Crystal Loving

Research Microbiologist

Crystal L. Loving

National Animal Disease Center                                            

Swine Immunology

e-mail: crystal.loving@ars.usda.gov

Phone (515) 337-7364

Fax (515) 337-7428

P.O. Box 70

1920 Dayton Ave.

Ames, IA  50010

 

Degrees:

B.S. Iowa State University, Zoology, 2001
Ph.D. Iowa State University, Immunobiology, 2006
Postdoc - Food and Drug Administration, Bethesda, MD 2006-2008

 

Research Interests:  My research objectives include identifying critical interactions between commensal intestinal microbiota and the developing immune system that contribute to a balanced and healthy pig. This understanding will lead to the development of intervention strategies to limit in-feed antibiotic use and colonization with foodborne pathogens. My laboratory is interested in better understanding the immune cells and molecules that interact with the microbiota throughout the intestinal tract, with a particular focus on the ileum and cecum. These locations harbor very distinct immune cell populations and organisms, and are unique niches for identifying mechanisms in which these two co-evolved systems interact to maintain a balanced and healthy intestinal ecosystem. We are also interested in immunometabolism as a biomarker of animal health and have been exploring change in lymphocyte metabolism under different feed and health conditions. We use various immunological assays and tools to assess the phenotype of immune cell populations and function (cytokine expression, proliferation, metabolism), as well as different husbandry conditions (dietary components, immunomodulators, lactogenic immunity) to monitor intestinal physiological and immunological responses.  

My research has also focused on evaluating the immune response associated with protective immunity against influenza virus in pigs, with an emphasis on identifying correlates of protection associated with live-attenuated influenza virus vaccination. In addition, I've worked on evaluating immune responses following administration of various alternatives to antibiotics to limit disease in swine, including different vaccine platforms and various immunomodulators.

 

Complete list of published work:

http://www.ncbi.nlm.nih.gov/sites/myncbi/crystal.loving.1/bibliography/50040765/public/?sort=date&direction=descending

• Publications

  • (Clicking on the reprint icon will take you to the publication reprint.)
  • Commercially available anti-human/-mouse monoclonal antibodies cross-reactive to agriculture and wildlife species-(Abstract Only)
    
    
  • Conserved B cell signaling, activation, and differentiation in porcine jejunal and ileal Peyer’s patches despite distinct immune landscapes-(Peer Reviewed Journal)
    
    
  • Phenotypic and genomic comparison of three human outbreak and one cattle-associated Shiga toxin-producing Escherichia coli O157:H7 -(Peer Reviewed Journal)
    Peroutka-Bigus, N., Nielsen, D.W., Trachsel, J.M., Mou, K.T., Sharma, V.K., Kudva, I.T., Loving, C.L. 2024. Phenotypic and genomic comparison of three human outbreak and one cattle-associated Shiga toxin-producing Escherichia coli O157:H7. Microbiology Spectrum. https://doi.org/10.1128/spectrum.04140-23.
    
  • Characterizing expression profiles of turkey immune cell populations within peripheral blood using single-cell transcriptomics-(Abstract Only)
    
    
  • Butyrate receptor gene expression in myeloid cells of the lower porcine gastrointestinal tract-(Abstract Only)
    
    
  • Future of immune modulation in animal agriculture -(Literature Review)
    Mcgill, J.L., Loving, C.L., Kehrli, M.E. 2024. Future of immune modulation in animal agriculture. Annual Review of Animal Biosciences. 13. https://doi.org/10.1146/annurev-animal-111523-102209.
    
  • Identification of anti-human and mouse mAb cross-reactive to agriculture and wildlife species-(Abstract Only)
    
    
  • Genetic and functional diversity of Prevotella isolated from the swine intestinal tract-(Abstract Only)
    
    
  • BCG induced innate training in neonatal and weaned pigs is dependent on route of administration-(Abstract Only)
    
    
  • Impact of butyrate on short-chain fatty acid receptor expression in porcine monocytes-(Abstract Only)
    
    
  • Single-cell RNA sequencing reveals CD4+ macrophages are cytotoxic, phagocytic, effector cells highly responsive to B cell-derived signals in the pig small intestine-(Abstract Only)
    
    
  • Altered cytokine production and gene expression by porcine monocytes following neonatal inoculation with bacillus Calmette-Guerin-(Abstract Only)
    
    
  • Detection B cell and antibody-secreting cell populations in pigs at RNA and protein levels-(Abstract Only)
    
    
  • From snoot to tail - A brief review of influenza virus infection and immunity in pigs -(Review Article)
    Ma, W., Loving, C.L., Driver, J.P. 2023. From snoot to tail - A brief review of influenza virus infection and immunity in pigs. Journal of Immunology. https://doi.org/10.4049/jimmunol.2300385.
    
  • Integrative profiling of gene expression and chromatin accessibility elucidates specific transcriptional networks in porcine neutrophils -(Peer Reviewed Journal)
    Herrera Uribe, J., Lim, K., Byrne, K.A., Daharsh, L., Liu, H., Corbett, R.J., Marco, G., Schroyen, M., Koltes, J.E., Loving, C.L., Tuggle, C.K. 2023. Integrative profiling of gene expression and chromatin accessibility elucidates specific transcriptional networks in porcine neutrophils. Frontiers in Genetics. 14. Article 1107462. https://doi.org/10.3389/fgene.2023.1107462.
    
  • Pseudotemporal and spatial organization of B cell activation and differentiation in Peyer’s patches-(Abstract Only)
    
    
  • Alternatives to Antibiotics: neonatal immunomodulation to improve disease resistance in animals-(Abstract Only)
    
    
  • Short transportation did not impact circulating cortisol levels or leukocyte abundance in cattle-(Abstract Only)
    
    
  • Expression of short-chain fatty acid receptors and transporters in the porcine gastrointestinal tract-(Abstract Only)
    
    
  • Regional specialization of intraepithelial T cells and microbiota in the pig intestinal tract-(Abstract Only)
    
    
  • Annotating cell transcriptomes in four immune tissues to establish a porcine single-cell Immune Atlas-(Abstract Only)
    
    
  • Improving blood phenomics: ISU station report-(Abstract Only)
    
    
  • Effects of ß-glucan on Salmonella enterica serovar Typhimurium swine colonization and microbiota alterations -(Peer Reviewed Journal)
    Bearson, S.M., Trachsel, J.M., Bearson, B.L., Loving, C.L., Kerr, B.J., Shippy, D.C., Kiros, T.G. 2023. Effects of ß-glucan on Salmonella enterica serovar Typhimurium swine colonization and microbiota alterations. BMC Porcine Health Management. 9(7). Article 003024. https://doi.org/10.1186/s40813-023-00302-4.
    
  • Definition of regulatory elements and transcription factors controlling immune cell gene expression at single cell resolution using single cell ATAC-Seq-(Abstract Only)
    
    
  • 3’mRNA-Seq analysis of the effects of weaning and influenza infection on gene expression in whole blood of pigs-(Abstract Only)
    
    
  • Integrative profiling of gene expression and chromatin accessibility elucidates specific transcriptional networks in porcine neutrophils-(Abstract Only)
    
    
  • Characterization and applications of advanced regulatory element annotation in circulating porcine immune cells-(Abstract Only)
    
    
  • Effect of dietary ß-glucan on intestinal microbiota diversity and Salmonella vaccine immunogenicity and efficacy in pigs -(Peer Reviewed Journal)
    Loving, C.L., Bearson, S.M., Bearson, B.L., Kerr, B.J., Kiros, T.G., Shippy, D.C., Trachsel, J.M. 2022. Effect of dietary ß-glucan on intestinal microbiota diversity and Salmonella vaccine immunogenicity and efficacy in pigs. Veterinary Microbiology. 278. Article 109648. https://doi.org/10.1016/j.vetmic.2022.109648.
    
  • Intraepithelial lymphocytes in the pig intestine: T cell and innate lymphoid cell contributions to intestinal barrier immunity -(Literature Review)
    Wiarda, J.E., Loving, C.L. 2022. Intraepithelial lymphocytes in the pig intestine: T cell and innate lymphoid cell contributions to intestinal barrier immunity. Frontiers in Immunology. 13. Article 104708. https://doi.org/10.3389/fimmu.2022.1048708.
    
  • Effects of ß-glucan on Salmonella enterica serovar Typhimurium swine colonization and microbiota alterations-(Abstract Only)
    
    
  • Phenotypic and genomic comparison of human outbreak and cattle-associated Escherichia coli O157:H7-(Abstract Only)
    
    
  • Intestinal location- and age-specific variation of intraepithelial T lymphocytes and mucosal microbiota in pigs -(Peer Reviewed Journal)
    Wiarda, J.E., Watkins, H.R., Gabler, N.K., Anderson, C.L., Loving, C.L. 2023. Intestinal location- and age-specific variation of intraepithelial T lymphocytes and mucosal microbiota in pigs. Developmental and Comparative Immunology. 139. Article 104590. https://doi.org/10.1016/j.dci.2022.104590.
    
  • Regional epithelial cell diversity in the small intestine of pigs -(Peer Reviewed Journal)
    Wiarda, J.E., Becker, S.R., Sivasankaran, S.K., Loving, C.L. 2022. Regional epithelial cell diversity in the small intestine of pigs. Journal of Animal Science. 101. Article eskac318. https://doi.org/10.1093/jas/skac318.
    
  • Evaluation of digestively resistant or soluble fibers, short- and medium-chain fatty acids, trace minerals, and antibiotics in nonchallenged nursery pigs on performance, digestibility, and intestinal integrity -(Peer Reviewed Journal)
    Kerr, B.J., Trachsel, J.M., Bearson, B.L., Loving, C.L., Bearson, S.M., Byrne, K.A., Pearce, S.C., Ramirez, S.M., Gabler, N.K., Schweer, W.P., Helm, E.T., De Mille, C.M. 2022. Evaluation of digestively resistant or soluble fibers, short- and medium-chain fatty acids, trace minerals, and antibiotics in nonchallenged nursery pigs on performance, digestibility, and intestinal integrity. Journal of Animal Science. 100(11). Article skac282. https://doi.org/10.1093/jas/skac282.
    
  • Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells -(Peer Reviewed Journal)
    Wiarda, J.E., Trachsel, J.M., Sivasankaran, S.K., Tuggle, C.K., Loving, C.L. 2022. Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells. Life Science Alliance. 5(10). Article e202201442. https://doi.org/10.26508/lsa.202201442.
    
