Research Project: Prevention of Obesity Related Metabolic Diseases by Bioactive Components of Food Processing Waste Byproducts and Mitigation of Food Allergies

Location: Healthy Processed Foods Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Crystal structure of hetero hexameric 11S seed storage protein of hazelnut - (Peer Reviewed Journal)
Guo, F., Zhang, Y., Howard, A., Xu, Y. 2024. Crystal structure of hetero hexameric 11S seed storage protein of hazelnut. Plant Physiology and Biochemistry. 210. Article 108653. https://doi.org/10.1016/j.plaphy.2024.108653.

Discovery of a novel bioactive compound in orange peel polar fraction on the inhibition of trimethylamine and trimethylamine N-oxide through metabolomics approaches and in vitro and vivo assays: feruloylputrescine inhibits - (Peer Reviewed Journal)
Lee, H., Koh, G., Lee, H., Alves, P.L., Yokoyama, W.H., Wang, Y. 2024. Discovery of a novel bioactive compound in orange peel polar fraction on the inhibition of trimethylamine and trimethylamine N-Oxide through metabolomics approaches and in vitro and in vivo assays: Feruloylputrescine inhibits trimethylamine via suppressing cntA/B enzyme. Journal of Agriculture and Food Chemistry. 72(14):7870-7881. https://doi.org/10.1021/acs.jafc.3c09005.

Bioprocessed black rice bran potentiates the growth inhibitory activity of an immune checkpoint inhibitor against murine colon carcinoma - (Peer Reviewed Journal)
Lee, K., Kwon, K., Hwang, W., Lee, W., Kim, J., Lee, S., Kim, S., Friedman, M. 2023. Bioprocessed black rice bran potentiates the growth inhibitory activity of an immune checkpoint inhibitor against murine colon carcinoma. Food and Nutrition Sciences. 14:1149-1171. https://doi.org/10.4236/fns.2023.1412072.

Health benefits of upcycled romaine lettuce powder in mice’s metabolic syndrome - (Peer Reviewed Journal)
Garcia-Rocha, K.F., Capaceta-Osuna, A., Ochoa-Acosta, A., Avena Bustillos, R.D., Osuna-Martinez, U., Cárdenas-Torres, F.I., Yokoyama, W.H., Mchugh, T.H., Teran-Cabanillas, E. 2023. Health benefits of upcycled romaine lettuce powder in mice’s metabolic syndrome. ACS Food Science and Technology. https://doi.org/10.1021/acsfoodscitech.3c00204.

Food allergens of plant origin - (Peer Reviewed Journal)
Zhang, Y., Che, H., Li, C., Jin, T. 2023. Food allergens of plant origin. Foods. 12(11). Article 2232. https://doi.org/10.3390/foods12112232.

Protection of allergic asthma in mice by black rice bran bioprocessed with shiitake mushroom mycelia - (Peer Reviewed Journal)
Kwon, K., Hwang, W., Hee Lee, K., Kim, K., Lee, W., Kim, J., Lee, S., Kim, S., Friedman, M. 2023. Protection of allergic asthma in mice by black rice bran bioprocessed with shiitake mushroom mycelia. Food and Nutrition Sciences. 14:341-368. https://doi.org/10.4236/fns.2023.144023.

Characterization of the proximate composition, lipid oxidation status, and mineral content of mature tree nuts from nine hazelnuts cultivars grown in the United States - (Peer Reviewed Journal)
Breksa Iii, A.P., Vilches, A.M., Liang, P., Toyofuku, N., Haff, R.P. 2024. Characterization of the proximate composition, lipid oxidation status, and mineral content of mature tree nuts from nine hazelnuts cultivars grown in the United States. Journal of Food Quality. 2024. Article 1469136. https://doi.org/10.1155/2024/1469136.

Milk fat globule membrane relieves fatigue via regulation of oxidative stress and gut microbiota in BALB/c mice - (Peer Reviewed Journal)
Zou, X., Yokoyama, W.H., Liu, X., Wang, K., Hong, H., Lou, Y., Tan, Y. 2023. Milk fat globule membrane relieves fatigue via regulation of oxidative stress and gut microbiota in BALB/c mice. Antioxidants. 12(3). Article 712. https://doi.org/10.3390/antiox12030712.

Whey protein hydrolysate renovates age-related and scopolamine-induced cognitive impairment - (Peer Reviewed Journal)
Ding, N., Meng, H., Wu, C., Yokoyama, W.H., Hong, H., Luo, Y., Tan, Y. 2023. Whey protein hydrolysate renovates age-related and scopolamine-induced cognitive impairment. Nutrients. 15(5). Article 1288. https://doi.org/10.3390/nu15051228.

