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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #250665
Title: Prior Colonization with an Avirulent Haemophilus parasuis Isolate Prevents Disease from a Subsequent Virulent Challenge with a Heterologous Isolate

Author
item Brockmeier, Susan
item Loving, Crystal
item Mullins, Michael
item Register, Karen
item Nicholson, Tracy

Submitted to: International Pig Veterinary Society (IPVS)
Publication Type: Proceedings
Publication Acceptance Date: 3/30/2010
Publication Date: 7/18/2010
Citation: Brockmeier, S., Loving, C.L., Mullins, M., Register, K.B., Nicholson, T.L. Prior Colonization with an Avirulent Haemophilus parasuis Isolate Prevents Disease from a Subsequent Virulent Challenge with a Heterologous Isolate. In: Proceedings of the Pig Veterinary Society International Congress, July 18-21, Vancouver, Canada. p. 192.

Interpretive Summary:

Technical Abstract: Four groups of pigs were inoculated with a different isolate of Haemophilus parasuis intranasally (SW114, 12939, MN-H, and 29755), with a fifth group serving as sham inoculated controls. Three of the 4 isolates (12939, MN-H, and 29755) caused systemic disease, while the SW114 pigs remained healthy with no clinical signs of disease. The SW114 pigs were then rechallenged with the 12939 isolate to determine if they would be protected from a heterologous virulent strain. Three control pigs were also challenged with 12939. All three control pigs developed systemic disease, but all pigs previously challenged with SW114 remained healthy. Thus, heterologous protection using avirulent isolates is possible.