  • Assessment of DNA methylation in porcine immune cells reveals novel regulatory elements associated with cell-specific gene expression and immune capacity traits -(Peer Reviewed Journal)
    Corbett, R.J., Luttmann, A.M., Herrera-Uribe, J., Liu, H., Raney, N.E., Grabowski, J.M., Loving, C.L., Tuggle, C.K., Ernst, C.W. 2022. Assessment of DNA methylation in porcine immune cells reveals novel regulatory elements associated with cell-specific gene expression and immune capacity traits. Biomed Central (BMC) Genomics. 23(1). Article 575. https://doi.org/10.1186/s12864-022-08773-5.
    
  • Diversity of Alternative Splicing in Porcine Peripheral Blood Immune Cells-(Abstract Only)
    
    
  • Integration of epigenomic and transcriptomic data to identify regulatory elements and networks controlling immune cell-type gene expression in the pig-(Abstract Only)
    
    
  • Short chain fatty acids and bacterial taxa associated with reduced Salmonella enterica serovar I 4,[5],12:i:- Shedding in swine fed a diet supplemented with resistant potato starch -(Peer Reviewed Journal)
    Trachsel, J.M., Bearson, B.L., Kerr, B.J., Shippy, D.C., Byrne, K.A., Loving, C.L., Bearson, S.M. 2022. Short chain fatty acids and bacterial taxa associated with reduced Salmonella enterica serovar I 4,[5],12:i:- Shedding in swine fed a diet supplemented with resistant potato starch. Microbiology Spectrum. 10(3). Article e0220221. https://doi.org/10.1128/spectrum.02202-21.
    
  • Gene signatures for intestinal and peripheral innate lymphoid cells in pigs reveal tissue-specific imprinting and similarities to human cells via single-cell RNA sequencing in pigs-(Abstract Only)
    
    
  • Intravenous BCG induction of innate memory in young pigs-(Abstract Only)
    
    
  • Integrative Profiling of Gene Expression and Chromatin Accessibility Elucidates Specific Transcriptional Networks in Porcine Neutrophils-(Abstract Only)
    
    
  • The impact of carbadox on the swine intestinal microbiota and intraepithelial T cell populations post-weaning-(Abstract Only)
    
    
  • Converse trends with adaptive and innate immune responses following intravenous BCG inoculation in pigs-(Abstract Only)
    
    
  • Characterization of Two Novel Butyrate-Producing Species Isolated From Swine Feces-(Abstract Only)
    
    
  • Reference transcriptomes of porcine peripheral immune cells created through bulk and single-cell RNA sequencing -(Peer Reviewed Journal)
    Herrera-Uribe, J., Wiarda, J., Sivasankaran, S.K., Daharsh, L., Liu, H., Byrne, K.A., Smith, T.P., Lunney, J.K., Loving, C.L., Tuggle, C.K. 2021. Reference transcriptomes of porcine peripheral immune cells created through bulk and single-cell RNA sequencing. Frontiers in Genetics. 12. Article 689406. https://doi.org/10.3389/fgene.2021.689406.
    
  • Characterization of circulating porcine immune cells using single-cell RNA-sequencing and comparison to human datasets-(Abstract Only)
    
    
  • Butyrate alters lipopolysaccharide-induced inflammatory response by porcine monocytes-(Abstract Only)
    
    
  • Integrative profiling of chromatin accessibility and gene expression elucidate specific transcriptional network in porcine neutrophils-(Abstract Only)
    
    
  • Mucosal IFN-¿ production and potential role in protection in Escherichia coli O157:H7 vaccinated and challenged cattle -(Peer Reviewed Journal)
    Schaut, R.G., Palmer, M.V., Boggiatto, P.M., Kudva, I.T., Loving, C.L., Sharma, V.K. 2021. Mucosal IFN-¿ production and potential role in protection in Escherichia coli O157:H7 vaccinated and challenged cattle. Infection and Immunity. 11. Article 9769. https://doi.org/10.1038/s41598-021-89113-7.
    
  • Single cell and deep transcriptomic analysis identify common and cell type specific genes in porcine immune cell-(Abstract Only)
    
    
  • The role of Salmonella Genomic Island 4 in metal tolerance of Salmonella enterica serovar I 4,[5],12:i:- pork outbreak isolate USDA15WA-1 -(Peer Reviewed Journal)
    Bearson, B.L., Trachsel, J.M., Shippy, D.C., Sivasankaran, S.K., Kerr, B.J., Loving, C.L., Brunelle, B.W., Curry, S.M., Gabler, N.K., Bearson, S.M. 2020. The role of Salmonella Genomic Island 4 in metal tolerance of Salmonella enterica serovar I 4,[5],12:i:- pork outbreak isolate USDA15WA-1. Genes. 11(11). Article 1291. https://doi.org/10.3390/genes11111291.
    
  • Differential induction of innate memory in porcine monocytes by B-glucan or bacillus Calmette-Guerin -(Peer Reviewed Journal)
    Byrne, K.A., Tuggle, C., Loving, C.L. 2020. Differential induction of innate memory in porcine monocytes by B-glucan or bacillus Calmette-Guerin. Innate Immunity. https://doi.org/10.1177/1753425920951607.
    
  • Changes in H3K27ac at gene regulatory regions in porcine alveolar macrophages following LPS or PolyIC exposure -(Peer Reviewed Journal)
    Uribe, J.H., Liu, H., Byrne, K.A., Bond, Z.F., Loving, C.L., Tuggle, C. 2020. Changes in H3K27ac at gene regulatory regions in porcine alveolar macrophages following LPS or PolyIC exposure. Frontiers in Genetics. 11. https://doi.org/10.3389/fgene.2020.00817.
    
  • Evaluation of the recombinant proteins RlpB and VacJ as a vaccine for protection against Glaesserella parasuis in pigs -(Peer Reviewed Journal)
    Hau, S.J., Luan, S., Loving, C.L., Nicholson, T.L., Wang, J., Peters, S.E., Seilly, D., Weinert, L., Langford, P.R., Rycroft, A., Wren, B.W., Maskell, D.J., Tucker, A.W., Brockmeier, S. 2020. Evaluation of the recombinant proteins RlpB and VacJ as a vaccine for protection against Glaesserella parasuis in pigs. BMC Veterinary Research. 16:167. https://doi.org/10.1186/s12917-020-02377-5.
    
  • Intraepithelial T cells diverge by intestinal location as pigs age -(Peer Reviewed Journal)
    Wiarda, J.E., Trachsel, J.M., Bond, Z.F., Byrne, K.A., Gabler, N.K., Loving, C.L. 2020. Intraepithelial T cells diverge by intestinal location as pigs age. Frontiers in Immunology. 11:1139. https://doi.org/10.3389/fimmu.2020.01139.
    
  • Innate immunomodulation in food animals: evidence for trained immunity? -(Peer Reviewed Journal)
    Byrne, K.A., Loving, C.L., McGill, J.L. 2020. Innate immunomodulation in food animals: evidence for trained immunity? Frontiers in Immunology. 11:1099. https://doi.org/10.3389/fimmu.2020.01099.
    
  • Toward antibiotic stewardship: Route of antibiotic administration impacts the microbiota and resistance gene diversity in swine feces -(Peer Reviewed Journal)
    Ricker, N., Trachsel, J.M., Colgan, P., Jones, J., Choi, J., Lee, J., Coetzee, J., Howe, A., Brockmeier, S., Loving, C.L., Allen, H.K. 2020. Toward antibiotic stewardship: Route of antibiotic administration impacts the microbiota and resistance gene diversity in swine feces. Frontiers in Veterinary Science. 7:255. https://doi.org/10.3389/fvets.2020.00255.
    
  • Novel engraftment and T cell differentiation of human hematopoietic cells in Art-/- IL2RG-/SCID pigs -(Peer Reviewed Journal)
    Boettcher, A.N., Li, Y., Ahrens, A.P., Kiupel, M., Byrne, K.A., Loving, C.L., Cino-Ozuna, A., Wiarda, J.E., Adur, M., Schultz, B., Swanson, J.J., Snella, E.M., Ho, C., Charley, S.E., Kiefer, Z.E., Cunnick, J.E., Putz, E.J., Giuseppe, Dell A., Jens, J., Sathe, S., Goldman, F., Westin, E.R., Dekkers, J.C.M., Ross, J.W., Tuggle, C.K. 2020. Novel engraftment and T cell differentiation of human hematopoietic cells in Art-I- IL2RG-IY SCID pigs. Frontiers in Immunology. 11:100. https://doi.org/10.3389/fimmu.2020.00100.
    
  • Detection of Salmonella-specific antibody in swine oral fluids -(Peer Reviewed Journal)
    Atkinson, B.M., Bearson, B.L., Loving, C.L., Zimmerman, J.J., Kich, J.D., Bearson, S.M. 2019. Detection of Salmonella-specific antibody in swine oral fluids. BMC Porcine Health Management. 5(29). https://doi.org/10.1186/s40813-019-0136-7.
    
  • Cattle intestinal microbiota shifts following Escherichia coli O157:H7 vaccination and colonization -(Peer Reviewed Journal)
    Mir, R.A., Schaut, R.A., Allen, H.K., Looft, T.P., Loving, C.L., Kudva, I.T., Sharma, V.K. 2019. Cattle intestinal microbiota shifts following Escherichia coli O157:H7 vaccination and colonization. PLoS One. 14(12):e0226099. https://doi.org/10.1371/journal.pone.0226099.
    
  • Successful development of methodology for detection of hapten-specific contact hypersensitivity (CHS) memory in swine -(Peer Reviewed Journal)
    Putz, E.J., Putz, A.M., Boettcher, A., Charley, S., Sauer, M., Palmer, M.V., Phillips, R., Hostetter, J.M., Loving, C.L., Cunnick, J.E., Tuggle, C.K. 2019. Successful development of methodology for detection of hapten-specific contact hypersensitivity (CHS) memory in swine. PLoS One. 14(10):e0223483. https://doi.org/10.1371/journal.pone.0223483.
    
  • Acute systemic inflammatory response to lipopolysaccharide stimulation in pigs divergently selected for residual feed intake -(Peer Reviewed Journal)
    Liu, H., Feye, K.M., Nguyen, Y.T., Rakhshandeh, A., Loving, C.L., Dekkers, J.C., Gabler, N.K., Tuggle, C.K. 2019. Acute systemic inflammatory response to lipopolysaccharide stimulation in pigs divergently selected for residual feed intake. BMC Genomics. 20(728). https://doi.org/10.1186/s12864-019-6127-x.
    
