100:25-43. https://doi.org/10.1002/aocs.12665.

Three-dimensional liquid chromatography with parallel second dimensions and quadruple parallel mass spectrometry for infant formula - (Peer Reviewed Journal)
Byrdwell, W.C., Hari, K.K., Goldschmidt, R.J., Jakubec, P., Novakova, L. 2022. Three-dimensional liquid chromatography with parallel second dimensions and quadruple parallel mass spectrometry for infant formula. Journal of Chromatography. 1661:462682. https://doi.org/10.1016/j.chroma.2021.462682.

Multi-glycomic characterization of fiber from AOAC methods defines the carbohydrate structures - (Peer Reviewed Journal)
Bacalzo,.P., Couture, G., Ye, C., Luthria, D.L., Phillips, K.M., Fukagawa, N.K., Lebrilla, C.B., Tareq, F.S., Harnly, J.M., Pehrsson, P.R., McKillop, K.A. 2022. Multi-glycomic characterization of fiber from AOAC methods defines the carbohydrate structures. Journal of Agricultural and Food Chemistry. 70(45):14559-14570. https://doi.org/10.1021/acs.jafc.2c06191.

Extractability of Curcuminoids is Enhanced with Milk and Aqueous-Alcohol Mixtures - (Peer Reviewed Journal)
Kotha, R.R., Tareq, F.S., Luthria, D.L. 2022. Extractability of Curcuminoids is Enhanced with Milk and Aqueous-Alcohol Mixtures. ACS Food Science and Technology. 27:4883. https://doi.org/10.3390/molecules27154883.

Mass Spectrometry Based Non-Targeted and Targeted Analytical Approaches in Fingerprinting and Metabolomics of Food and Agricultral Research - (Review Article)
Zhihao, L., Mengliang, Z., Chen, P., Harnly, J.M., Sun, J. 2022. Mass spectrometry based non-targeted and targeted analytical approaches in fingerprinting and metabolomics of food and agricultral research. Journal of Agriculture and Food Chemistry. 70(36):11138–11153. https://doi.org/10.1021/acs.jafc.2c01878.

Deep learning accurately predicts food categories and nutrients based on ingredient statements - (Peer Reviewed Journal)
Ma, P., Wang, Q., Yu, N., Li, Y., Zhang, Z., Sheng, J., Ahuja, J.K., Mcginty, H. 2022. Deep learning accurately predicts food categories and nutrients based on ingredient statements. Food Chemistry. 391:133243. https://doi.org/10.1016/j.foodchem.2022.133243.

Contrast study on secondary metabolite profile between pastas made from three single varietal common bean (Phaseolus vulgaris L.) and durum wheat (Triticum durum) - (Peer Reviewed Journal)
Geng, P., Hooper, S., Sun, J., Chen, P., Cichy, K.A., Harnly, J.M. 2022. Contrast study on secondary metabolite profile between pastas made from three single varietal common bean (Phaseolus vulgaris L.) and durum wheat (Triticum durum). ACS Food Science and Technology. 2(5):895–904. https://doi.org/10.1021/acsfoodscitech.2c00050.

Comparison of Phytochemical Profile of Wild and Cultivated American Ginseng using Metabolomics by Ultra-High Performance Liquid Chromatography-High-Resolution Mass Spectrometry - (Peer Reviewed Journal)
Liu, Z., Gao, Y., Chen, P., Moore, R., Sun, J., Zhang, M. 2022. Comparison of Phytochemical Profile of Wild and Cultivated American Ginseng using Metabolomics by Ultra-High Performance Liquid Chromatography-High-Resolution Mass Spectrometry. Molecules. 28:1. https://doi.org/10.3390/molecules28010009.

Profiling of polyphenols and glucosinolates in kale and broccoli microgreens grown under chamber and windowsill conditions by ultrahigh-performance liquid chromatography high-resolution mass spectrometry - (Peer Reviewed Journal)
Liu, Z., Shi, J., Wan, J., Pham, Q., Zhang, Z., Sun, J., Yu, L., Luo, Y., Wang, T.T.Y., Chen, P. 2021. Profiling of polyphenols and glucosinolates in kale and broccoli microgreens grown under chamber and windowsill conditions by ultrahigh-performance liquid chromatography high-resolution mass spectrometry. ACS Food Science and Technology. 2(1):101-113. https://doi.org/10.1021/acsfoodscitech.1c00355.

Deriving Information from Complex Data Sets: Impact of Forage on Fatty Acids in Cow Milk - (Peer Reviewed Journal)
Harnly, J.M., Picklo, M., Bukowski, M.R., Kalscheur, K., Magnuson, A.D., Fukagawa, N.K., Finley, J.W. 2021. Deriving information from complex data sets: Impact of forage on fatty acids in cow milk. Journal of Food Composition and Analysis. 107:104179. https://doi.org/10.1016/j.jfca.2021.104179.

Identification of marker compounds for predicting browning of fresh-cut lettuce using untargeted UHPLC-HRMS metabolomics - (Peer Reviewed Journal)
Liu, Z., Sun, J., Teng, Z., Luo, Y., Yu, L., Simko, I., Chen, P. 2021. Identification of marker compounds for predicting browning of fresh-cut lettuce using untargeted UHPLC-HRMS metabolomics. Postharvest Biology and Technology. 180.Article 111626. https://doi.org/10.1016/j.postharvbio.2021.111626.

GC-MS and GC-FID of seven seed oils containing conjugated fatty acids - (Peer Reviewed Journal)
Goldschmidt, R.J., Byrdwell, W.C. 2021. GC-MS and GC-FID of seven seed oils containing conjugated fatty acids. Journal of Chromatographic Science. 43:259–273.. https://doi.org/10.3390/separations8040051.

