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ARS Home » Plains Area » College Station, Texas » Southern Plains Agricultural Research Center » Food and Feed Safety Research » Research » Publications at this Location » Publication #310524
Title: Achromobactor denitrificans SP1 produces pharmaceutically active 25C prodigiosin upon utilizing hazardous di(2-ethylhexyl)phthalate

Author
item PRADEEP, SELVANESAN - University Of Calicut
item SARATH, MOOLAKKARIYIL - University Of Calicut
item BALACHANDRAN, SREEDHARAN - Mahatma Gandhi College
item SUDHADEVI, RUKMINI - Mahatma Gandhi College
item SADASIVAM, RAMASAMY - Toshvin Analytical P Ltd
item THIRUGHANA, PERUMAL - Quest Life Science Pvt Ltd
item DOBLE, MUKESH - Indian Institute Of Technology Madras
item Anderson, Robin
item BENJAMIN, SAILAS - University Of Calicut

Submitted to: Bioresource Technology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/14/2014
Publication Date: 8/23/2014
Publication URL: http://handle.nal.usda.gov/10113/61144
Citation: Pradeep, S., Sarath, M.K., Balachandran, S., Sudhadevi, R., Sadasivam, R., Thirughana, P.E., Doble, M., Anderson, R.C., Benjamin, S. 2014. Achromobactor denitrificans SP1 produces pharmaceutically active 25C prodigiosin upon utilizing hazardous di(2-ethylhexyl)phthalate. Bioresource Technology. 171:482-486.

Interpretive Summary: The chemical di(2-ethylhexyl)phthalate, or abbreviated to be referred to as DEHP, is a hazardous plasticizer and proven environmental contaminant known to cause various adverse health in humans such as cancer of the liver, toxicity to reproductive organs, and birth defects. DEHP is used abundantly in the production of almost all polyvinylchloride (PVC) plastics, especially those produced for medical use. In the present study, we demonstrate that a novel bacterium recently isolated from soil sludge heavily contaminated with plastic waste can efficiently degrade and transform DEHP wastes from the synthesis of commercial PVC plastic into a novel chemical exhibiting pharmaceutically several attractive properties including anti-bacterial, anti-fungal, and anti-parasitic activity. Results from this research may ultimately provide new environmental friendly technology to remediate PVC plastic waste products into new beneficial compounds that may potentially be used to the reduce carriage of foodborne pathogens and to treat bacterial infections in food-producing animals.

Technical Abstract: Achromobacter denitrificans SP1 isolated from soil sludge heavily contaminated with plastic waste produced a novel pharmaceutically-active 25C prodigiosin analog during growth in a simple mineral salt medium supplemented with hazardous di(2-ethylhexyl)phthalate (DEHP) blended PVC plastics (in situ) or free DEHP (ex situ). In silico studies indicated that A. denitificans SP1 exhibits moderate binding efficiency to the crucial molecular targets such as cycloxygenase-2, ZAP-70 and Jak-3 kinases.