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ARS Home » Pacific West Area » Albany, California » Western Regional Research Center » Produce Safety and Microbiology Research » Research » Publications at this Location » Publication #319625
Title: Complete genome sequence of the Campylobacter ureolyticus clinical isolate RIGS 9880

Author
item Miller, William - Bill
item Yee, Emma
item ON, STEPHEN - Institute Of Environmental Science And Research
item Bono, James - Jim
item ANDERSEN, LEIF - Copenhagen University

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/25/2015
Publication Date: 11/5/2015
Citation: Miller, W.G., Yee, E., On, S., Bono, J.L., Andersen, L.P. 2015. Complete genome sequence of the Campylobacter ureolyticus clinical isolate RIGS 9880. Genome Announcements. 3(6):e01291-15.

Interpretive Summary: Campylobacter ureolyticus was initially isolated from superficial soft tissue lesions, and genital and periodontal infections. However, C. ureolyticus has been increasingly isolated from cases of human gastroenteritis, including patients with ulcerative colitis and Crohn’s disease. In some regions, C. ureolyticus has become the second most isolated Campylobacter, after Campylobacter jejuni, and is isolated also from both food (pigs, cattle) and domestic (dogs) animals. The association of this organism with serious human illness has triggered several recent studies on the virulence of C. ureolyticus. However, although partial chromosomal sequences are available for this species, a complete C. ureolyticus genome was not. This study presents the first complete C. ureolyticus genome. Multiple genes associated with pathogenicity were identified, providing possible lines of investigation into the sudden increase of virulence in this organism.

Technical Abstract: The emerging pathogen Campylobacter ureolyticus has been isolated from human and animal genital infections, human periodontal infections, domestic and food animals, and from cases of human gastroenteritis. We report the whole-genome sequence of the human clinical isolate RIGS 9880, which is the first closed genome for C. ureolyticus.