Research Project: Alternatives to Antibiotics Strategies to Control Enteric Diseases of Poultry

Location: Animal Biosciences & Biotechnology Laboratory

Publications (Clicking on the reprint icon will take you to the publication reprint.)

An integrated systematic study for identification of antimicrobial compounds from Bacillus amyloliquefaciences - (Peer Reviewed Journal)
Li, C.Z., Yan, X., Yang, Y., Nou, X., Sun, Z., Lillehoj, H.S., Lu, M., Harlow, K., Rivera-Colon, I. 2024. An integrated systematic study for identification of antimicrobial compounds from Bacillus amyloliquefaciences. Poultry Science. 103. Article e103871. https://doi.org/10.1016/j.psj.2024.103871.

Differential detection of chicken heterodimeric cytokines, interleukin 12 and 23 using their subunit-specific mouse monoclonal antibodies - (Peer Reviewed Journal)
Lee, Y., Kim, W., Nam, H., Lillehoj, H.S. 2024. Differential detection of chicken heterodimeric cytokines, interleukin 12 and 23 using their subunit-specific mouse monoclonal antibodies. Poultry Science. VOL.103/ 103872. https://doi.org/10.1016/j.psj.2024.103872.

The effect of gut microbiota-derived carnosine on mucosal integrity and immunity in broiler chickens challenged with Eimeria maxima - (Peer Reviewed Journal)
Park, I.N., Nam, H., Lee, Y., Wickramasuriya, S.S., Smith, A.H., Rehberger, T.G., Lillehoj, H.S. 2024. The effect of gut microbiota-derived carnosine on mucosal integrity and immunity in broiler chickens challenged with Eimeria maxima. Poultry Science. 103(8). Article e103837. https://doi.org/10.1016/j.psj.2024.103837.

Use of selected plant extracts in controlling and neutralizing toxins and sporozoites associated with Necrotic Enteritis and Coccidiosis - (Peer Reviewed Journal)
Khan, M., Lillehoj, H.S., Lee, Y.H., Adetunji, A., Omaliko, P.C., Kang, H., Nagabhushanam, K., Fasina, Y.O. 2024. Use of selected plant extracts in controlling and neutralizing toxins and sporozoites associated with Necrotic Enteritis and Coccidiosis. Applied Sciences. V.14/3178. https://doi.org/10.3390/app14083178.

Comprehensive genome-wide analysis of the chicken heat shock protein family: identification, genomic organization, and expression profiles in indigenous chicken with highly pathogenic avian influenza infection - (Peer Reviewed Journal)
Truong, A., Tran, H., Chu, N., Nguyen, H., Phan, L., Phan, H., Vu, T., Song, K., Lillehoj, H.S., Hong, Y. 2023. Comprehensive genome-wide analysis of the chicken heat shock protein family: identification, genomic organization, and expression profiles in indigenous chicken with highly pathogenic avian influenza infection. BMC Genomics. vol.24/793. https://doi.org/10.1186/s12864-023-09908-y.

Chicken miR-26a-5p modulates MDA5 during highly pathogenic avian influenza virus infection - (Peer Reviewed Journal)
Vu, T., Heo, J., Kang, S., Kim, C., Lillehoj, H.S., Hon, Y. 2023. Chicken miR-26a-5p modulates MDA5 during highly pathogenic avian influenza virus infection. Developmental and Comparative Immunology. Vol.149/104921. https://doi.org/10.1016/j.dci.2023.104921.

Novel hyperimmune egg yolk IgY antibodies developed against protective antigens of Eimeria and Clostridium perfringens protect against necrotic enteritis - (Peer Reviewed Journal)
Goo, D., Gadde, U., Kim, W., Gay, C.G., Portia, E., Jones, S., Walker, S., Lillehoj, H.S. 2024. Novel hyperimmune egg yolk IgY antibodies developed against protective antigens of Eimeria and Clostridium perfringens protect against necrotic enteritis. Poultry Science. 102. Article e102841. https://doi.org/10.1016/j.psj.2023.102841.