Substitution of cooked kidney beans or ground beef in hypercholesterolemic high fat diets reduces plasma and liver lipids in hamsters - (Peer Reviewed Journal)
Finley, J.W., Holliday, D., Kim, H., Alves Buongiorno, P.L., Shao, D., Bartley, G., Yokoyama, W.H. 2023. Substitution of cooked kidney beans or ground beef in hypercholesterolemic high fat diets reduces plasma and liver lipids in hamsters. Food Production, Processing, and Nutrition. 5. Article 20. https://doi.org/10.1186/s43014-023-00135-2.

IgE binding epitope mapping with TL1A tagged peptides - (Peer Reviewed Journal)
Zhang, Y., Bhardwaj, S.R., Vilches, A.M., Breksa III, A.P., Lyu, S., Chinthrajah, S., Nadeau, K., Jin, T. 2022. IgE binding epitope mapping with TL1A tagged peptides. Molecular Immunology. 153:194-199. https://doi.org/10.1016/j.molimm.2022.12.001.

Expression, purification, characterization, and patient IgE reactivity of new macadamia nut iso-allergen - (Peer Reviewed Journal)
Zhang, Y., Bhardwaj, S.R., Lyu, S., Chinthrajah, S., Nadeau, K., Li, C. 2022. Expression, purification, characterization, and patient IgE reactivity of new macadamia nut iso-allergen. Protein Expression and Purification. 203. Article 106211. https://doi.org/10.1016/j.pep.2022.106211.

Culinary history and health benefits of Brasenia schreberi leaf and hydrocolloids - (Book / Chapter)
Yokoyama, W.H., Pan, J., Kim, H. 2022. Culinary history and health benefits of brasenia schreberi leaf and hydrocolloids. In: Kobori, M., Nabetani, H., Yokoyama, W., Liu, LS. Washoku, Japanese Food. ACS Symposium Series 1430. Washington, DC. American Chemical Society. p. 55-61. https://doi.org/10.1021/bk-2022-1430.ch005.

Effects of kefir lactic acid bacteria-derived postbiotic components on high fat diet-induced gut microbiota and obesity - (Peer Reviewed Journal)
Seo, K., Lee, H., Eor, J., Jeon, H., Yokoyama, W.H., Kim, H. 2022. Effects of kefir lactic acid bacteria-derived postbiotic components on high fat diet-induced gut microbiota and obesity. Food Research International. 157. Article 111445. https://doi.org/10.1016/j.foodres.2022.111445.

Low acrylamide flatbreads prepared from colored rice flours and relationship to asparagine and proximate content of flours and flatbreads - (Peer Reviewed Journal)
Li, X., Kahlon, T.S., Wang, S.C., Friedman, M. 2021. Low acrylamide flatbreads prepared from colored rice flours and relationship to asparagine and proximate content of flours and flatbreads. Foods. 10(12). Article 2909. https://doi.org/10.3390/foods10122909.

Quercetin ameliorates insulin resistance and restores gut microbiome in mice on high fat diets - (Peer Reviewed Journal)
Tan, Y., Tam, C.C., Rolston, M., Alves, P., Chen, L., Meng, S., Hong, H., Chang, S.K., Yokoyama, W.H. 2021. Quercetin ameliorates insulin resistance and restores gut microbiome in mice on high fat diets. Antioxidants. 10(8). Article 1251. https://doi.org/10.3390/antiox10081251.

Evaluation of cellular absorption and metabolism of ß-carotene loaded in nano-carriers after in vitro digestion - (Peer Reviewed Journal)
Chen, L., Yokoyama, W.H., Tam, C.C., Tan, Y., Alves, P., Bartley, G., Zhong, F. 2021. Evaluation of cellular absorption and metabolism of ß-carotene loaded in nano-carriers after in vitro digestion. Journal of Agriculture and Food Chemistry. 69(32):9383-9394. https://doi.org/10.1021/acs.jafc.1c02431.

Cooked black turtle beans ameliorate insulin resistance and restore gut microbiota in C57BL/6J mice on high-fat diets - (Peer Reviewed Journal)
Tan, Y., Tam, C.C., Meng, S., Zhang, Y., Alves, P., Yokoyama, W.H. 2021. Cooked black turtle beans ameliorate insulin resistance and restore gut microbiota in C57BL/6J mice on high-fat diets. Foods. 10(8). Article 1691. https://doi.org/10.3390/foods10081691.

Effect of encapsulation on ß-carotene absorption and metabolism in mice - (Peer Reviewed Journal)
Chen, L., Yokoyama, W.H., Alves, P., Tan, Y., Pan, J., Zhong, F. 2021. Effect of encapsulation on ß-carotene absorption and metabolism in mice. Food Hydrocolloids. 121. Article 107009. https://doi.org/10.1016/j.foodhyd.2021.107009.