  • Shifts in the swine nasal microbiota of swine in response to different dosing regimens of oxytetracycline administration -(Peer Reviewed Journal)
    Mou, K.T., Allen, H.K., Alt, D.P., Trachsel, J.M., Hau, S.J., Coetzee, J.F., Holman, D.B., Kellner, S.G., Loving, C.L., Brockmeier, S. 2019. Shifts in the swine nasal microbiota of swine in response to different dosing regimens of oxytetracycline administration. Veterinary Microbiology. 237(1084020). https://doi.org/10.1016/j.vetmic.2019.108386.
    
  • Dietary resistant potato starch alters intestinal microbial communities and metabolites and markers of immune regulation and barrier function -(Peer Reviewed Journal)
    Trachsel, J., Briggs, C., Gabler, N.K., Allen, H.K., Loving, C.L. 2019. Dietary resistant potato starch alters intestinal microbial communities and their metabolites and markers of immune regulation and barrier function in swine. Frontiers in Immunology. 10:1381. https://doi.org/10.3389/fimmu.2019.01381.
    
  • Cellular and mucosal immune responses following vaccination with inactivated mutant of Escherichia coli O157:H7 -(Peer Reviewed Journal)
    Schaut, R.G., Boggiatto, P.M., Loving, C.L., Sharma, V.K. 2019. Cellular and mucosal immune responses following vaccination with inactivated mutant of Escherichia coli O157:H7. Scientific Reports. 9:6401. https://doi.org/10.1038/s41598-019-42861-z.
    
  • Potential use of G-CSF for protection against Streptococcus suis infection in swine -(Peer Reviewed Journal)
    Brockmeier, S., Loving, C.L., Eberle, K.C., Hau, S.J., Mou, K.T., Kehrli Jr., M.E. 2019. Administration of granulocyte-colony stimulating factor (G-CSF) to pigs results in a longer mean survival time after exposure to Streptococcus suis. Veterinary Microbiology. 231:116-119. https://doi.org/10.1016/j.vetmic.2019.03.010.
    
  • Exogenous carbohydrase reduced markers of intestinal and systemic immune activation and decreased Lactobacillus in weaned pigs -(Peer Reviewed Journal)
    Li, Q., Schmitz-Esser, S., Loving, C.L., Gabler, N.K., Gould, S.A., Patience, J.F. 2018. Exogenous carbohydrase added to a starter diet reduced markers of systemic immune activation and decreased Lactobacillus in weaned pigs. Journal of Animal Science. 97(3):1242-1253. https://doi.org/10.1093/jas/sky481.
    
  • Functional annotation of the porcine genome and ISAFG update-(Abstract Only)
    Tuggle, C.K., Zhou, H., Ernst, C.W., Loving, C.L., Koltes, J.E., Reecy, J.M., Ross, P.J., Nonneman, D.J., Smith, T.P.L., Steibel, J.P., Huang, W. 2019. Functional annotation of the porcine genome and ISAFG update [abstract]. In: Plant and Animal Genome Conference XXVII Proceedings, 12-16 Jan 2019, San Diego, CA. pg. 96. W448. Available: https://www.intlpag.org/2019/images/pdf/2019/PAGXXVII-abstracts-workshops.pdf
    
  • Chlortetracycline enhances tonsil colonization and fecal shedding of multidrug-resistant Salmonella enterica serovar Typhimurium DT104 without Major Alterations to the Porcine Tonsillar and Intestinal Microbiota -(Peer Reviewed Journal)
    Holman, D., Bearson, B.L., Allen, H.K., Shippy, D.C., Loving, C.L., Kerr, B.J., Bearson, S.M., Brunelle, B.W. 2018. Chlortetracycline enhances tonsil colonization and fecal shedding of multidrug-resistant Salmonella enterica serovar Typhimurium DT104 without major alterations to the porcine tonsillar and intestinal microbiota. Applied and Environmental Microbiology. 85(4):e02354-18. https://doi.org/10.1128/AEM.02354-18.
    
  • Development of severe combined immunodeficient (SCID) pig models for translational cancer modeling: future insights on how humanized SCID pigs can improve preclinical cancer research -(Peer Reviewed Journal)
    Boettcher, A., Loving, C.L., Cunnick, J., Tuggle, C. 2018. Development of severe combined immunodeficient (SCID) pig models for translational cancer modeling: future insights on how humanized SCID pigs can improve preclinical cancer research. Frontiers in Oncology. 8:559. https://doi.org/10.3389/fonc.2018.00559.
    
  • A dietary carbohydrase blend improved intestinal barrier function and growth rate in nursery pigs fed higher fiber diets -(Peer Reviewed Journal)
    Li, Q., Gabler, N.K., Loving, C.L., Gould, S.A., Patience, J.F. 2018. A dietary carbohydrase blend improved intestinal barrier function and growth rate in weaned pigs fed higher fiber diets. Journal of Animal Science. 96(12):5233-5243. https://doi.org/10.1093/jas/sky383.
    
  • Porcine SIRPA binds to human CD47 to inhibit phagocytosis: Implications for human hematopoietic stem cell transplantation into severe combined immunodeficient (SCID) pigs -(Peer Reviewed Journal)
    Boettcher, A.N., Cunnick, J.E., Powell, E., Egner, T.K., Charley, S.E., Loving, C.L., Tuggle, C.K. 2018. Porcine signal regulatory protein alpha binds to human CD47 to inhibit phagocytosis: Implications for human hematopoietic stem cell transplantation into severe combined immunodeficient pigs. Xenotransplantation. 26(2):e12466. https://doi.org/10.1111/xen.12466.
    
  • Bordetella bronchiseptica colonization limits efficacy, but not immunogenicity, of live-attenuated influenza virus vaccine and enhances pathogenesis after influenza challenge -(Peer Reviewed Journal)
    Hughes, H.R., Brockmeier, S., Loving, C.L. 2018. Bordetella bronchiseptica colonization limits efficacy, but not immunogenicity, of live-attenuated influenza virus vaccine and enhances pathogenesis after influenza challenge. Frontiers in Immunology. 9:2255. https://doi.org/10.3389/fimmu.2018.02255.
    
  • The type of adjuvant in whole inactivated influenza A virus vaccines impacts vaccine-associated enhanced respiratory disease -(Peer Reviewed Journal)
    Souza, C.K., Rajão, D.S., Sandbulte, M.R., Lopes, S., Lewis, N.S., Loving, C.L., Gauger, P.C., Vincent, A.L. 2018. The type of adjuvant in whole inactivated influenza A virus vaccines impacts vaccine-associated enhanced respiratory disease. Vaccine. 36(41):6103-6110. https://doi.org/10.1016/j.vaccine.2018.08.072.
    
  • Vaccination with killed whole-cells of Escherichia coli O157:H7 hha mutant emulsified with an adjuvant induced vaccine strain-specific serum antibodies and reduced E. coli O157:H7 fecal shedding in cattle -(Peer Reviewed Journal)
    Sharma, V.K., Schaut, R.G., Loving, C.L. 2018. Vaccination with killed whole-cells of Escherichia coli O157:H7 hha mutant emulsified with an adjuvant induced vaccine strain-specific serum antibodies and reduced E. coli O157:H7 fecal shedding in cattle. Veterinary Microbiology. 219:190-199. https://doi.10.1016/j.vetmic.2018.04.003.
    
  • Escherichia coli O157:H7 virulence factors differentially impact cattle and bison macrophage killing -(Peer Reviewed Journal)
    Schaut, R.G., Loving, C.L., Sharma, V.K. 2018. Escherichia coli O157:H7 virulence factors differentially impact cattle and bison macrophage killing capacity. Microbial Pathogenesis. 118:251-256. https://doi.org/10.1016/j.micpath.2018.03.045.
    
  • Live virus Immunization (LVI) with a recent 1-7-4 PRRSV isolate elicits broad protection against PRRSV challenge in finishing age swine-(Abstract Only)
    Van Geelen, A.G., Buckley, A., Kulshreshtha, V., Brockmeier, S., Miller, L.C., Fleming, D., Loving, C.L., Faaberg, K.S., Lager, K.M. 2018. Live virus Immunization (LVI) with a recent 1-7-4 PRRSV isolate elicits broad protection against PRRSV challenge in finishing age swine. American Association of Swine Veterinarians 49th Annual Meeting, March 3-6, 2018, San Diego, California. Paper No. 69.
    
  • A soluble and highly fermentable dietary fiber with carbohydrases improved gut barrier integrity markers and growth performance in ETEC challenged pigs -(Peer Reviewed Journal)
    Li, Q., Burrough, E.R., Gabler, N.K., Loving, C.L., Sahin, O.A., Gould, S.A., Patience, J.F. 2019. A soluble and highly fermentable dietary fiber with carbohydrases improved gut barrier integrity markers and growth performance in F18 ETEC challenged pigs. Journal of Animal Science. 97(5):2139-2153. https://doi.org/10.1093/jas/skz093.
    
  • Influence of feeding thermally peroxidized soybean oil on oxidative status in growing pigs -(Peer Reviewed Journal)
    Lindblom, S., Gabler, N., Dilger, R., Olson, Z.F., Loving, C.L., Kerr, B.J. 2018. Influence of feeding thermally peroxidized soybean oil on oxidative status in growing pigs. Journal of Animal Science. 96:545-557. https://doi.org/10.1093/jas/sky005.
    
  • Interferon alpha inhibits viral replication of a live-attenuated porcine reproductive and respiratory syndrome virus vaccine preventing development of an adaptive immune response in swine-(Peer Reviewed Journal)
    Brockmeier, S.L., Loving, C.L., Eberle, K.C., Hau, S.J., Buckley, A., Van Geelen, A., Montiel, N.A., Nicholson, T., Lager, K.M. 2017. Interferon alpha inhibits replication of a live-attenuated porcine reproductive and respiratory syndrome virus vaccine preventing development of an adaptive immune response in swine. Veterinary Microbiology. 212:48-51.
    
  • T cell epitope content comparison (EpiCC) of swine H1 influenza A virus hemagglutinin -(Peer Reviewed Journal)
    Gutierrez, A.H., Rapp-Gabrielson, V., Loving, C.L., Terry, F.E., Moise, L., Martin, W.D., De Groot, A.S. 2017. T cell epitope content comparison (EpiCC) of swine H1 influenza A virus hemagglutinin. Influenza and Other Respiratory Viruses. 11(6):531-542. https://doi.org/10.1111/irv.12513.
    
