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Research Project: Intervention Strategies to Control and Eradicate Foreign Animal Diseases of Swine

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Title: Structural predictions of the complete ASFV-G proteome

Author
item Spinard Iii, Edward
item Azzinaro, Paul
item RAI, AYUSHI - Oak Ridge Institute For Science And Education (ORISE)
item Espinoza, Nallely
item Ramirez-Medina, Elizabeth
item Borca, Manuel
item Gladue, Douglas

Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/6/2022
Publication Date: 11/21/2022
Citation: Spinard III, E.J., Azzinaro, P.A., Rai, A., Espinoza, N.N., Ramirez Medina, E., Borca, M.V., Gladue, D.P. 2022. Structural predictions of the complete ASFV-G proteome. Microbiology Resource Announcements. 11(12):e0088122. https://doi.org/10.1128/mra.00881-22.
DOI: https://doi.org/10.1128/mra.00881-22

Interpretive Summary: African swine fever virus (ASFV) causes a devastating disease in swine, called African swine fever (ASF), that is currently spreading across Europe, Asia and recently appeared in the Americas. The structure and function of most of the 190 genes in ASFV is unknown. Here we predicted all ASFV genes and are announcing there availability to ASF researchers worldwide.

Technical Abstract: African swine fever virus (ASFV) causes a lethal disease (ASF) in domestic pigs. ASF is currently producing a pandemic affecting pig production across Eurasia producing a shortage of food accessibility. ASFV is structurally complex, harboring a large genome encoding over 190 genes. AlphaFold was determined to demonstrate protein structure accuracy completive to experimentally resolved structures. Accordingly, the structures of all 193 proteins predicted to be encoded by the progenitor strain from the most recent outbreak, ASFV Georgia 2007 (ASFV-G) (GenBank Accession FR682468), were determined by AlphaFold . Utilizing the U.S. Department of Agriculture's (USDA) Agricultural Research Service (ARS) Scientific Computing Initiative (SCINet) Ceres HPC cluster or the SCINet/Mississippi State University (MSU) collaborative Atlas HPC cluster, this prediction of all the ASFV proteins structure was possible, here we provide this information to the ASF research community.