Author
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Miller, William - Bill |
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Yee, Emma |
Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 8/7/2015 Publication Date: 9/17/2015 Citation: Miller, W.G., Yee, E. 2015. Complete genome sequence of Campylobacter gracilis ATCC 33236T. Genome Announcements. 3(6):e01087-15. Interpretive Summary: Campylobacter gracilis is a human periodontal pathogen isolated from deep tissue head, neck and/or lung lesions, and periodontal and endodontal infections. Interestingly, patients with persistent chronic periodontal disease and Crohn’s disease have a higher rate of infection with C. gracilis than patients with persistent chronic periodontal disease and ulcerative colitis. As part of a JCVI/TIGR Campylobacter genome sequencing project in 2009, the genome of C. gracilis was partially sequenced. This report presents the first complete C. gracilis genome. Multiple genes associated with virulence and pathogenicity were identified, indicating that C. gracilis may be responsible for more human illness than previously believed. Technical Abstract: The human oral pathogen Campylobacter gracilis has been isolated from periodontal and endodontal infections, and also from non-oral head, neck or lung infections. This study describes the whole-genome sequence of the human periodontal isolate ATCC 33236T (=FDC 1084), which is the first closed genome for C. gracilis. |