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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Exotic & Emerging Avian Viral Diseases Research » Research » Publications at this Location » Publication #364912
Research Project: Intervention Strategies to Predict, Prevent and Control Disease Outbreaks Caused by Emerging Strains of Virulent Newcastle Disease Viruses

Location: Exotic & Emerging Avian Viral Diseases Research

Title: First complete genome sequence of currently circulating infectious bronchitis virus strain DMV/1639 of the GI-17 lineage

Author
item GORAICHUK, IRYNA - Consultant
item KULKARNI, ARUN - Georgia Poultry Laboratory Network
item Williams Coplin, Tina
item Suarez, David
item Afonso, Claudio

Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/31/2019
Publication Date: 8/22/2019
Citation: Goraichuk, I.V., Kulkarni, A.B., Williams Coplin, T.D., Suarez, D.L., Afonso, C.L. 2019. First complete genome sequence of currently circulating infectious bronchitis virus strain DMV/1639 of the GI-17 lineage. Microbiology Resource Announcements. 8(34):e00840-19. https://doi.org/10.1128/MRA.00840-19.
DOI: https://doi.org/10.1128/MRA.00840-19

Interpretive Summary: Infectious bronchitis virus (IBV) is the etiological agent of an acute and highly contagious disease that affects chickens of all ages. Genetic diversity in coronaviruses is due to adaptive evolution caused by high mutation rates and genetic recombination. Based on the Spike 1 protein variability, six genotypes of IBV comprising 32 distinct viral lineages have been described. Numerous IBV variants have been reported in the United States. A nephropathogenic IBV strain DMV/1639/11, isolated from Delmarva Peninsula in 2011, is a still circulating variant, that causes airsacculitis and respiratory illness in affected chickens. To date, only partial genomes of the DMV/1639 type viruses are available in public databases. In this study, we report the first isolation of this IBV variant from Georgia, USA. The obtained sequence represents the first DMV/1639 complete genome. This study provides the first complete genome sequence for this particular strain of virus. The use of sequence information is valuable for in-depth understanding of the evolution of the virus and will help the development of better diagnostic and vaccine tools the United States.

Technical Abstract: Avian infectious bronchitis virus is the causative agent of a highly contagious disease that results in severe economic losses to the poultry industry worldwide. Here, we report the first coding-complete genome sequence of strain DMV/1639 of the GI-17 lineage, isolated from broiler chickens in Georgia in 2019.