  • Vaccine development for protection against systemic infections with Streptococcus suis and Haemophilus parasuis in swine-(Abstract Only)
    
    
  • Bordetellosis-(Book / Chapter)
    
    
  • The Bordetella Bps polysaccharide is required for biofilm formation and persistence in the lower respiratory tract of swine-(Peer Reviewed Journal)
    Nicholson, T.L., Brockmeier, S.L., Sukumar, N., Paharik, A.E., Lister, J.L., Horswill, A.R., Kehrli, M.E. Jr., Loving, C.L., Shore, S.M., Deora, R. 2017. The Bordetella Bps polysaccharide is required for biofilm formation and enhances survival in the lower respiratory tract of swine. Infection and Immunity. 00261-17. doi:10.1128/IAI.00261-17.
    
  • The quest for cross protective factors of Haemophilus parasuis using 2-D gel electrophoresis-(Abstract Only)
    
    
  • Effect of in-feed versus injected oxytetracycline on piglet nasal and tonsil microbiota-(Abstract Only)
    
    
  • Comparison of Asian porcine high fever disease isolates of porcine reproductive and respiratory syndrome virus to United States isolates for their ability to cause disease and secondary bacterial infection in swine-(Peer Reviewed Journal)
    Brockmeier, S.L., Loving, C.L., Palmer, M.V., Spear, A., Nicholson, T.L., Faaberg, K.S., Lager, K.M. 2017. Comparison of Asian porcine high fever disease isolates of porcine reproductive and respiratory syndrome virus to United States isolates for their ability to cause disease and secondary bacterial infection in swine. Veterinary Microbiology. 203:6-17.
    
  • Factors affecting induction of peripheral IFN-gamma recall response to influenza A virus vaccination in pigs-(Peer Reviewed Journal)
    Olson, Z.F., Sandbulte, M.R., Kunzler Souza, C., Perez, D.R., Vincent, A.L., Loving, C.L. 2017. Factors affecting induction of peripheral IFN-gamma recall response to influenza A virus vaccination in pigs. Veterinary Immunology and Immunopathology. 185:57-65. doi: 10.1016/j.vetimm.2017.01.009.
    
  • Potential use of G-CSF for protection against Streptococcus suis infection in swine-(Abstract Only)
    Brockmeier, S., Loving, C.L., Kehrli Jr, M.E., Eberle, K.C., Hau, S.J., Mou, K.T., Nicholson, T.L. 2016. Potential use of G-CSF for protection against Streptococcus suis infection in swine. Conference Research Workers Disease Meeting. Paper No. P65.
    
  • Successful protection against heterologous strains of Haemophilus parasuis: the quest for cross protective factors-(Abstract Only)
    
    
  • Pigs with severe combined immunodeficiency (SCID) are impaired in controlling influenza A virus infection-(Peer Reviewed Journal)
    Rajao, D.S., Loving, C.L., Waide, E.H., Gauger, P.C., Dekkers, J.C., Tuggle, C.K., Vincent, A.L. 2017. Pigs with severe combined immunodeficiency are impaired in controlling influenza virus infection. Journal of Innate Immunity. 9(2):193-202.
    
  • Enhancement of innate immunity with granulocyte colony-stimulating factor did not mitigate disease in pigs infected with a highly pathogenic Chinese PRRSV strain-(Peer Reviewed Journal)
    Schlink, S.N., Lager, K.M., Brockmeier, S.L., Loving, C.L., Miller, L.C., Vorwald, A.C., Yang, H., Kehrli, Jr., M.E., Faaberg, K.S. 2016. Enhancement of innate immunity with granulocyte colony-stimulating factor did not mitigate disease in pigs infected with a highly pathogenic Chinese PRRSV strain. Veterinary Immunology and Immunopathology. 179:70-76.
    
  • Prophylactic administration of vector-encoded porcine granulocyte-colony stimulating factor reduces Salmonella shedding,tonsil colonization,& microbiota alterations of the gastrointestinal tract in Salmonella-challenged swine-(Peer Reviewed Journal)
    Bearson, S.M., Bearson, B.L., Loving, C.L., Allen, H.K., Lee, I., Madson, D., Kehrli Jr, M.E. 2016. Prophylactic administration of vector-encoded porcine granulocyte-colony stimulating factor reduces Salmonella shedding, tonsil colonization, and microbiota alterations of the gastrointestinal tract in Salmonella-challenged swine. Frontiers in Veterinary Science. 3:66. doi: 10.3389/fvets.2016.00066.
    
  • In vivo validation of predicted and conserved T cell epitopes in a swine influenza model-(Peer Reviewed Journal)
    Gutierrez, A.H., Loving, C., Moise, L., Terry, F.E., Brockmeier, S.L., Hughes, H.R., Martin, W.D., De Groot, A.S. 2016. In vivo validation of predicted and conserved T cell epitopes in a swine influenza model. PLoS One. 11(7):e0159237.
    
  • Interrogating the plasmidome to determine antibiotic resistance gene mobility within the swine fecal microbiota-(Abstract Only)
    
    
  • NK cells are intrinsically functional in pigs with Severe Combined Immunodeficiency (SCID) caused by spontaneous mutations in the Artemis gene-(Peer Reviewed Journal)
    Powell, E.J., Cunnick, J.E., Knetter, S.M., Loving, C.L., Waide, E.H., Dekkers, J.C., Tuggle, C. 2016. NK cells are intrinsically functional in pigs with Severe Combined Immunodeficiency (SCID) caused by spontaneous mutations in the Artemis gene. Veterinary Immunology and Immunopathology. 175:1-6. doi: 10.1016/j.vetimm.2016.04.008.
    
  • Vaccine-associated enhanced respiratory disease is influenced by hemagglutinin and neuraminidase in whole inactivated influenza virus vaccines-(Peer Reviewed Journal)
    Rajão, D.S., Chen, H., Perez, D.R., Sandbulte, M.R., Gauger, P.C., Loving, C.L., Shanks, G., Vincent, A.L. 2016. Vaccine-associated enhanced respiratory disease is influenced by hemagglutinin and neuraminidase in whole inactivated influenza virus vaccines. Journal of General Virology. 97(7):1489-1499.
    
  • Age at vaccination and timing of infection do not alter vaccine-associated enhanced respiratory disease in influenza A virus infected pigs-(Peer Reviewed Journal)
    Souza, C.K., Rajão, D.S., Loving, C.L., Gauger, P.C., Pérez, D.R., Vincent, A.L. 2016. Age at vaccination and timing of infection do not alter vaccine-associated enhanced respiratory disease in influenza A virus infected pigs. Clinical and Vaccine Immunology. 23:470–482.
    
  • Characterization and vaccine potential of outer membrane vesicles produced by Haemophilus parasuis-(Peer Reviewed Journal)
    McCaig, W.D., Loving, C.L., Hughes, H.R., Brockmeier, S. 2016. Characterization and vaccine potential of outer membrane vesicles produced by Haemophilus parasuis. PLoS One. 11(3):e0149132.
    
  • Heterologous challenge in the presence of maternally-derived antibodies results in vaccine-associated enhanced respiratory disease in weaned piglets-(Peer Reviewed Journal)
    Rajao, D.S., Sandbulte, M.R., Gauger, P.C., Kitikoon, P., Platt, R., Roth, J.A., Perez, D.R., Loving, C.L., Vincent, A.L. 2016. Heterologous challenge in the presence of maternally-derived antibodies results in vaccine-associated enhanced respiratory disease in weaned piglets. Virology. 491:79-88.
    
  • Effects of adenoviral delivered interferon-alpha on porcine reproductive and respiratory syndrome virus infection in swine.-(Abstract Only)
    
    
  • Effects of adenoviral delivered interferon-alpha on porcine reproductive and respiratory syndrome virus infection in swine-(Abstract Only)
    
    
  • Oral fluids as a live-animal sample for evaluating cross-reactivity and cross-protection following intranasal influenza A virus vaccination in pigs-(Peer Reviewed Journal)
    Hughes, H.R., Vincent, A.L., Brockmeier, S.L., Gauger, P.C., Pena, L., Santos, J., Braucher, D.R., Perez, D.R., Loving, C.L. 2015. Oral fluids as a live-animal sample source for evaluating cross-reactivity and cross-protection following intranasal influenza A virus vaccination in pigs. Clinical and Vaccine Immunology. 22(10):1109-1120.
    
  • Innate and adaptive immunity against porcine reproductive and respiratory syndrome virus-(Literature Review)
    Loving, C.L., Osorio, F.A., Murtaugh, M.P., Zuckermann, F.A. 2015. Innate and adaptive immunity against porcine reproductive and respiratory syndrome virus. Veterinary Immunology and Immunopathology. 167(1-2):1-14.
    
  • Immune mechanisms associated with enhanced influenza A virus disease versus cross-protection in vaccinated pigs.-(Abstract Only)
    
    
  • Isolation and characterization of outer membrane vesicles from Haemophilus parasuis-(Abstract Only)
    
    
  • Partial heterologous protection against Glässer’s disease in pigs colonized with an avirulent isolate of Haemophilus parasuis-(Abstract Only)
    
    
  • Lymphocyte responses in the lungs of vaccinated pigs following homologous and heterologous influenza A virus challenge.-(Abstract Only)
    
    
  • Mucosal correlates of cross-protection for live-attenuated influenza virus vaccines in pigs.-(Abstract Only)
    
    
  • Live attenuated influenza A virus vaccine protects against heterologous challenge with A(H1N1)pdm09 without inducing vaccine associated enhanced respiratory disease-(Peer Reviewed Journal)
    Gauger, P.C., Loving, C.L., Khurana, S., Lorusso, A., Perez, D.R., Kehrli, Jr., M.E., Roth, J.A., Golding, H., Vincent, A.L. 2014. Live attenuated influenza A virus vaccine protects against A(H1N1)pdm09 heterologous challenge without vaccine associated enhanced respiratory disease. Virology. 471-473:93-104.
    
  • Efficacy of type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs-(Peer Reviewed Journal)
    Lager, K.M., Schlink, S.N., Brockmeier, S.L., Miller, L.C., Henningson, J.N., Kappes, M.A., Kehrli, M.E., Loving, C.L., Guo, B., Swenson, S.L., Yang, H., Faaberg, K.S. 2014. Efficacy of type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs. Vaccine. 32(48):6457–6462.
    