Editorial; immunosuppressive diseases in poultry - (Peer Reviewed Journal)
Li, C.Z., Wang, L., Zhang, S. 2023. Editorial; immunosuppressive diseases in poultry. Frontiers in Immunology. 14:1215513. https://doi.org/10.3389/fimmu.2023.1215513.

Characterization of collagen binding capability of clostridium perfringens isolate collections from broiler chickens - (Peer Reviewed Journal)
Sun, Z., Lu, M., Lillehoj, H.S., Lee, Y., Doo, D., Yuan, B., Yan, X., Li, C.Z. 2023. Characterization of collagen binding capability of clostridium perfringens isolate collections from broiler chickens . Pathogens. 12:778. https://doi.org/10.3390/pathogens12060778.

Beneficial effects of tea extracts, cinnamon oil, and pomegranate on avian coccidiosis - (Peer Reviewed Journal)
Park, I., Nam, H., Wickramasuria, S.S., Lee, Y., Wall, E.H., Sripathy, R., Lillehoj, H.S. 2023. Beneficial effects of tea extracts, cinnamon oil, and pomegranate on avian coccidiosis. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2023.1145367.

Development of a new immunodiagnostic tool for poultry coccidiosis using an antigen capture sandwich assay based on monoclonal antibodies detecting an immunodominant antigen of Eimeria - (Peer Reviewed Journal)
Lee, Y., Lillehoj, H.S. 2023. Development of a new immunodiagnostic tool for poultry coccidiosis using an antigen capture sandwich assay based on monoclonal antibodies detecting an immunodominant antigen of Eimeria. Poultry Science. https://doi.org/10.1016/j.psj.2023.102790.

Effect of dietary organic selenium on growth performance, gut health, and coccidiosis response in broiler chickens - (Peer Reviewed Journal)
Wickramasuriya, S.S., Park, I., Lee, Y., Lillehoj, H.S. 2023. Effect of dietary organic selenium on growth performance, gut health, and coccidiosis response in broiler chickens. Animals. https://doi.org/10.3390/ani13091560.

Short communication: Bacillus subtilis expressing chicken NK-2 peptide enhances the efficacy of EF-1a vaccination in Eimeria maxima-challenged broiler chickens - (Peer Reviewed Journal)
Lee, Y., Park, I.N., Wickramasuriya, S.S., Lillehoj, H.S. 2023. Short communication: Bacillus subtilis expressing chicken NK-2 peptide enhances the efficacy of EF-1a vaccination in Eimeria maxima-challenged broiler chickens. Animals. https://doi.org/10.3390/ani13081383.

Collagen adhesin protein and necrotic enteritis B-like toxin as biomarkers for early diagnosis of necrotic enteritis in commercial broiler chickens - (Peer Reviewed Journal)
Goo, D., Park, I., Nam, H., Lee, Y., Sawall, J., Smith, X., Li, C.Z., Lillehoj, H.S. 2023. Collagen adhesin protein and necrotic enteritis B-like toxin as biomarkers for early diagnosis of necrotic enteritis in commercial broiler chickens. Poultry Science. https://doi.org/10.1016/j.psj.2023.102647.

Oral administration of chicken NK-lysin or recombinant chicken IL-7 improves vaccine efficacy of Eimeria tenella Elongation Factor-1a (EF-1a) against coccidiosis in commercial broiler chickens - (Peer Reviewed Journal)
Lee, Y., Park, I., Lillehoj, H.S. 2023. Oral administration of chicken NK-lysin or recombinant chicken IL-7 improves vaccine efficacy of Eimeria tenella Elongation Factor-1a (EF-1a) against coccidiosis in commercial broiler chickens. Poultry Science. 102:102611. https://doi.org/10.1016/j.psj.2023.102611.