Two- and three-dimensional chromatography with four dimensions of mass spectrometry, LC2MS4 and LC3MS4: Breaking the rules - (Peer Reviewed Journal)
Byrdwell, W.C. 2021. Two- and three-dimensional chromatography with four dimensions of mass spectrometry, LC2MS4 and LC3MS4: Breaking the rules. Current Trends in Mass Spectrometry. 49: 446–457.

Influence of moderate-to-high salinity on the phytochemical profile of two salinity-tolerant spinach genotypes - (Peer Reviewed Journal)
Tareq, F.S., Kotha, R.R., Ferreira, J.F., Sandhu, D., Luthria, D.L. 2021. Influence of moderate-to-high salinity on the phytochemical profile of two salinity-tolerant spinach genotypes. ACS Food Science and Technology. 1 205–214. https://doi.org/10.1021/acsfoodscitech.0c00034.

Changes in Compositions of Galactolipids, Triacylglycerols, and Tocopherols of Lettuce Varieties (Lactuca sativa L.) with Type, Age, and Light Source - (Peer Reviewed Journal)
Byrdwell, W.C., Kubzdela, ., Goldschmidt, R.J. 2020. Changes in Compositions of Galactolipids, Triacylglycerols, and Tocopherols of Lettuce Varieties (Lactuca sativa L.) with Type, Age, and Light Source. Journal of Agricultural and Food Chemistry. 4:242-248. https://doi.org/10.1016/j.jfca.2020.103631.

Comparison of Phytochemical Composition of Ginkgo biloba Extracts Using a Combination of Non-targeted and Targeted Analytical Approaches - (Peer Reviewed Journal)
Collins, B., Rider, C., Waidyanatha, ., Mueller, G., Derose, E., London, R., Kerns, S., Aillon,, K., Harnly, J.M. 2020. Comparison of Phytochemical Composition of Ginkgo biloba Extracts Using a Combination of Non-targeted and Targeted Analytical Approaches. Analytical and Bioanalytical Chemistry. 412:6789–6809. https://doi.org/10.1007/s00216-020-02839-7.

A systematic approach to determine the impact of elevated CO2 levels on the chemical composition of wheat (Triticum aestivum) - (Peer Reviewed Journal)
Geng, P., Sun, J., Chen, P., Li, Y., Peng, B., Harnly, J.M. 2020. A systematic approach to determine the impact of elevated CO2 levels on the chemical composition of wheat (Triticum aestivum). Journal of Cereal Science. 95:753. https://doi.org/10.1016/j.jcs.2020.103020.

Identification of Adulteration in Botanical Samples Supplements with Untargeted Metabolomics - (Peer Reviewed Journal)
Kellogg, J.J., Wallace, E.D., Todd, D.A., Cech, N.B., Harnly, J.M. 2020. Identification of Adulteration in Botanical Samples Supplements with Untargeted Metabolomics. Analytical and Bioanalytical Chemistry. 41: 4273-4286. https://doi.org/10.1007/s00216-020-02678-6.

Characterization of Maca (Lepidium meyenii/Lepidium peruvianum) Using a Mass Spectral Fingerprinting, Metabolomic Analysis, and Genetic Sequencing Approach - (Peer Reviewed Journal)
Geng, P., Sun, J., Brand, E., Frame, J., Meissner, H., Stewart, J., Clark, S., Miller, J., Harnly, J.M., Chen, P., Gafner, S. 2020. Characterization of Maca (Lepidium meyenii/Lepidium peruvianum) using a mass spectral fingerprinting, metabolomic analysis, and genetic sequencing approach. Planta Medica. 169:453–468. https://doi.org/10.1055/a-1161-0372.

Analysis of Cranberry Proanthocyanidins Using UPLC - Ion Mobility - High Resolution Mass Spectrometry - (Peer Reviewed Journal)
Wang, Y., Harrington, P.B., Chang, T., Wu, X., Chen, P. 2020. Analysis of cranberry proanthocyanidins using UPLC - ion mobility - high resolution mass spectrometry. Analytical and Bioanalytical Chemistry. 412:3653-3662. https://doi.org/10.1007/s00216-020-02601-z.

Improving Natural Product Research Translation: from Source to Clinical Trial - (Peer Reviewed Journal)

Terms and momenclature used for plant-derived components in nutrition and related research: Efforts toward harmonization - (Peer Reviewed Journal)

Chemical profile and in vitro gut microbiota modulatory, anti-inflammatory and free radical scavenging Properties of chrysanthemum morifolium cv. Fubaiju - (Peer Reviewed Journal)
Li, Y., Hao, Y., Gao, B., Geng, P., Huang, H., Yu, L., Choe, U., Liu, J., Sun, J., Chen, P., Wang, T.T.Y., Yu, L. 2019. Chemical profile and in vitro gut microbiota modulatory, anti-inflammatory and free radical scavenging properties of chrysanthemum morifolium cv. Fubaiju. Journal of Functional Foods. 58:114-122. https://doi.org/10.1016/j.jff.2019.04.053.

Curcumin: Pharmaceutical, Nutraceutical, and Analytical Aspects - (Review Article)

Non-targeted detection of milk powder adulteration by 1H NMR spectroscopy and Conformity Index Analysis - (Peer Reviewed Journal)
Bergana, M., Adams, K., Harnly, J.M., Moore, J., Xie, Z. 2020. Non-targeted detection of milk powder adulteration by 1H NMR spectroscopy and conformity index analysis. Journal of Food Composition and Analysis. https://doi.org/10.1016/j.jfca.2019.01.016.