Research Project: Modification of Diurnal Patterns to Promote Health in Models for Human Metabolic Dysfunction

Location: Dietary Prevention of Obesity-related Disease Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

The protective potential of butyrate against colon cancer cell migration and invasion is critically dependent on cell type - (Peer Reviewed Journal)
Oncel, S., Safratowich, B.D., Zeng, H. 2024. The protective potential of butyrate against colon cancer cell migration and invasion is critically dependent on cell type. Molecular Nutrition and Food Research. 68(20): 1-11. https://doi.org/10.1002/mnfr.202400421.

Metabolomic alteration in adipose specific monocyte chemotactic protein-1 deficient mice fed a high-fat diet - (Peer Reviewed Journal)
Yan, L., Rust, B., Sundaram, S., Nielsen, F.H. 2024. Metabolomic alteration in adipose specific monocyte chemotactic protein-1 deficient mice fed a high-fat diet. Nutrition and Metabolic Insights. 17:1-13. https://doi.org/10.1177/11786388241280859.

Inflammation suppressing effects of statin and annatto-extracted tocotrienol supplementation on bone microstructure, glucose homeostasis, and gut microbiota composition in obese mice - (Peer Reviewed Journal)

Efficacy of butyrate to inhibit colonic cancer cell growth is cell type-specific and apoptosis-dependent - (Peer Reviewed Journal)
Oncel, S., Safratowich, B.D., Lindlauf, J., Liu, Z., Palmer, D., Briske Anderson, M.J., Zeng, H. 2024. Efficacy of butyrate to inhibit colonic cancer cell growth is cell type-specific and apoptosis-dependent. Nutrients. 16(4). Article 529. https://doi.org/10.3390/nu16040529.

Calcium deficiency decreases bone mass without affecting adiposity in ovariectomized rats fed a high-fat diet - (Peer Reviewed Journal)
Cao, J.J., Gregoire, B.R. 2024. Calcium deficiency decreases bone mass without affecting adiposity in ovariectomized rats fed a high-fat diet. Nutrients. 16(4). Article 478. https://doi.org/10.3390/nu16040478.

Time-restricted feeding restores metabolic flexibility in adult mice with excess adiposity - (Peer Reviewed Journal)
Yan, L., Rust, B., Palmer, D. 2024. Time-restricted feeding restores metabolic flexibility in adult mice with excess adiposity. Frontiers in Nutrition. 11:1-14. https://doi.org/10.3389/fnut.2024.1340735.

Time of day of exercise does not affect the beneficial effect of exercise on bone structure in older female rats - (Peer Reviewed Journal)
Gregoire, B.R., Cao, J.J. 2023. Time of day of exercise does not affect the beneficial effect of exercise on bone structure in older female rats. Frontiers in Physiology. 14:1-11. https://doi.org/10.3389/fphys.2023.1142057.

How ICP-OES changed the face of trace element analysis: Review of the global application landscape - (Peer Reviewed Journal)

How icp-oes changed the face of trace element analysis: review of the global application - (Abstract Only)

FSH–blocking therapeutic for osteoporosis and obesity - (Peer Reviewed Journal)
Gera, S., Kuo, T., Korkmaz, F., Sant, D., Demambro, V., Gumerova, A., Sudha, K., Padila, A., Prevot, G., Munitz, J., Teunissen, A., Van Leent, M., Netto, J., Sultana, F., Shelly, E., Kumar, P., Cullen, L., Chatterjee, J., Miyashita, S., Kannangara, H., Bhongade, M., Levleva, K., Muradova, V., Batista, R., Bobinson, C., Macdonald, A., Babunovic, S., Saxena, M., Meseck, M., Caminis, J., Iqbal, J., New, M.I., Ryu, V., Kim, S., Cao, J.J., Zaidi, N., Fayad, Z., Lizneva, D., Rosen, C.J., Yuen, T., Zaidi, M. 2022. FSH–blocking therapeutic for osteoporosis and obesity. eLife. 1-21. https://doi.org/10.7554/eLife.78022.

Anti-siglec-15 antibody prevents the marked bone loss after acute spinal cord injury-induced immobilization in rats - (Peer Reviewed Journal)
Peng, Y., Langermann, S., Kothari, P., Liu, L., Zhao, W., Hu, Y., Chen, Z., Li, J., Cao, J.J., Guo, X., Chen, L., Bauman, W.A., Qin, W. 2023. Anti-siglec-15 antibody prevents the marked bone loss after acute spinal cord injury-induced immobilization in rats. Journal of Bone and Mineral Research Plus. 7(12). Article e10825.

