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ARS Home » Southeast Area » New Orleans, Louisiana » Southern Regional Research Center » Food Processing and Sensory Quality Research » Research » Publications at this Location » Publication #289790
Title: Phytoalexins, miRNAs and breast cancer: a review of phytochemical mediated miRNA regulation in breast cancer

Author
item TILGHMAN, SYREETA - Xavier University
item RHODES, LYNDSAY - Xavier University
item BRATTON, MELYSSA - Xavier University
item CARRIERE, PATRICK - Xavier University
item PREYAN, LYNEZ - Xavier University
item Boue, Stephen
item MCLACHLAN, JOHN - Tulane School Of Medicine
item BUROW, MATTHEW - Tulane School Of Medicine

Submitted to: Journal of Health Care for the Poor and Underserved
Publication Type: Review Article
Publication Acceptance Date: 1/25/2013
Publication Date: 2/15/2013
Citation: Tilghman, S.L., Rhodes, L.V., Bratton, M., Carriere, P., Preyan, L.C., Boue, S.M., Mclachlan, J., Burow, M.E. 2013. Phytoalexins, miRNAs and breast cancer: a review of phytochemical mediated miRNA regulation in breast cancer. Journal of Health Care for the Poor and Underserved. 24:36-46.

Interpretive Summary: A specific class of RNAs called microRNAs (miRNAs) have been identified. It has been found that miRNAs are associated with many biological processes and disease states, including all stages of cancer from initiation to tumor promotion and progression. These studies demonstrate natural products, including several plant compounds, could alter the expression of specific miRNAs, which may lead to the increased sensitivity of cancer cells to conventional anti-cancer agents, thereby inhibiting tumor growth. This review article highlights recent research in this area.

Technical Abstract: A specific class of endogenous, non-coding RNAs, classified as microRNAs (miRNAs), has been identified. It has been found that miRNAs are associated with many biological processes and disease states, including all stages of cancer from initiation to tumor promotion and progression. These studies demonstrate natural products; including curcumin, isoflavones, indole-3-carbinol (I3C), diindolylmethane (DIM), and epigallocatechin gallate (EGCG), could alter the expression of specific miRNAs, which may lead to the increased sensitivity of cancer cells to conventional anti-cancer agents, thereby inhibiting tumor growth. This review article highlights recent research in this area.