Modulating storage stability of binary gel by adjusting the ratios of starch and kappa-carrageenan - (Peer Reviewed Journal)
Lui, B., Zhu, S., Zhong, F., Yokoyama, W.H., Huang, D., Li, Y. 2021. Modulating storage stability of binary gel by adjusting the ratios of starch and kappa-carrageenan. Carbohydrate Polymers. 268. Article 118264. https://doi.org/10.1016/j.carbpol.2021.118264.

Collagen peptides with DPP-IV inhibitory activity from sheep skin and their stability to in vitro gastrointestinal digestion - (Peer Reviewed Journal)
Wang, B., Zhe, Y., Yokoyama, W.H., Chiou, B., Chen, M., Lui, F., Zhong, F. 2021. Collagen peptides with DPP-IV inhibitory activity from sheep skin and their stability to in vitro gastrointestinal digestion. Food and Function. 42. Article 101161. https://doi.org/10.1016/j.fbio.2021.101161.

Identification of a novel major allergen in buckwheat seeds: fag t 6 - (Peer Reviewed Journal)
Chen, F., Li, H., Fan, X., Li, Y., Zhang, C., Zhu, L., Hu, J., Kombe Kombe, A., Xie, J., Yin, D., Zhang, Y., Sun, J., Tang, R., Jin, T. 2021. Identification of a novel major allergen in buckwheat seeds: fag t 6. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.1c01537.

Konjac glucomannan molecular and rheological properties that delay gastric emptying and improve the regulation of appetite - (Review Article)
Guo, L., Yokoyama, W.H., Chen, M., Zhong, F. 2021. Konjac glucomannan molecular and rheological properties that delay gastric emptying and improve the regulation of appetite. Food Hydrocolloids. 120. Article 106894. https://doi.org/10.1016/j.foodhyd.2021.106894.

High protein gluten free snack foods based on whole grain flour and vegetables - (Peer Reviewed Journal)
Kahlon, T.S., Haff, R.P., Brichta, J.L. 2021. High protein gluten free snack foods based on whole grain flour and vegetables. Food and Nutrition Sciences. 12(5):407-417. https://doi.org/10.4236/fns.2021.125031.

Effect of transglutaminase crosslinking on solubility property and mechanical strength of gelatin-zein nanocomposite films - (Peer Reviewed Journal)
Ahammed, S., Liu, F., Wu, J., Khin, M., Yokoyama, W.H., Zhong, F. 2021. Effect of transglutaminase crosslinking on solubility property and mechanical strength of gelatin-zein nanocomposite films. Food Hydrocolloids. 116. Article 106649. https://doi.org/10.1016/j.foodhyd.2021.106649.

Black, pinto and white beans lower hepatic lipids in hamsters fed high fat diets by excretion of bile acids - (Peer Reviewed Journal)
Alves, P.L., Berrios, J.D., Pan, J., Yokoyama, W.H. 2020. Black, pinto and white beans lower hepatic lipids in hamsters fed high fat diets by excretion of bile acids. Food Production, Processing, and Nutrition. 2. Article 25. https://doi.org/10.1186/s43014-020-00039-5.

Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review - (Peer Reviewed Journal)
Friedman, M., Tam, C.C., Cheng, L.W., Land, K.M. 2020. Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review. BMC Complementary Medicine and Therapies. 20:271. https://doi.org/10.1186/s12906-020-03061-9.

Infusion of trans-resveratrol in micron-scale grape skin powder for enhanced stability and bioaccessibility - (Peer Reviewed Journal)
Rai, R., Merrell, C., Yokoyama, W.H., Nitin, N. 2020. Infusion of trans-resveratrol in micron-scale grape skin powder for enhanced stability and bioaccessibility. Food Chemistry. 340. Article 127894. https://doi.org/10.1016/j.foodchem.2020.127894.

Effect of beta-carotene status in microcapsules on its in vivo bioefficacy and in vitro bioaccessibility - (Peer Reviewed Journal)
Chen, X., Liang, R., Zhong, F., Yokoyama, W.H. 2020. Effect of beta-carotene status in microcapsules on its in vivo bioefficacy and in vitro bioaccessibility. Food Hydrocolloids. 106. Article 105848. https://doi.org/10.1016/j.foodhyd.2020.105848.

Chemistry of pterostilbene and its metabolic effects - (Review Article)
Kim, H., Seo, K., Yokoyama, W.H. 2020. Chemistry of pterostilbene and its metabolic effects. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.0c00070.

Hypolipidemic effects of dietary fibre from an artichoke by-product in syrian hamsters - (Peer Reviewed Journal)
Villanueva-Suarez, M., Mateos-Aparicio, I., Perez-Cozar, M., Yokoyama, W.H., Redondo-Cuenca, A. 2019. Hypolipidemic effects of dietary fibre from an artichoke by-product in Syrian hamsters. Journal of Functional Foods. 56:156-162. https://doi.org/10.1016/j.jff.2019.03.013.