Tumor necrosis factor-a knockout mitigates intestinal inflammation and tumorigenesis in obese Apc1638N mice - (Peer Reviewed Journal)
Li, J., Tang, Y., Lin, T., Zeng, H., Mason, J.B., Lui, Z. 2023. Tumor necrosis factor-a knockout mitigates intestinal inflammation and tumorigenesis in obese Apc1638N mice. Journal of Nutritional Biochemistry. 117. Article 109355. https://doi.org/10.1016/j.jnutbio.2023.109355.

Metabolomic alteration in mammary glands of pubertal mice fed a high-fat diet - (Peer Reviewed Journal)
Yan, L., Rust, B., Sundaram, S., Bukowski, M.R. 2023. Metabolomic alteration in mammary glands of pubertal mice fed a high-fat diet. Nutrition and Metabolic Insights. 16:1-10. https://doi.org/10.1177/11786388221148858.

Effect of dietary geranylgeraniol and green tea polyphenols on glucose homeostasis, bone turnover biomarkers, and bone microstructure in obese mice - (Peer Reviewed Journal)
Shen, C., Dufour, J.M., Miranda, J.M., Kaur, G., Chung, E., Cao, J.J. 2023. Effect of dietary geranylgeraniol and green tea polyphenols on glucose homeostasis, bone turnover biomarkers, and bone microstructure in obese mice. Nutrients. 24(2):1-12. https://doi.org/10.3390/ijms24020979.

Consumption of a high-fat diet alters transcriptional rhythmicity in liver from pube pubertal mice - (Peer Reviewed Journal)
Yan, L., Sundaram, S., Rust, B., Daniel, P., Luann, J., Zeng, H. 2023. Consumption of a high-fat diet alters transcriptional rhythmicity in liver from pube pubertal mice. Frontiers in Nutrition. 9. Article 1068350. https://doi.org/10.3389/fnut.2022.1068350.

Changes of the fecal metabolome accompany an increase in aberrant crypt foci in the colon of C57BL/6 mice fed a high-fat diet - (Peer Reviewed Journal)
Zeng, H., Safratowich, B.D., Cheng, W., Magnuson, A.D., Picklo, M.J. 2022. Changes of the fecal metabolome accompany an increase in aberrant crypt foci in the colon of C57BL/6 mice fed a high-fat diet. Biomedicines. 10(11). Article 2891. https://doi.org/10.3390/biomedicines10112891.

Identification of fecal oncogenic signatures in the inflammatory colon of C57BL/6 mice fed a high fat diet - (Peer Reviewed Journal)
Zeng, H., Safratowich, B.D., Cheng, W., Bukowski, M.R. 2022. Identification of fecal oncogenic signatures in the inflammatory colon of C57BL/6 mice fed a high fat diet. Journal of Nutritional Biochemistry. 111. https://doi.org/10.1016/j.jnutbio.2022.109188.

Alteration in plasma metabolome in high-fat diet-fed monocyte chemotactic protein-1 knockout mice bearing pulmonary metastasis of Lewis lung carcinoma - (Peer Reviewed Journal)
Yan, L., Rust, B.M., Sundaram, S., Picklo, M.J., Bukowski, M.R. 2022. Alteration in plasma metabolome in high-fat diet-fed monocyte chemotactic protein-1 knockout mice bearing pulmonary metastasis of Lewis lung carcinoma. Nutrition and Metabolic Insights. 107. Article 109051. https://doi.org/10.1016/j.jnutbio.2022.109051.

Metabolomes of Lewis lung carcinoma metastases and normal lung tissue from mice fed different diets - (Peer Reviewed Journal)
Yan, L., Sundaram, S., Rust, B., Picklo, M.J., Bukowski, M.R. 2022. Metabolomes of Lewis lung carcinoma metastases and normal lung tissue from mice fed different diets. Journal of Nutritional Biochemistry. 107. Article 109051. https://doi.org/10.1016/j.jnutbio.2022.109051.