  • Polymorphisms in the hemagglutinin gene influenced the viral shedding of pandemic 2009 influenza virus in swine-(Peer Reviewed Journal)
    Lorusso, A., Ciacci-Zanella, J.R., Zanella, E.L., Pena, L., Perez, D.R., Lager, K.M., Rajao, D.S., Loving, C.L., Kitikoon, P., Vincent, A.L. 2014. Polymorphisms in the hemagglutinin gene influenced the viral shedding of pandemic 2009 influenza virus in swine. Journal of General Virology. 95(Pt 12):2618-2626.
    
  • Introduction of plasmid DNA into an ST398 livestock-associated methicillin-resistant Staphylococcus aureus strain-(Abstract Only)
    Plaut, R.D., Riggins, D.P., Boatwright Jr, W.D., Loving, C.L., Register, K.B., Nicholson, T.L., Stibitz, S. 2014. Introduction of plasmid DNA into an ST398 livestock-associated methicillin-resistant Staphylococcus aureus strain. 2014 Molecular Genetics of Bacteria and Phages Meeting. Paper No. 47. p. 3.
    
  • Influenza A virus hemagglutinin protein subunit vaccine elicits vaccine-associated enhanced respiratory disease-(Peer Reviewed Journal)
    Rajão, D.S., Loving, C.L., Gauger, P.C., Kitikoon, P., Vincent, A.L. 2014. Influenza A virus hemagglutinin protein subunit vaccine elicits vaccine-associated enhanced respiratory disease. Vaccine. 32(40):5170-5176.
    
  • Virulence and draft genome sequence overview of multiple strains of the swine pathogen Haemophilus parasuis -(Peer Reviewed Journal)
    Brockmeier, S.L., Register, K.B., Kuehn, J.S., Nicholson, T.L., Loving, C.L., Shore, S.M., Phillips, G.J. 2014. Virulence and draft genome sequence overview of multiple strains of the swine pathogen Haemophilus parasuis. PLoS ONEe. 9(8):e103787.
    
  • Divergent immune responses and disease outcomes in piglets immunized with inactivated and attenuated H3N2 swine influenza vaccines in the presence of maternally-derived antibodies-(Peer Reviewed Journal)
    Sandbulte, M.R., Platt, R., Roth, J.A., Henningson, J.N., Gibson, K.A., Rajao, D.S., Loving, C.L., Vincent, A.L. 2014. Divergent immune responses and disease outcomes in piglets immunized with inactivated and attenuated H3N2 swine influenza vaccines in the presence of maternally-derived antibodies. Virology. 464-465:45–54.
    
  • Mucosal correlates of cross-protection for live-attenuated influenza virus vaccines in pigs-(Abstract Only)
    
    
  • Cross-fostering to prevent maternal cell transfer did not prevent vaccine-associated enhanced respiratory disease that occurred following heterologous influenza challenge of pigs vaccinated in presence of maternal immunity-(Peer Reviewed Journal)
    Loving, C.L., Brockmeier, S.L., Vincent, A.L., Gauger, P.C., Zanella, E.L., Lager, K.M., Kehrli, Jr., M.E. 2014. Cross-fostering to prevent maternal cell transfer did not prevent vaccine-associated enhanced respiratory disease that occurred following heterologous influenza challenge of pigs vaccinated in presence of maternal immunity. Viral Immunology. 27(7):334-342.
    
  • Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic-(Review Article)
    Butler, J.E., Lager, K.M., Golde, W., Faaberg, K.S., Sinkora, M., Loving, C., Zhang, Y.I. 2014. Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic. Immunologic Research. 59(1-3):81-108.
    
  • Comparative studies of the genome, virulence, and protection of 10 Haemophilus parasuis strains-(Abstract Only)
    
    
  • Immune response to influenza A virus hemagglutinin protein is sufficient to induce vaccine-associated enhanced respiratory disease-(Abstract Only)
    Rajão, D.S., Loving, C.L., Gauger, P.C., Kitikoon, P., Vincent, A.L. 2014. Immune response to influenza A virus hemagglutinin protein is sufficient to induce vaccine-associated enhanced respiratory disease. American Society for Virology 33rd Annual Meeting. p. 199.
    
  • Enzyme-linked immunosorbent assay for detection of serum or mucosal isotype specific IgG and IgA whole virus antibody to influenza A virus in swine-(Book / Chapter)
    Gauger, P.C., Loving, C.L., Vincent, A.L. 2014. Enzyme-linked immunosorbent assay for detection of serum or mucosal isotype specific IgG and IgA whole virus antibody to influenza A virus in swine. In: Spackman, E., editor. Methods in Molecular Biology: Animal Influenza Virus. 2nd edition. Springer New York, Humana Press. 1161:303-312.
    
  • Antibody secreting cell assay for influenza A virus in swine-(Book / Chapter)
    Kitikoon, P., Loving, C.L., Vincent, A.L. 2014. Antibody secreting cell assay for influenza A virus in swine. In: Spackman, E., editor. Methods in Molecular Biology, Animal Influenza Virus. 2nd edition. New York, NY: Springer. p. 347-353.
    
  • Reduced salmonella fecal shedding in swine administered porcine granulocyte-colony stimulating factor (G-CSF)-(Abstract Only)
    Bearson, S.M., Bearson, B.L., Loving, C.L., Allen, H.K., Lee, I.S., Kehrli Jr, M.E. 2014. Reduced salmonella fecal shedding in swine administered porcine granulocyte-colony stimulating factor (G-CSF) [abstract]. In: Proceedings of 114th General Meeting of the American Society for Microbiology, Boston, Massachusetts, May 17-20, 2014. p. 204.
    
  • The Bordetella bronchiseptica type III secretion system is required for persistence and disease severity but not transmission in swine-(Peer Reviewed Journal)
    Nicholson, T.L., Brockmeier, S.L., Loving, C.L., Register, K.B., Kehrli, Jr., M.E., Shore, S.M. 2014. The Bordetella bronchiseptica type III secretion system is required for persistence and disease severity but not transmission in swine. Infection and Immunity. 82(3):1092-1103.
    
  • Swine influenza virus vaccine research and technology: What does the future hold and what are our next steps?-(Proceedings)
    Kehrli Jr, M.E., Vincent, A.L., Loving, C.L., Lager, K.M. 2013. Swine influenza virus vaccine research and technology: What does the future hold and what are our next steps? Swine Disease Conference Proceedings, November 14-15, 2013, Ames, Iowa. p. 16-20.
    
  • Heterologous challenge of weaned piglets in the presence of maternal derived antibodies results in vaccine-associated enhanced respiratory disease-(Abstract Only)
    Rajao, D., Vincent, A.L., Loving, C.L., Sandbulte, M., Kitikoon, P. 2013. Heterologous challenge of weaned piglets in the presence of maternal derived antibodies results in vaccine-associated enhanced respiratory disease [abstract]. 2013 Conference of Research Workers in Animal Diseases, December 8-10, 2013, Chicago, IL. Paper No. 090.
    
  • Comparative virulence and genomic analysis of 10 strains of Haemophilus parasuis-(Abstract Only)
    
    
  • Maternal derived antibodies induce vaccine-associated enhanced respiratory disease in weaned pigs challenged with heterologous virus-(Abstract Only)
    Rajao, D., Vincent, A.L., Loving, C.L., Sandbulte, M., Kitikoon, P. 2014. Maternal derived antibodies induce vaccine-associated enhanced respiratory disease in weaned pigs challenged with heterologous virus. Proceedings of the 45th American Association of Swine Veterinarians Annual Meeting, p.41-47.
    
  • Maternal derived antibodies induce vaccine-associated enhanced respiratory disease in weaned pigs challenged with heterologous virus-(Proceedings)
    Rajao, D., Vincent, A.L., Loving, C.L., Gauger, P.C., Sandbulte, M., Kitikoon, P. 2014. Maternal derived antibodies induce vaccine-associated enhanced respiratory disease in weaned pigs challenged with heterologous virus. Proceedings of 45th American Association of Swine Veterinarians Annual Meeting. p. 51-54.
    
  • Swine influenza virus vaccine serologic cross-reactivity to contemporary U.S. swine H3N2 and efficacy in pigs infected with an H3N2 similar to 2011-2012 H3N2v-(Peer Reviewed Journal)
    Kitikoon, P., Gauger, P.C., Anderson, T.K., Culhane, M.R., Swenson, S., Loving, C.L., Perez, D.R., Vincent, A.L. 2013. Swine influenza virus vaccine serologic cross-reactivity to contemporary US swine H3N2 and efficacy in pigs infected with an H3N2 similar to 2011-2012 H3N2v. Influenza and Other Respiratory Viruses. 7(Suppl. 4):32-41.
    
  • Virulence, transmission, and heterologous protection of four isolates of Haemophilus parasuis -(Peer Reviewed Journal)
    Brockmeier, S.L., Loving, C.L., Mullins, M., Register, K.B., Nicholson, T.L., Wiseman, B.S., Baker, R.B., Kehrli, Jr., M.E. 2013. Virulence, transmission, and heterologous protection of four isolates of Haemophilus parasuis. Clinical and Vaccine Immunology. 20(9):1466-1472.
    
  • The growing diversity of H3N2 influenza A virus in swine and the impact on control in swine and at the human animal interface-(Proceedings)
    Vincent, A.L., Kitikoon, P., Anderson, T.K., Loving, C.L. 2013. The growing diversity of H3N2 influenza A virus in swine and the impact on control in swine and at the human animal interface. Proceedings of the 2013 Allen D Leman Swine Conference. p. 161-63.
    
  • Porcine granulocyte-colony stimulating factor (G-CSF) delivered via replication-defective adenovirus induces a sustained increase in circulating peripheral blood neutrophils-(Peer Reviewed Journal)
    Loving, C.L., Kehrli, M.E., Brockmeier, S.L., Bayles, D.O., Michael, D.D., Schlink, S.N., Lager, K.M. 2013. Porcine granulocyte-colony stimulating factor (G-CSF) delivered via replication-defective adenovirus induces a sustained increase in circulating peripheral blood neutrophils. Biologicals. Available: http://dx.doi.org/10.1016/j.biologicals.2013.07.001.
    
  • Efficacy of inactivated and live-attenuated influenza virus vaccines in pigs against infection and transmission of emerging H3N2 similar to the 2011-2012 H3N2v-(Peer Reviewed Journal)
    Loving, C.L., Lager, K.M., Vincent, A.L., Brockmeier, S.L., Gauger, P.C., Anderson, T.K., Kitikoon, P., Perez, D.R., Kehrli, Jr., M.E. 2013. Efficacy in pigs of inactivated and live attenuated influenza virus vaccines against infection and transmission of an emerging H3N2 similar to the 2011-2012 H3N2v. Journal of Virology. 87(17):9895-903.
    
