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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Endemic Poultry Viral Diseases Research » Research » Publications at this Location » Publication #358995
Research Project: Genetic and Biological Determinants of Avian Herpesviruses Pathogenicity, Transmission, and Evolution to Inform the Development of Effective Control Strategies

Location: Endemic Poultry Viral Diseases Research

Title: Research Update: Avian Disease & Oncology Lab and Endemic Poultry Viral Diseases Unit

Author
item Dunn, John
item CHENG, HANS - US Department Of Agriculture (USDA)
item HEIDARI, MOHAMMAD - US Department Of Agriculture (USDA)
item ZHANG, HUANMIN - US Department Of Agriculture (USDA)
item Kim, Taejoong
item Spatz, Stephen
item Yu, Qingzhong

Submitted to: United States Animal Health Association Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 10/18/2018
Publication Date: 10/18/2018
Citation: Dunn, J.R., Cheng, H., Heidari, M., Zhang, H., Kim, T.N., Spatz, S.J., Yu, Q. 2018. Research Update: Avian Disease & Oncology Lab and Endemic Poultry Viral Diseases Unit. Proceedings of the United States Animal Health Association Annual Meeting, October 18-24, 2018.

Interpretive Summary: The ADOL and EPVD units have three active projects on poultry genomics, enteric diseases and avian herpesviruses. Selected research highlights from the last year include 1) Discovery of Ikarus gene as important driver mutation in development of Marek’s disease (MD). 2) Determination of infectious duration of Marek’s disease virus (MDV) for developing methods to reduce virus transmission. 3) Development of Newcastle disease virus (NDV) vector vaccine. 4) Confirmation of turkey herpesvirus (HVT) vector vaccine interference and evaluation of effect of mixtures on vaccine replication. 5) Development of MDV serotype 2 vaccine vector as possible strategy for avoiding HVT interference. 6) Development of infectious laryngotracheitis (ILT) infectious clone. 7) Evaluation of new sequencing methods for infectious laryngotracheitis virus. These research efforts will aid future efforts to select birds for superior disease resistance to MD, improve diagnostic methods for ILT, and improve vaccines against MD, ILT, NDV and other poultry viruses.

Technical Abstract: The ADOL and EPVD units have three active projects on poultry genomics, enteric diseases and avian herpesviruses. Selected research highlights from the last year include 1) Discovery of Ikarus gene as important driver mutation in development of Marek’s disease (MD). 2) Determination of infectious duration of Marek’s disease virus (MDV) for developing methods to reduce virus transmission. 3) Development of Newcastle disease virus (NDV) vector vaccine. 4) Confirmation of turkey herpesvirus (HVT) vector vaccine interference and evaluation of effect of mixtures on vaccine replication. 5) Development of MDV serotype 2 vaccine vector as possible strategy for avoiding HVT interference. 6) Development of infectious laryngotracheitis (ILT) infectious clone. 7) Evaluation of new sequencing methods for infectious laryngotracheitis virus. These research efforts will aid future efforts to select birds for superior disease resistance to MD, improve diagnostic methods for ILT, and improve vaccines against MD, ILT, NDV and other poultry viruses.