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Research Project: Intervention Strategies to Predict, Prevent and Control Disease Outbreaks Caused by Emerging Strains of Virulent Newcastle Disease Viruses

Location: Exotic & Emerging Avian Viral Diseases Research

Title: Complete genome sequences of 11 Newcastle disease virus isolates of sub-genotype VII.2 from Indonesia

Author
item GORAICHUK, IRYNA - Consultant
item Williams Coplin, Tina
item WIBOWO, MICHAEL - Gadjah Mada University
item DURR, PETER - Csiro Australian Animal Health Laboratory
item ASMARA, WIDYA - Gadjah Mada University
item ARTANTO, SIDNA - Gadjah Mada University
item DIMITROV, KIRIL - Consultant
item Afonso, Claudio
item Suarez, David

Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/8/2020
Publication Date: 1/30/2020
Citation: Goraichuk, I.V., Williams Coplin, T.D., Wibowo, M.H., Durr, P.A., Asmara, W., Artanto, S., Dimitrov, K.M., Afonso, C.L., Suarez, D.L. 2020. Complete genome sequences of 11 Newcastle disease virus isolates of sub-genotype VII.2 from Indonesia. Microbiology Resource Announcements. 09(5):e01519-19. https://doi.org/10.1128/MRA.01519-19.
DOI: https://doi.org/10.1128/MRA.01519-19

Interpretive Summary: Newcastle disease virus (NDV) is a deadly disease of poultry that is commonly found in Mexico, Central America, South America, Africa, and Asia. Some strains are more virulent than other strains, and it has become common to sequence NDV isolates as a way to characterize them. In an effort to characterize viruses from Indonesia, sequence analysis was performed on the complete genome of viruses. In this study, we report the complete genomes of 11 virulent NDVs of the sub-genotype VII.2 isolated from vaccinated chickens in Indonesia. The use of sequence information is valuable as it provides evidence that virulent strains were circulating among vaccinated flocks in three different provinces of Indonesia in 2013-2014. This type of information helps prepare the United States for future potential outbreaks.

Technical Abstract: We report the complete genome sequences of 11 virulent Newcastle disease viruses. The isolates were obtained from vaccinated broiler and layer chickens in three different provinces of Indonesia in 2013 and 2014. Phylogenetic analysis revealed that all isolates belong to subgenotype VII.2 in the class II cluster.