  • Vaccine-induced anti-HA2 antibodies promote virus fusion and enhance influenza virus respiratory disease-(Peer Reviewed Journal)
    Khurana, S., Loving, C.L., Manischewitz, J., King, L.R., Gauger, P.C., Henningson, J., Vincent, A.L., Golding, H. 2013. Vaccine-induced anti-HA2 antibodies promote virus fusion and enhance influenza virus respiratory disease. Science Translational Medicine. 5(200):200ra114.
    
  • Vaccine-associated enhanced respiratory disease does not interfere with the adaptive immune response following challenge with pandemic A/H1N1 2009-(Peer Reviewed Journal)
    Gauger, P.C., Loving, C.L., Lager, K.M., Janke, B.H., Kehrli, Jr., M.E., Roth, J.A., Vincent, A.L. 2013. Vaccine-associated enhanced respiratory disease does not interfere with the adaptive immune response following challenge with pandemic A/H1N1 2009. Viral Immunology. 26(5):314-321.
    
  • Biotherapeutics as alternatives to antibiotics-(Abstract Only)
    Loving, C.L. 2013. Biotherapeutics as alternatives to antibiotics. 2013 American Veterinary Medical Association (AVMA) Annual Convention, July 19-23, 2013, Chicago, Illinois. Paper No. 13906.
    
  • Divergent immune responses and disease outcomes in piglets immunized with inactivated and attenuated H3N2 swine influenza vaccines in the presence of maternally-derived antibodies-(Abstract Only)
    
    
  • Overview of swine influenza virus vaccine research and technology: What's on the horizon and what do we need to move forward?-(Proceedings)
    Kehrli, Jr., M.E., Vincent, A.L., Gauger, P.C., Kitikoon, P., Anderson, T.K., Loving, C.L., Lager, K.M. 2013. Overview of swine influenza virus vaccine research and technology: What's on the horizon and what do we need to move forward? In: Proceedings of 44th Annual Meeting of the American Association of Swine Veterinarians, San Diego, CA. p. 517-519.
    
  • Cross-reactive immune responses following vaccination with a live-attenuated influenza virus compared to adjuvanted, whole-inactivated virus in pigs-(Abstract Only)
    Loving, C.L., Braucher, D.R., Brockmeier, S.L., Vincent, A.L. 2012. Cross-reactive immune responses following vaccination with a live-attenuated influenza virus compared to adjuvanted, whole-inactivated virus in pigs. Immunological Mechanisms of Vaccination, Keystone Symposia. Paper No. 2038.
    
  • Changes in circulating and thymic lymphocyte populations following infection with strains of North American or highly pathogenic PRRSV-(Abstract Only)
    Loving, C.L., Brockmeier, S.L., Palmer, M.V., Spear, A.R., Faaberg, K.S., Nicholson, T.L. 2012. Changes in circulating and thymic lymphocyte populations following infection with strains of North American or highly pathogenic PRRSV. International PRRS Symposium 2012. Poster No. 77.
    
  • Comparison of the pathogenesis of Asian highly-pathogenic PRRSV isolates to U.S. isolates and their ability to cause secondary bacterial infection in swine-(Abstract Only)
    Brockmeier, S.L., Loving, C.L., Palmer, M.V., Spear, A.R., Faaberg, K.S., Nicholson, T.L. 2012. Comparison of the pathogenesis of Asian highly-pathogenic PRRSV isolates to U.S. isolates and their ability to cause secondary bacterial infection in swine. International PRRS Symposium 2012. Poster No. 64.
    
  • Changes in circulating and thymic lymphocyte populations following infection with strains of North American or highly pathogenic PRRSV-(Abstract Only)
    Loving, C.L., Brockmeier, S.L., Palmer, M.V., Spear, A.R., Faaberg, K.S., Nicholson, T.L. 2012. Changes in circulating and thymic lymphocyte populations following infection with strains of North American or highly pathogenic PRRSV. Conference of Research Workers in Animal Diseases Annual Meeting. Paper No. 185.
    
  • Comparison of Asian highly-pathogenic PRRSV isolates to US isolates for their ability to cause secondary bacterial infection in swine-(Abstract Only)
    Brockmeier, S.L., Loving, C.L., Palmer, M.V., Spear, A.R., Faaberg, K.S., Nicholson, T.L. 2012. Comparison of Asian highly-pathogenic PRRSV isolates to US isolates for their ability to cause secondary bacterial infection in swine. Conference of Research Workers in Animal Diseases. Paper No. 184.
    
  • Converging Science, Medicine, and Agriculture: An Update on Executing the NADC’s ‘One Health Mission’-(Abstract Only)
    
    
  • Biotherapeutics as alternatives to antibiotics: Effects of adenoviral delivered cytokines on innate and adaptive immunity-(Abstract Only)
    
    
  • Intranasal vaccination with replication defective adenovirus-5 encoding influenza hemagglutinin elicits protective immunity to homologous challenge and partial protection to heterologous challenge in pigs-(Peer Reviewed Journal)
    Braucher, D.R., Henningson, J.N., Loving, C.L., Vincent, A.L., Kim, E., Steitz, J., Gambotto, A.A., Kehrli, Jr., M.E. 2012. Intranasal vaccination with replication-defective adenovirus type 5 encoding influenza virus hemagglutinin elicits protective immunity to homologous challenge and partial protection to heterologous challenge in pigs. Clinical and Vaccine Immunology. 19(11):1722-1729.
    
  • Genomic sequence and virulence comparison of four type 2 porcine reproductive and respiratory syndrome virus strains-(Peer Reviewed Journal)
    Brockmeier, S.L., Loving, C.L., Vorwald, A.C., Kehrli, Jr., M.E., Baker, R.B., Nicholson, T.L., Lager, K.M., Miller, L.C., Faaberg, K.S. 2012. Genomic sequence and virulence comparison of four Type 2 porcine reproductive and respiratory syndrome virus strains. Virus Research. 169(1):212-221.
    
  • Strain-dependent effects of PB1-F2 of triple reassortant H3N2 influenza viruses in swine-(Peer Reviewed Journal)
    Pena, L., Vincent, A.L., Loving, C.L., Henningson, J.N., Lager, K.M., Perez, D.R. 2012. Strain-dependent effects of PB1-F2 of triple reassortant H3N2 influenza viruses in swine. Journal of General Virology. 93(10):2204-2214.
    
  • Adenovirus vectored vaccines against influenza a virus do not result in vaccine associated enhanced respiratory disease following heterologous challenge in contrast to whole inactivated virus vaccine-(Abstract Only)
    Henningson, J.N., Braucher, D.R., Vincent, A.L., Loving, C.L., Kitikoon, P., Gauger, P.C., Kehrli, M.E. 2012. Adenovirus vectored vaccines against influenza A virus do not result in vaccine associated enhanced respiratory disease following heterologous challenge in contrast to whole inactivated virus vaccine. American College of Veterinary Pathologists Meeting 63rd Annual Meeting. Paper No. E-2.
    
  • Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine associated enhanced respiratory disease (VAERD)-(Peer Reviewed Journal)
    Vincent, A.L., Ma, W., Lager, K.M., Richt, J.A., Janke, B.H., Sandbulte, M.R., Gauger, P.C., Loving, C.L., Webby, R.J., Garcia-Sastre, A. 2012. Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine associated enhanced respiratory disease. Journal of Virology. 86(19):10597-10605.
    
  • Heightened adaptive immune responses following vaccination with a temperature-sensitive, live-attenuated influenza virus compared to adjuvanted, whole-inactivated virus in pigs-(Peer Reviewed Journal)
    Loving, C.L., Vincent, A.L., Pena, L., Perez, D.R. 2012. Heightened adaptive immune responses following vaccination with a temperature-sensitive, live-attenuated influenza virus compared to adjuvanted, whole-inactivated virus in pigs. Vaccine. 30(40):5830-5838.
    
  • Biotherapeutics as alternatives to antibiotics: effects of IFN-a and G-CSF on innate and adaptive immunity in swine-(Abstract Only)
    
    
  • Comparison of human-like H1 (delta-cluster) influenza A viruses in the swine host-(Peer Reviewed Journal)
    Ciacci Zanella, J.R., Vincent, A.L., Zanella, E.L., Lorusso, A., Loving, C.L., Brockmeier, S.L., Gauger, P.C., Janke, B.H., Gramer, M.R. 2012. Comparison of human-like H1 (delta-cluster) influenza A viruses in the swine host. Influenza Research and Treatment. Available: http://www.hindawi.com/journals/irt/2012/329029/.
    
  • Influenza A virus and secondary bacterial infection in swine-(Abstract Only)
    
    
  • Restored PB1-F2 into the 2009 pandemic H1N1 influenza virus has minimal effects in swine-(Peer Reviewed Journal)
    Pena, L., Vincent, A.L., Loving, C.L., Henningson, J.N., Lager, K.M., Lorusso, A., Perez, D.R. 2012. Restored PB1-F2 into the 2009 pandemic H1N1 influenza virus has minimal effects in swine. Journal of Virology. 86(10):5523-5532.
    
  • Kinetics of lung lesion development and pro-inflammatory cytokine response in pigs with vaccine-associated enhanced respiratory disease induced by challenge with pandemic (2009) A/H1N1 influenza virus-(Peer Reviewed Journal)
    Gauger, P.C., Vincent, A.L., Loving, C.L., Henningson, J.N., Lager, K.M., Janke, B.H., Kehrli Jr, M.E., Roth, J.A. 2012. Kinetics of lung lesion development and pro-inflammatory cytokine response in pigs with vaccine-associated enhanced respiratory disease induced by challenge with pandemic (2009) A/H1N1 influenza virus. Veterinary Pathology. 49(6):900-912.
    
  • The presence of alpha interferon at the time of infection alters the innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus-(Peer Reviewed Journal)
    Brockmeier, S.L., Loving, C.L., Nelson, E.A., Miller, L.C., Nicholson, T.L., Register, K.B., Grubman, M.J., Brough, D.E., Kehrli, Jr., M.E. 2012. The presence of alpha interferon at the time of infection alters the innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus. Clinical and Vaccine Immunology. 19(4):508-514.
    
  • Effects of interferon-alpha on the immune response to porcine reproductive and respiratory syndrome virus-(Peer Reviewed Journal)
    
    
  • Phenotypic modulation of the Bvg+ phase is not required for pathogenesis and transmission of Bordetella bronchiseptica in swine-(Peer Reviewed Journal)
    Nicholson, T.L., Brockmeier, S.L., Loving, C.L., Register, K.B., Kehrli, Jr., M.E., Stibitz, S.E., Shore, S.M. 2012. Phenotypic modulation of the virulent Bvg phase is not required for pathogenesis and transmission of Bordetella bronchiseptica in swine. Infection and Immunity. 80(3):1025-1036.
    
