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ARS Home » Southeast Area » Oxford, Mississippi » Natural Products Utilization Research » Research » Publications at this Location » Publication #166640
Title: BIOTRANSFORMATION STUDIES OF THE MANZAMINE ALKALOIDS

Author
item KASANAH, N. - UNIVERSITY OF MISSISSIPPI
item RAO, K. - UNIVERSITY OF MISSISSIPPI
item YOUSAF, M. - UNIVERSITY OF MISSISSIPPI
item Wedge, David
item HILL, R. - UNIVERSITY OF MARYLAND
item HAMANN, M. - UNIVERSITY OF MISSISSIPPI

Submitted to: Marine Biotechnology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/22/2004
Publication Date: 11/1/2004
Citation: Kasanah, N., Rao, K., Yousaf, M., Wedge, D.E., Hill, R.T., Hamann, M.T. 2004. Biotransformation studies of the manzamine alkaloids. Marine Biotechnology. 6:268-272.

Interpretive Summary: Manzamines are a group of alkaloids derived from marine sponges that possess a complex heterocyclic ring structure attached to a ß-carboline moiety. The manzamine alkaloids have a diverse range of bioactivity including antitumor and cytotoxicity, anti-inflammatory, antiinfective and antiparasitic, with the greatest potential utility against malaria.

Technical Abstract: The manzamines are complex, polycyclic, marine derived alkaloids that are important as pharmaceutical agents due to their activity as antimalarial, antituberculosis, and antitumor drug-leads. In order to understand the metabolism and biogenesis of the manzamines, we examined the biotransformation of manzamine using a number of microorganisms. Our biotransformation studies have focused both on the improvement of the activity and reduced toxicity of the manzamines that may be generated by sponge-associated microbes. Biotransformation studies of 8-hydroxymanzamine A, manzamine F, and manzamine X showed that the biotransformation products generated in our laboratory are the same as further oxidized manzamine analogs isolated directly from the sponge.