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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Ruminant Diseases and Immunology Research » Research » Publications at this Location » Publication #416296
Research Project: Genomic and Mitigation Strategies to Control Mastitis

Location: Ruminant Diseases and Immunology Research

Title: Future of immune modulation in animal agriculture

Author
item MCGILL, JODI - Iowa State University
item Loving, Crystal
item KEHRLI, MARCUS - Retired ARS Employee

Submitted to: Annual Review of Animal Biosciences
Publication Type: Literature Review
Publication Acceptance Date: 6/30/2024
Publication Date: 8/19/2024
Citation: Mcgill, J.L., Loving, C.L., Kehrli, M.E. 2024. Future of immune modulation in animal agriculture. Annual Review of Animal Biosciences. 13. https://doi.org/10.1146/annurev-animal-111523-102209.
DOI: https://doi.org/10.1146/annurev-animal-111523-102209

Interpretive Summary:

Technical Abstract: Immune modulation in animal agriculture has been of research interest for several decades, yet only a few immune modulators have received regulatory approval in the United States and around the world. In this review we summarize market and regulatory environments impacting commercial development of immune modulators for use in livestock and poultry. In the United States, very few immune modulators have received regulatory approval for use in livestock by either the USDA-Center for Veterinary Biologics or the Food and Drug Administration. To date, only one immunomodulator has received FDA approval and an extensive body of peer-reviewed literature is available regarding the basis for its use and health benefits. We present a more thorough review of the history and impact of this immune restorative. Finally, the interaction of immune modulators on health, metabolism and other factors impacting the future of immune modulation in livestock is discussed.