  • Vaccination with NS1-truncated H3N2 swine influenza virus primes T cells and confers cross-protection against an H1N1 heterosubtypic challenge in pigs-(Peer Reviewed Journal)
    Kappes, M.A., Sandbulte, M.R., Platt, R., Wang, C., Lager, K.M., Henningson, J.N., Lorusso, A., Vincent, A.L., Loving, C.L., Roth, J.A., Kehrli Jr, M.E. 2012. Vaccination with NS1-truncated H3N2 swine influenza virus primes T cells and confers cross-protection against an H1N1 heterosubtypic challenge in pigs. Vaccine. 30(2):280-288.
    
  • Influenza A virus in pigs – protection, provocation and predisposition-(Abstract Only)
    
    
  • Enhancement of innate immunity with granulocyte colony-stimulating factor did not prevent disease in pigs infected with a highly pathogenic Chinese PRRSV strain-(Abstract Only)
    Schlink, S.N., Lager, K.M., Brockmeier, S.L., Loving, C.L., Henningson, J.N., Faaberg, K.S., Guo, B., Miller, L.C., Vorwald, A.C., Kehrli, Jr., M.E. 2011. Enhancement of innate immunity with granulocyte colony-stimulating factor did not prevent disease in pigs infected with a highly pathogenic Chinese PRRSV strain. 2011 International PRRS Symposium. Paper No. 59. page 76.
    
  • Modified live virus vaccine induces a distinct immune response profile compared to inactivated influenza A virus vaccines in swine-(Abstract Only)
    Gauger, P., Vincent, A., Loving, C., Lorusso, A., Lager, K., Pena, L., Perez, D. 2011. Modified live virus vaccine induces a distinct immune response profile compared to inactivated influenza A virus vaccines in swine [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 148.
    
  • Sequence and virulence comparison of four North American isolates of porcine reproductive and respiratory syndrome virus-(Abstract Only)
    Brockmeier, S.L., Loving, C.L., Miller, L.C., Vorwald, A.C., Kehrli, Jr., M.E., Baker, R.B., Nicholson, T.L., Lager, K.M., Faaberg, K.S. 2011. Sequence and virulence comparison of four North American isolates of porcine reproductive and respiratory syndrome virus. Conference of Research Workers in Diseases. Paper No. 174. p. 171.
    
  • Intranasal vaccination with Ad5-encoding influenza HA elicits sterilizing immunity to homologous challenge and partial protection to heterologous challenge in pigs-(Abstract Only)
    Braucher, D.R., Henningson, J.N., Loving, C.L., Vincent, A.L., Kim, E., Steitz, J., Gambotto, A.A., Kehrli, Jr., M.E. 2011. Intranasal vaccination with Ad5-encoding influenza HA elicits sterilizing immunity to homologous challenge and partial protection to heterologous challenge in pigs [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 131.
    
  • Host response to secondary bacterial infection associated with antecedent influenza virus infection in pigs – exacerbation associated with vaccination-(Abstract Only)
    Loving, C.L., Vincent, A.L., Brockmeier, S.L., Henningson, J.N., Braucher, D.R., De Souza Rajao, D. 2011. Host response to secondary bacterial infection associated with antecedent influenza virus infection in pigs - exacerbation associated with vaccination [abstract]. Autumn Immunology Conference. Poster No. 140.
    
  • DNA vaccination elicits protective immune responses against pandemic and classic swine influenza viruses in pigs-(Peer Reviewed Journal)
    Gorres, J.P., Lager, K.M., Kong, W.P., Royals, M., Todd, J.P., Vincent, A.L., Wei, C.J., Loving, C.L., Zanella, E.L., Janke, B., Kehrli, Jr., M.E., Nabel, G.J., Rao, S.S. 2011. DNA vaccination elicits protective immune responses against pandemic and classic swine influenza viruses in pigs. Clinical and Vaccine Immunology. 18(11):1987-1995.
    
  • Bordetellosis-(Book / Chapter)
    Brockmeier, S.L., Register, K.B., Nicholson, T.L., Loving, C.L. 2012. Bordetellosis. In: Zimmerman, J., Karriker, L., Ramirez, A., Schwartz, K., Stevenson, G., editors.Diseases of Swine. 10th edition. Ames, IA: Iowa State University Press. pp. 670-679.
    
  • Comparison of Humoral and Cellular Immune Responses to Inactivated Swine Influenza Virus Vaccine in Weaned Pigs-(Peer Reviewed Journal)
    Platt, R., Vincent, A.L., Gauger, P.C., Loving, C.L., Zanella, E.L., Lager, K.M., Kehrli, Jr., M.E., Kimura, K., Roth, J.A. 2011. Comparison of humoral and cellular immune responses to inactivated swine influenza virus vaccine in weaned pigs. Veterinary Immunology and Immunopathology. 142(3-4):252-257.
    
  • HP-PRRSV challenge of 4 and 10-week-old pigs-(Proceedings)
    Lager, K.M., Faaberg, K.S., Guo, B., Brockmeier, S., Henningson, J.N., Schlink, S.N., Miller, L.C., Kappes, M.A., Kehrli, Jr., M.E., Loving, C.L., Nicholson, T.L., Yang, H.C. 2011. HP-PRRSV challenge of 4 and 10-week-old pigs. In: Proceedings of the 5th Asian PRRSpective Symposium, May 10, 2011, Bangkok, Thailand. 6 pages.
    
  • Contribution of Bordetella bronchiseptica Type III secretion system to respiratory disease in swine-(Abstract Only)
    Brockmeier, S., Nicholson, T.L., Loving, C.L., Register, K.B. 2011. Contribution of Bordetella bronchiseptica type III secretion system to respiratory disease in swine [abstract]. American Society for Microbiology 2011 Annual Meeting. Abstract No. 1494.
    
  • Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (delta-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus-(Peer Reviewed Journal)
    Gauger, P.C., Vincent, A.L., Loving, C.L., Lager, K.M., Janke, B.H., Kehrli, Jr., M.E., Roth, J.A. 2011. Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (delta-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus. Vaccine. 29(15):2712-2719.
    
  • Immune responses elicited to a live-attenuated influenza virus vaccine compared to a traditional whole-inactivated virus vaccine for pandemic H1N1in pigs-(Abstract Only)
    Loving, C.L., Vincent, A.L., Pena, L., Perez, D. 2011. Immune responses elicited to a live-attenuated influenza virus vaccine compared to a traditional whole-inactivated virus vaccine for pandemic H1N1 in pigs [abstract]. Keystone Symposium, Immunity in the Respiratory Tract. Poster No. 228. p. 163.
    
  • Innate immune responses to pathogens involved in the porcine respiratory disease complex-(Abstract Only)
    Brockmeier, S.L., Loving, C.L., Vincent, A.L. 2011. Innate immune responses to pathogens involved in the porcine respiratory disease complex [abstract]. Keystone Symposia, Immunity in the Respiratory Tract. Poster No. 114. p. 149.
    
  • Innate Immune Responses are Enhanced in Pigs After Sequential Infection with Influenza Virus and Haemophilus parasuis-(Abstract Only)
    Loving, C.L., Brockmeier, S.L., Vincent, A.L. 2010. Innate immune responses are enhanced in pigs after sequential infection with influenza virus and Haemophilus parasuis [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 165.
    
  • G-CSF Analogue Treatment Increases Peripheral Neutrophil Numbers in Pigs - a Potential Alternative for In-Feed Antibiotics-(Abstract Only)
    Loving, C.L., Brockmeier, S.L., Bayles, D.O., Greenlee, J.J., Lager, K.M., Kehrli, Jr., M.E. 2010. G-CSF analogue treatment increases peripheral neutrophil numbers in pigs - a potential alternative for in-feed antibiotics. Conference of Research Workers in Animal Diseases. Paper No. 140.
    
  • Modifications in the Polymerase Genes of a Swine-Like Triple Reassortant Influenza Virus to Generate Live Attenuated Vaccines Against 2009 Pandemic H1N1 Viruses-(Peer Reviewed Journal)
    Pena, L., Vincent, A.L., Ye, J., Ciacci-Zanella, J.R., Angel, M., Lorusso, A., Gauger, P.C., Janke, B.H., Loving, C.L., Perez, D.R. 2011. Modifications in the polymerase genes of a swine-like triple reassortant influenza virus to generate live attenuated vaccines against 2009 pandemic H1N1 Viruses. Journal of Virology. 85(1):456-469.
    
  • Comparison of Humoral and Cellular Immune Responses to Inactivated Swine Influenza Virus Vaccine in Weaned Pigs-(Abstract Only)
    Platt, R., Gauger, P., Kimura, K., Roth, J., Vincent, A., Loving, C., Zanella, E., Lager, K., Kehrli, M. 2010. Comparison of humoral and cellular immune responses to inactivated swine influenza virus vaccine in weaned pigs [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 085P/85P.
    
  • Use of an Avirulent Isolate of Haemophilus parasuis as a Vaccine-(Abstract Only)
    Brockmeier, S., Register, K.B., Loving, C.L., Nicholson, T.L. 2010. Use of an avirulent Isolate of Haemophilus parasuis as a vaccine. 45th US-Japan Cooperative Program in Natural Resources Panel of Animal and Avian Health Meeting. p 14.
    
  • Safety and efficacy of a novel live attenuated influenza vaccine against pandemic H1N1 in swine-(Peer Reviewed Journal)
    Pena, L., Vincent, A.L., Ye, J., Ciacci-Zanella, J.E., Angel, M., Lorusso, A., Gauger, P.C., Janke, B.H., Loving, C.L., Perez, D.R. 2011. Safety and efficacy of a novel live attenuated influenza vaccine against pandemic H1N1 in swine. Influenza and Other Respiratory Viruses. 5(S1):341-344.
    
  • Influenza Vaccination in the Face of Maternal Antibody Results in Enhanced Pneumonia Following Heterologous, Homosubtypic Influenza Challenge-(Abstract Only)
    Loving, C.L., Brockmeier, S.L., Vincent, A.L., Gauger, P.C., Kehrli, Jr., M.E. 2010. Influenza vaccination in the face of maternal antibody results in enhanced pneumonia following heterologous, homosubtypic influenza challenge [abstract]. Keystone Symposia, Immunological Mechanisms of Vaccination. Paper No. 243.
    