Orally delivered bacillus subtilis expressing chicken NK-2 peptide stabilizes gut microbiota and enhances intestinal health and local immunity in coccidiosis-infected broiler chickens - (Peer Reviewed Journal)
Wickramasuriya, S.S., Park, I., Lee, Y., Richer, L.R., Przybyszewski, C., Gay, C.G., Van Oosterwijk, J.G., Lillehoj, H.S. 2023. Orally delivered bacillus subtilis expressing chicken NK-2 peptide stabilizes gut microbiota and enhances intestinal health and local immunity in coccidiosis-infected broiler chickens. Poultry Science. https://doi.org/10.1016/j.psj.2023.102590.

Molecular characterization and functional analysis of chicken interleukin 1 receptor 2 (chIL-1R2) - (Peer Reviewed Journal)
Truong, A., Tran, H., Nguyen, H., Chu, N., Hong, Y., Lillehoj, H.S., Dang, H., Song, K. 2023. Molecular characterization and functional analysis of chicken interleukin 1 receptor 2 (chIL-1R2). Poultry Science. https://doi.org/10.1016/j.psj.2022.102399.

Evolution of developmental and comparative immunology in poultry: the regulators and the regulated - (Peer Reviewed Journal)
Lu, M., Lee, Y., Lillehoj, H.S. 2022. Evolution of developmental and comparative immunology in poultry: the regulators and the regulated. Developmental and Comparative Immunology. https://doi.org/10.1016/j.dci.2022.104525.

Co-administration of chicken IL-7 or NK-lysin peptide 2 enhances the efficacy of Eimeria elongation factor-1a vaccination against Eimeria maxima infection in broiler chickens - (Peer Reviewed Journal)
Lee, Y., Park, I., Wickramasuriya, S., Ben Arous, J., Koziol, M., Lillehoj, H.S. 2022. Co-administration of chicken IL-7 or NK-lysin peptide 2 enhances the efficacy of Eimeria elongation factor-1a vaccination against Eimeria maxima infection in broiler chickens. Poultry Science. 101:102013. https://doi.org/10.1016/j.psj.2022.102013.

Gut microbiota-derived indole-3-carboxylate influences mucosal integrity and immunity through the activation of the aryl hydrocarbon receptors and nutrient transporters in broiler chickens challenged with Eimeria maxima - (Peer Reviewed Journal)
Park, I., Nam, H., Goo, D., Wickramasuriya, S.S., Zimmerman, N., Smith, A.H., Rehberger, T.G., Lillehoj, H.S. 2022. Gut microbiota-derived indole-3-carboxylate influences mucosal integrity and immunity through the activation of the aryl hydrocarbon receptors and nutrient transporters in broiler chickens challenged with Eimeria maxima. Frontiers in Immunology. 13:867754. https://doi.org/10.3389/fimmu.2022.867754.

Effect of dietary sophorolipids on growth performance and gastrointestinal functionality of chickens infected with Eimeria maxima - (Peer Reviewed Journal)
Park, I., Oh, S., Goo, D., Celi, P., Lillehoj, H.S. 2022. Effect of dietary sophorolipids on growth performance and gastrointestinal functionality of chickens infected with Eimeria maxima. Animal Feed Science and Technology. https://doi.org/10.1016/j.psj.2022.101944.

Development of a sandwich ELISA for the detection of chicken colony stimulating factor 1a - (Peer Reviewed Journal)
Panebra, A., Lillehoj, H.S. 2022. Development of a sandwich ELISA for the detection of chicken colony stimulating factor 1a. Poultry Science. https://doi.org/10.1016/j.psj.2022.101924.

Immunological characterization of chicken tumor necrosis factor-a (TNF-a) using new sets of monoclonal antibodies specific for poultry TNF - (Peer Reviewed Journal)
Lu, M., Lee, Y., Li, C.Z., Lillehoj, H.S. 2022. Immunological characterization of chicken tumor necrosis factor-a (TNF-a) using new sets of monoclonal antibodies specific for poultry TNF. Developmental and Comparative Immunology. https://doi.org/10.1016/j.dci.2022.104374.

