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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Food Safety and Enteric Pathogens Research » Research » Publications at this Location » Publication #409442
Research Project: Intestinal Microbial Ecology and Non-Antibiotic Strategies to Limit Shiga Toxin-Producing Escherichia coli (STEC) and Antimicrobial Resistance Transmission in Food Animals

Location: Food Safety and Enteric Pathogens Research

Title: From snoot to tail - A brief review of influenza virus infection and immunity in pigs

Author
item MA, WENJUN - University Of Missouri
item Loving, Crystal
item DRIVER, JOHN - University Of Missouri

Submitted to: Journal of Immunology
Publication Type: Review Article
Publication Acceptance Date: 7/7/2023
Publication Date: 10/25/2023
Citation: Ma, W., Loving, C.L., Driver, J.P. 2023. From snoot to tail - A brief review of influenza virus infection and immunity in pigs. Journal of Immunology. https://doi.org/10.4049/jimmunol.2300385.
DOI: https://doi.org/10.4049/jimmunol.2300385

Interpretive Summary:

Technical Abstract: Pigs play an important role in influenza A virus (IAV) epidemiology as they support replication of human, avian, and swine origin viruses and act as an IAV reservoir for pigs and other species, including humans. Moreover, novel IAVs with human pandemic potential may be generated in pigs. To minimize the threat of IAVs on human and swine health, it is crucial to understand host defense mechanisms that restrict viral replication and pathology in pigs. Here, we review IAV strains circulating in the North American swine population, as well as porcine innate and acquired immune responses to IAV, including recent advances achieved through immunological tools developed specifically for swine. Furthermore, we highlight unique aspects of the porcine pulmonary immune system, which warrant consideration when developing vaccines and therapeutics to limit IAV in swine or when using pigs to model human IAV infections.