Deoxycholic acid modulates cell-junction gene expression and increases intestinal barrier dysfunction in Caco-2 cell monolayers - (Peer Reviewed Journal)
Zeng, H., Safratowich, B.D., Cheng, W., Larson, K.J., Briske Anderson, M.J. 2022. Deoxycholic acid modulates cell-junction gene expression and increases intestinal barrier dysfunction in Caco-2 cell monolayers. Molecular Nutrition and Food Research. https://doi.org/10.3390/molecules27030723.

Calcium consumption is beneficial to bone health in obese, postmenopausal women - (Peer Reviewed Journal)
Cao, J.J. 2022. Calcium consumption is beneficial to bone health in obese, postmenopausal women. Journal of Nutrition. 152:922-923. https://doi.org/10.1093/jn/nxac008.

Mammary tumorigenesis and metabolome in adipose specific monocyte chemotactic protein-1 deficient male MMTV-PyMT mice fed a high-fat diet - (Peer Reviewed Journal)
Yan, L., Sundaram, S., Rust, B.M., Picklo, M.J., Bukowski, M.R. 2021. Mammary tumorigenesis and metabolome in adipose specific monocyte chemotactic protein-1 deficient male MMTV-PyMT mice fed a high-fat diet. Frontiers in Oncology. 11. Article 667843. https://doi.org/10.3389/fonc.2021.667843.

Providing vegetables at the amount recommended by the Dietary Guidelines for Americans decreases urinary acidity and bone turnover: an 8-wk randomized controlled trial - (Peer Reviewed Journal)
Cao, J.J., Jahns, L., Roemmich, J.N. 2021. Providing vegetables at the amount recommended by the Dietary Guidelines for Americans decreases urinary acidity and bone turnover: an 8-wk randomized controlled trial. Journal of Nutrition. 151:3413-3420. https://doi.org/10.1093/jn/nxab255.

Beneficial effect of dietary geranylgeraniol on glucose homeostasis and bone microstructure in obese mice is associated with suppression of proinflammation and modification of gut microbiome - (Peer Reviewed Journal)
Chung, E., Elmassry, M., Cao, J.J., Kaur, G., Dufour, J., Hamood, A., Chwan-Li, S. 2021. Beneficial effect of dietary geranylgeraniol on glucose homeostasis and bone microstructure in obese mice is associated with suppression of proinflammation and modification of gut microbiome. Journal of Agricultural and Food Chemistry. 93:27-37. https://doi.org/10.1016/j.nutres.2021.07.001.

Azoxymethane alters the plasma metabolome to a greater extent in mice fed a high fat diet compared to an AIN-93 diet - (Peer Reviewed Journal)
Zeng, H., Umar, S., Liu, Z., Bukowski, M.R. 2021. Azoxymethane alters the plasma metabolome to a greater extent in mice fed a high fat diet compared to an AIN-93 diet. International Journal of Molecular Sciences. https://doi.org/10.3390/metabo11070448.

Voluntary running of defined distances alters bone microstructure in C57BL6 mice fed a high-fat diet - (Peer Reviewed Journal)
Yan, L., Nielsen, F.H., Sundaram, S., Cao, J.J. 2021. Voluntary running of defined distances alters bone microstructure in C57BL6 mice fed a high-fat diet. Applied Physiology, Nutrition & Metabolism. 46(11):1337-1344. https://doi.org/10.1139/apnm-2021-0061.

Deficiency of PPAR gamma in bone marrow stromal cells does not prevent high-fat diet-induced bone deterioration in mice - (Peer Reviewed Journal)
Cao, J.J., Gregoire, B.R., Michelsen, K.G., Shi, X. 2021. Deficiency of PPAR gamma in bone marrow stromal cells does not prevent high-fat diet-induced bone deterioration in mice. Journal of Nutrition. https://doi.org/10.1093/jn/nxab173.

Dietary selenium requirement for the prevention of glucose intolerance and insulin resistance in middle-aged mice - (Peer Reviewed Journal)
Huang, Y., Zeng, H., Wu, T., Cheng, W. 2021. Dietary selenium requirement for the prevention of glucose intolerance and insulin resistance in middle-aged mice. Journal of Nutrition. 151:1894-1900. https://doi.org/10.1093/jn/nxab053.