Immunization with recombinant haemonchus contortus Y75B8A.8 partially protects local crossbred female goats from haemonchus contortus infection - (Peer Reviewed Journal)
Tian, X., Lu, M., Bu, Y., Zhang, Y., Aimulajiang, K., Liang, M., Li, C.Z., Yan, R., Xu, L., Song, X., Li, X. 2022. Immunization with recombinant haemonchus contortus Y75B8A.8 partially protects local crossbred female goats from haemonchus contortus infection. Frontiers in Veterinary Science. 9:765700. https://doi.org/10.3389/fvets.2022.765700.

Exosomes from H5N1 avian influenza virus-infected chickens regulate antiviral immune responses of chicken immune cells - (Peer Reviewed Journal)
Hong, Y., Truong, A.D., Vu, T.H., Lee, S., Heo, J., Kang, S., Lillehoj, H.S., Hong, Y.H. 2022. Exosomes from H5N1 avian influenza virus-infected chickens regulate antiviral immune responses of chicken immune cells. Veterinary Research. 130:104368. https://doi.org/10.1016/j.dci.2022.104368.

Coccidiosis: Recent progress in host immunity and alternatives to antibiotic strategies - (Review Article)
Lee, Y., Lu, M., Lillehoj, H.S. 2022. Coccidiosis: Recent progress in host immunity and alternatives to antibiotic strategies. Vaccine. 10:215. https://doi.org/10.3390/vaccines10020215.

Role of physiology, immunity, microbiota and enteric diseases in gut health in poultry - (Review Article)
Wickramasuriya, S., Park, I., Lee, K., Lee, Y., Kim, W., Nam, H., Lillehoj, H.S. 2022. Role of physiology, immunity, microbiota and enteric diseases in gut health in poultry. Vaccines. https://doi.org/10.3390/vaccines10020172.

Antimicrobial activity of sophorolipids against Eimeria maxima and Clostridium perfringens, and their effect on growth performance and gut health in necrotic enteritis - (Peer Reviewed Journal)
Park, I., Oh, S., Nam, H., Celi, P., Lillehoj, H.S. 2022. Antimicrobial activity of sophorolipids against Eimeria maxima and Clostridium perfringens, and their effect on growth performance and gut health in necrotic enteritis. Poultry Science. 101:101731. https://doi.org/10.1016/j.psj.2022.101731.

Expression of chicken NK-Lysin and its role in chicken Coccidiosis induced by Eimeria necatrix - (Peer Reviewed Journal)
Kim, W., Min, W., Park, K.I., Lillehoj, H.S., Fernandez-Colorado, C.P., Flores, R.A., Cammayo, P.L., Nguyen, B.T. 2022. Expression of chicken NK-Lysin and its role in chicken Coccidiosis induced by Eimeria necatrix. Korean Journal of Parasitology. 59:439. https://doi.org/10.3347/kjp.2021.59.5.439.

Antibiotic alternative strategies to reduce economic losses due to enteric infections in poultry - (Proceedings)
Sudharaca, S., Lillehoj, H.S. 2021. Antibiotic alternative strategies to reduce economic losses due to enteric infections in poultry. Meeting Abstract. 9-17.

Cytokine-cytokine receptor interactions in the highly pathogenic avian influenza H5N1 virus-infected lungs of genetically disparate Ri chicken lines - (Peer Reviewed Journal)
Vu, T.H., Hong, Y., Truong, A.D., Lee, J., Lee, S., Song, K., Cha, J., Dang, H.V., Tran, H.T., Lillehoj, H.S., Hong, Y.H. 2021. Cytokine-cytokine receptor interactions in the highly pathogenic avian influenza H5N1 virus-infected lungs of genetically disparate Ri chicken lines. Journal of Animal Bioscience. 35 (3):367-376. https://doi.org/10.5713/ab.21.0163.