Research Project: Microbiota and Nutritional Health

Location: Children's Nutrition Research Center

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Expert review of child and caregiver critiques of a therapeutic guided imagery therapy mobile application targeting disorders of gut-brain interaction in children - (Peer Reviewed Journal)
Hollier, J.M., Strickland, T.A., Fordis, C.M., Shulman, R.J., Thompson, D.J. 2024. Expert review of child and caregiver critiques of a therapeutic guided imagery therapy mobile application targeting disorders of gut-brain interaction in children. Digital Health. https://doi.org/10.1177/20552076241245376.

Avoidant/restrictive food intake disorder prevalence is high in children with gastroparesis and functional dyspepsia - (Peer Reviewed Journal)
Kaul, I., Burton-Murray, H., Musaad, S., Mirabile, Y., Czyzewski, D., Van Tilburg, M.A., Sher, A.C., Chumpitazi, B.P., Shulman, R.J. 2024. Avoidant/restrictive food intake disorder prevalence is high in children with gastroparesis and functional dyspepsia. Neurogastroenterology & Motility. 36(5). Article e14777. https://doi.org/10.1111/nmo.14777.

Feasibility and acceptability of a supplementary food with added fish oil and choline for undernourished pregnant women in Sierra Leone - (Peer Reviewed Journal)
Koroma, A.S., Gustafson, B., Kohlen, C., Moore, M., Ngegbai, S., Kleban, E., Wegner, D.R., Kidd, P., Stephenson, K.B., Li, Y.N., Brenna, J.T., Manary, M.J. 2024. Feasibility and acceptability of a supplementary food with added fish oil and choline for undernourished pregnant women in Sierra Leone. African Journal of Food, Agriculture, Nutrition and Development. 24(4):26072-26093. https://doi.org/10.18697/ajfand.129.24480.

The effect of breastfeeding practices of undernourished mothers in rural Sierra Leone on infant growth and mortality - (Peer Reviewed Journal)
Koroma, A.S., Stephenson, K.B., Iversen, P.O., Manary, M.J., Hendrixson, D.T. 2024. The effect of breastfeeding practices of undernourished mothers in rural Sierra Leone on infant growth and mortality. Children. 11(2). Article 233. https://doi.org/10.3390/children11020233.

Single cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis - (Peer Reviewed Journal)
Chikkamenahalli, L.L., Jessen, E., Bernard, C.E., Ip, W., Breen-Lyles, M., Cipriani, G., Pullapantula, S.R., Li, Y., Alasfoor, S., Wilson, L., Koch, K.L., Kuo, B., Shulman, R.J., Chumpitazi, B.P., McKenzie, T.J., Kellogg, T.A., Tonascia, J., Hamilton, F.A., Sarosiek, I., McCallum, R., Parkman, H.P., Pasricha, P.J., Abell, T.L., Farrugia, G., Dasari, S., Grover, M. 2024. Single cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis. iScience. 27(3). Article 108991. https://doi.org/10.1016/j.isci.2024.108991.

Leptin reduction as a required component for weight loss - (Peer Reviewed Journal)
Zhao, S., Li, N., Xiong, W., Li, G., He, S., Zhang, Z., Zhu, Q., Jiang, N., Ikejiofor, C., Zhu, Y., Wang, M., Han, X., Zhang, N., Solis-Herrera, C., Kusminski, C., An, Z., Elmquist, J.K., Scherer, P.E. 2024. Leptin reduction as a required component for weight loss. Diabetes. 73(2):197-210. https://doi.org/10.2337/db23-0571.

Urine and dried blood spots from children and pregnant women reveal phytochemicals, amino acids, and carnitine metabolites as cowpea consumption biomarkers - (Peer Reviewed Journal)
Tipton, M., Baxter, B.A., Pfluger, B.A., Sayre-Chavez, B., Muñoz-Amatriaín, M., Broeckling, C.D., Shani, I., Steiner-Asiedu, M., Manary, M., Ryan, E.P. 2024. Urine and dried blood spots from children and pregnant women reveal phytochemicals, amino acids, and carnitine metabolites as cowpea consumption biomarkers. Molecular Nutrition and Food Research. 68(4). Article e2300222. https://doi.org/10.1002/mnfr.202300222.

