Author
![]() |
Smith, Timothy - Tim |
![]() |
KAMBADUR, RAVI - AGRESEARCH, NEW ZEALAND |
![]() |
SHARMA, MRIDULA - AGRESEARCH, NEW ZEALAND |
![]() |
Sonstegard, Tad |
![]() |
Lopez, Nestor |
![]() |
Kappes, Steven - Steve |
![]() |
Casas, Eduardo |
![]() |
Stone, Roger |
![]() |
Keele, John |
![]() |
Fahrenkrug, Scott |
Submitted to: Meeting Abstract
Publication Type: Proceedings Publication Acceptance Date: 10/27/1997 Publication Date: N/A Citation: N/A Interpretive Summary: Technical Abstract: A partially recessive locus (mh) causes a heritable syndrome of generalized muscular hypertrophy in cattle, a result of cellular hyperplasia. The mh locus is mapped to an interval on bovine chromosome 2 (BTA2) between the COL3A1 and PROC genes in both Belgian Blue and Piedmontese breeds, suggesting the same locus is responsible in this breed. We show that myostatin, a member of the TGF-beta gene family, maps to the same interval, making it a positional candidate gene for mh. RT-PCR analysis shows that myostatin is present at approximately normal levels at the RNA level in Belgian Blue embryos. However, mutation analysis shows that each breed has a distinct mutation in the coding portion of the cDNA that is predicted to interfere with the function of the gene. |