Adequacy of calcium and vitamin D reduces inflammation, beta-catenin signaling and dysbiotic Parasutterela bacteria in the colon of C57BL/6 mice fed a Western-style diet - (Peer Reviewed Journal)
Zeng, H., Safratowich, B.D., Liu, Z., Bukowski, M.R., Ishaq, S. 2021. Adequacy of calcium and vitamin D reduces inflammation, beta-catenin signaling and dysbiotic Parasutterela bacteria in the colon of C57BL/6 mice fed a Western-style diet. Journal of Nutritional Biochemistry. 92. Article 108613. https://doi.org/10.1016/j.jnutbio.2021.108613.

Salivary beta amyloid secretion and altered oral microbiome in mouse models of Alzheimer’s disease - (Peer Reviewed Journal)
Floden, A.M., Sohrabi, M., Nookala, S., Cao, J.J., Combs, C.K. 2021. Salivary beta amyloid secretion and altered oral microbiome in mouse models of Alzheimer’s disease. Current Alzheimer Research. 17:1133-1144. https://doi.org/10.2174/1567205018666210119151952.

Electrical stimulation of hindlimb skeletal muscle has beneficial effects on sublesional bone in a rat model of spinal cord injury - (Peer Reviewed Journal)
Zhao, W., Peng, Y., Hu, Y., Guo, X., Li, J., Cao, J.J., Pan, J., Feng, J., Cardoza, C., Jarvis, J., Bauman, W.A., Qin, W. 2020. Electrical stimulation of hindlimb skeletal muscle has beneficial effects on sublesional bone in a rat model of spinal cord injury. Bone. 144. Article 115825. https://doi.org/10.1016/j.bone.2020.115825.

Osteoprotective effect of green tea polyphenols and annatto-extracted tocotrienol in obese mice via enhancing the microbiome vitamin K2 biosynthetic pathways - (Peer Reviewed Journal)
Elmassry, M.M., Chung, E., Cao, J.J., Hamood, A.N., Shen, C. 2020. Osteoprotective effect of green tea polyphenols and annatto-extracted tocotrienol in obese mice via enhancing the microbiome vitamin K2 biosynthetic pathways. Journal of Nutritional Biochemistry. 86. Article 108492. https://doi.org/10.1016/j.jnutbio.2020.108492.

Superior inhibitory efficacy of butyrate over propionate and acetate against human colon cancer cell proliferation via cell cycle arrest and apoptosis - (Peer Reviewed Journal)
Zeng, H., Hamlin, S.K., Safratowich, B.D., Cheng, W., Johnson, L.K. 2020. Superior inhibitory efficacy of butyrate over propionate and acetate against human colon cancer cell proliferation via cell cycle arrest and apoptosis. Nutrition Research. 83:63-72. https://doi.org/10.1016/j.nutres.2020.08.009.

The Metabolome of Mammary Tumors Differs from Normal Mammary Glands but Is not Altered by Time-restricted Feeding under Obesogenic Conditions - (Peer Reviewed Journal)
Yan, L., Sundaram, S., Rust, B.M., Picklo, M.J., Bukowski, M.R. 2020. The metabolome of mammary tumors differs from normal mammary glands but is not altered by time-restricted feeding under obesogenic conditions. Anticancer Research. https://doi.org/10.21873/anticanres.14358.

High-fat diet disrupts diurnal expression of circadian genes in mammary glands of prepubertal mice - (Peer Reviewed Journal)
Sundaram, S., Johnson, L., Yan, L. 2020. High-fat diet disrupts diurnal expression of circadian genes in mammary glands of prepubertal mice. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2020.00349.

Plasma metabolomic changes in mice with time-restricted feeding-attenuated spontaneous metastasis of Lewis lung carcinoma - (Peer Reviewed Journal)
Yan, L., Rust, B.M., Picklo, M.J. 2020. Plasma metabolomic changes in mice with time-restricted feeding-attenuated spontaneous metastasis of Lewis lung carcinoma. Anticancer Research. https://doi.org/10.21873/anticanres.14137.

Butyrate inhibits deoxycholic-acid-resistant colonic cell proliferation via cell cycle arrest and apoptosis - (Peer Reviewed Journal)
Zeng, H., Safratowich, B.D., Wang, T.T., Hamlin, S., Johnson, L. 2020. Butyrate inhibits deoxycholic-acid-resistant colonic cell proliferation via cell cycle arrest and apoptosis. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201901014.