  • Influenza Virus Coinfection with Bordetella bronchiseptica Enhances Bacterial Colonization and Host Responses Exacerbating Pulmonary Lesions-(Peer Reviewed Journal)
    Loving, C.L., Brockmeier, S.L., Vincent, A.L., Palmer, M.V., Sacco, R.E., Nicholson, T.L. 2010. Influenza Virus Coinfection with Bordetella bronchiseptica Enhances Bacterial Colonization and Host Responses Exacerbating Pulmonary Lesions. Microbial Pathogenesis. 49(5):237-245.
    
  • Enhanced Pneumonia and Proinflammatory Cytokine Response in Pigs Challenged with Pandemic 2009 A/H1N1 Influenza Virus Following Vaccination with an Inactivated delta-Cluster H1N2 Virus-(Abstract Only)
    Gauger, P.C., Vincent, A.L., Loving, C.L., Lager, K.M., Janke, B.A., Roth, J.A. 2010. Enhanced pneumonia and proinflammatory cytokine response in pigs challenged with pandemic 2009 A/H1N1 influenza virus following vaccination with an inactivated delta-cluster H1N2 virus [abstract]. International Conference on Emerging Infectious Diseases. Paper No. L1345.
    
  • Investigation of the Function of the Influenza A Virus PB1-F2 Protein During Infection of Swine and Human Cells with a Predominant Circulating Swine Virus Isolate-(Abstract Only)
    Buehler, J., Mccullough, D., Loving, C.L., Vincent, A.L., Lager, K.M., Miller, C. 2010. Investigation of the Function of the Influenza A Virus PB1-F2 Protein During Infection of Swine and Human Cells with a Predominant Circulating Swine Virus Isolate [abstract]. American Society for Virology Meeting. p. 279.
    
  • Prior Colonization with an Avirulent Haemophilus parasuis Isolate Prevents Disease from a Subsequent Virulent Challenge with a Heterologous Isolate-(Proceedings)
    Brockmeier, S., Loving, C.L., Mullins, M., Register, K.B., Nicholson, T.L. Prior Colonization with an Avirulent Haemophilus parasuis Isolate Prevents Disease from a Subsequent Virulent Challenge with a Heterologous Isolate. In: Proceedings of the Pig Veterinary Society International Congress, July 18-21, Vancouver, Canada. p. 192.
    
  • Prior Swine Influenza Virus Infection Enhances Pulmonary Responses to Secondary Haemophilus parasuis Infection-(Proceedings)
    Loving, C.L., Brockmeier, S., Vincent, A.L. 2010. Prior Swine Influenza Virus Infection Enhances Pulmonary Responses to Secondary Haemophilus parasuis Infection. In: Proceedings of the Pig Veterinary Society International Congress, July 18-21, 2010, Vancouver, Canada. p. 264.
    
  • Enhanced Pneumonia With Pandemic 2009 A/H1N1 Swine Influenza Virus in Pigs-(Proceedings)
    Gauger, P.C., Vincent, A.L., Loving, C.L., Lager, K.M. 2010. Enhanced Pneumonia With Pandemic 2009 A/H1N1 Swine Influenza Virus in Pigs. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 255.
    
  • Contribution of the Bordetella Bps Polysaccharide to Biofilm Formation and Respiratory Disease in Swine-(Abstract Only)
    Nicholson, T.L., Brockmeier, S., Loving, C.L., Lu, H., Sloan, G.P., Deora, R. 2010. Contribution of the Bordetella Bps Polysaccharide to Biofilm Formation and Respiratory Disease in Swine [abstract]. American Society for Microbiology. p. 123.
    
  • Antecedent Influenza Virus Infection Enhances Pulmonary Responses to Secondary Haemophilus Infection in a Porcine Co-Infection Model-(Abstract Only)
    Loving, C.L., Brockmeier, S.L., Vincent, A.L. 2010. Antecedent Influenza virus infection enhances pulmonary responses to secondary Haemophilus infection in a porcine co-infection model [abstract]. American Association of Immunologists. Paper No. 803219.
    
  • Swine influenza virus co-infection with Bordetella bronchiseptica enhances bacterial colonization and host immune responses exacerbating pulmonary lesions-(Abstract Only)
    Loving, C.L., Brockmeier, S.L., Vincent, A.L., Palmer, M.V., Sacco, R.E., Nicholson, T.L. 2010. Swine influenza virus co-infection with Bordetella bronchiseptica enhances bacterial colonization and host immune responses exacerbating pulmonary lesions [abstract]. Conference Research Workers Disease Meeting. Paper No. 130.
    
  • Studies of pathogenesis, transmission, heterologous protection, and genomics of four isolates of Haemophilus parasuis-(Abstract Only)
    Brockmeier, S., Loving, C.L., Register, K.B., Nicholson, T.L., Bayles, D.O., Phillips, G.J. 2009. Studies of pathogenesis, transmission, heterologous protection, and genomics of four isolates of Haemophilus parasuis [abstract]. 2009 Conference of Research Workers in Diseases. Abstract No. 15, p. 118.
    
  • Studies of Pathogenesis, Transmission, and Heterologous Protection of Four Isolates of Haemophilus parasuis in a Highly Susceptible Swine Population-(Abstract Only)
    Brockmeier, S., Loving, C.L., Register, K.B., Nicholson, T.L., Bayles, D.O., Phillips, G.J. 2010. Studies of pathogenesis, transmission, and heterologous protection of four isolates of Haemophilus parasuis in a highly susceptible swine population [abstract]. 2010 American Association of Swine Veterinarians Annual Meeting. p. 127-129.
    
  • Characterization and comparative analysis of the genes encoding Haemophilus parasuis outer membrane proteins P2 and P5-(Peer Reviewed Journal)
    Mullins, M.A., Register, K.B., Bayles, D.O., Loving, C.L., Nicholson, T.L., Brockmeier, S.L., Dyer, D.W., Phillips, G.J. 2009. Characterization and Comparative Analysis of the Genes Encoding Haemophilus parasuis Outer Membrane Proteins P2 and P5. Journal of Bacteriology. 191(19):5988-6002.
    
  • Identification and Comparative Analysis of Genes Encoding Outer Membrane Proteins P2 and P5 in Haemophilus parsuis-(Abstract Only)
    Mullins, M.A., Register, K.B., Bayles, D.O., Loving, C.L., Nicholson, T.L., Brockmeier, S.L., Dyer, D.W., Phillips, G.J. 2009. Identification and comparative analysis of genes encoding outer membrane proteins P2 and P5 in Haemophilus parsuis [abstract]. 109th American Society for Microbiology General Meeting. Poster No. Z-034.
    
  • Contribution of Bordetella bronchiseptica Filamentous Hemagglutinin and Pertactin to Respiratory Disease in Swine-(Peer Reviewed Journal)
    Nicholson, T.L., Brockmeier, S., Loving, C.L. 2009. Contribution of Bordetella bronchiseptica Filamentous Hemagglutinin and Pertactin to Respiratory Disease in Swine. Infection and Immunity. 77(5):2136-2146.
    
  • Investigating the porcine immune reponse to Haemophilus parasuis-(Abstract Only)
    
    
  • Differences in immune response of pigs challenged with a high versus low dose inoculum of porcine reproductive and respiratory syndrome virus-(Peer Reviewed Journal)
    Loving, C.L., Brockmeier, S.L., Vincent, A.L., Lager, K.M., Sacco, R.E. 2008. Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus. Viral Immunology. 21(3):315-325.
    
  • Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica-(Proceedings)
    Brockmeier, S., Vincent, A.L., Loving, C.L., Nicholson, T.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica. In: Proceedings of the 20th International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. 1:10.
    
  • Bordetella bronchiseptica Bvg Phase-Dependent Contribution to Colonization, Transmission, and Immune Responses in Pigs-(Abstract Only)
    Loving, C.L., Nicholson, T.L., Brockmeier, S. 2008. Bordetella bronchiseptica Bvg Phase-Dependent Contribution to Colonization, Transmission, and Immune Responses in Pigs [abstract]. American Society for Microbiology Meeting, June 2-4, 2008, Boston, Massachusetts. 2008 CDROM.
    
  • Contribution of Bordetella bronchiseptica Filamentous Hemagglutinin and Pertactin to Respiratory Disease in Swine-(Abstract Only)
    Nicholson, T.L., Brockmeier, S., Loving, C.L. 2008. Contribution of Bordetella bronchiseptica Filamentous Hemagglutinin and Pertactin to Respiratory Disease in Swine [abstract]. American Society for Microbiology Meeting, June 2-4, 2008, Boston, Massachusetts. 2008 CDROM.
    
  • Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica-(Abstract Only)
    Brockmeier, S., Loving, C.L., Nicholson, T.L., Vincent, A.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. American Society for Microbiology Meeting, June 2-4, 2008, Boston, Massachusetts. 2008 CDROM.
    

• Projects

  Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resistance in Animals Cooperative Agreement (A)   Accession Number:431701

  Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resistance in Animals Cooperative Agreement (A)   Accession Number:433863

  Precision Tool Development for Mitigating of Persistent Shiga Toxin Producing Escherichia Coli O157:H7 in a Beef Feedlot Cooperative Agreement (A)   Accession Number:446623

  Intestinal Microbial Ecology and Non-Antibiotic Strategies to Limit Shiga Toxin-Producing Escherichia coli (STEC) and Antimicrobial Resistance Transmission in Food Animals In-House Appropriated (D)   Accession Number:438679

  Precision Bacteriophage Identification Through Machine Learning for Mitigating Persistent Colonization of Shiga Toxin Interagency Reimbursable Agreement (I)   Accession Number:439491

  Development of Vaccines for HPAI in Pigs Related to HPAI Virus in Food Products (HPAI Tissue Distribution) Interagency Reimbursable Agreement (I)   Accession Number:447279

  Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resistance in Animals Interagency Reimbursable Agreement (I)   Accession Number:437396

  Comprehensive Mining of the Blood Cell Transcriptome for Improved Phenomics in Swine Reimbursable Cooperative Agreement (R)   Accession Number:442578

  Computational Analysis of Host, Bacteria, and Microbiome for Development of Strategies to Enhance Health and Food Safety Non-Assistance Cooperative Agreement (S)   Accession Number:444662

  Revealing Mechanisms for Internal Salmonella Colonization and Persistence in Porcine Lymphoid and Fat Tissues Trust Fund Cooperative Agreement (T)   Accession Number:443701

• ARS News Articles

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