Hyperleptinemia contributes to antipsychotic drug–associated obesity and metabolic disorders - (Peer Reviewed Journal)
Zhao, S., Lin, Q., Xiong, W., Li, L., Straub, L., Zhang, D., Zapata, R., Zhu, Q., Sun, X., Zhang, Z., Funcke, J., Li, C., Chen, S., Zhu, Y., Jiang, N., Li, G., Xu, Z., Wyler, S.C., Wang, M., Juli, B., Han, X., Kusminski, C.M., Zhang, Z., An, Z., Elmquist, J.K., Osborn, O., Liu, C., Scherer, P.E. 2023. Hyperleptinemia contributes to antipsychotic drug–associated obesity and metabolic disorders. Science Translational Medicine. 15. Article 723. https://doi.org/10.1126/scitranslmed.ade8460.

Qa-SNARE syntaxin 18 mediates lipid droplet fusion with SNAP23 and SEC22B - (Peer Reviewed Journal)
Fu, Y., Ding, B., Liu, X., Zhao, S., Chen, F., Li, L., Zhu, Y., Yuan, Z., Shen, Y., Yang, C., Zhao, J., Shao, M., Chen, S., Bickel, P.E., Zhong, Q. 2023. Qa-SNARE syntaxin 18 mediates lipid droplet fusion with SNAP23 and SEC22B. Cell Discovery. 9. Article 115. https://doi.org/10.1038/s41421-023-00613-4.

Sex-dependent efficacy of dietary fiber in pediatric functional abdominal pain - (Peer Reviewed Journal)
So, S., Badu, S., Wu, Q., Yalcinkaya, N., Mirabile, Y., Castaneda, R., Musaad, S., Heitkemper, M., Savidge, T.C., Shulman, R.J. 2023. Sex-dependent efficacy of dietary fiber in pediatric functional abdominal pain. Gastroenterology. 166(4):645-657. https://doi.org/10.1053/j.gastro.2023.12.011.

Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson's disease - (Review Article)
Wooton-Kee, C. 2023. Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson's disease. Pharmacology and Therapeutics. 251. Article 108529. https://doi.org/10.1016/j.pharmthera.2023.108529.

Factors associated with adherence to a low fermentable carbohydrate diet in children with functional gastrointestinal disorders - (Peer Reviewed Journal)
Tenenbaum, R.B., Czyzewski, D., McMeans, A., Narayana, V., Chumpitazi, B.P., Levy, R.L., Shulman, R.J., Musaad, S., Mirabile, Y.Z., Self, M. 2023. Factors associated with adherence to a low fermentable carbohydrate diet in children with functional gastrointestinal disorders. Journal of the Academy of Nutrition and Dietetics. https://doi.org/10.1016/j.jand.2023.09.001.

Dimethyl sulfoxide inhibits bile acid synthesis in healthy mice but does not protect mice from bile-acid-induced liver damage - (Peer Reviewed Journal)
Chen, X., Li, H., Liu, Y., Qi, J., Dong, B., Huang, S., Zhao, S., Zhu, Y. 2023. Dimethyl sulfoxide inhibits bile acid synthesis in healthy mice but does not protect mice from bile-acid-induced liver damage. Biology. 12(8). Article 1105. https://doi.org/10.3390/biology12081105.

Relationships among intragastric meal distribution during gastric emptying scintigraphy, water consumption during water load satiety testing, and symptoms of gastroparesis - (Peer Reviewed Journal)
Parkman, H.P., Wilson, L.A., Silver, P., Maurer, A.H., Sarosiek, I., Bulat, R.S., Kuo, B., Grover, M., Farrugia, G., Chumpitazi, B.P., Shulman, R.J., Malik, Z., Miriel, L.A., Tonascia, J., Hamilton, F., Abell, T.L., Pasricha, P.J., McCallum, R.W., Koch, K.L. 2023. Relationships among intragastric meal distribution during gastric emptying scintigraphy, water consumption during water load satiety testing, and symptoms of gastroparesis. American Journal of Physiology - Gastrointestinal and Liver Physiology. 325(5):G407-417. https://doi.org/10.1152/ajpgi.00065.2023.

Many pediatric patients with gastroparesis do not receive dietary education - (Peer Reviewed Journal)
Eseonu, D., Dongarwar, D., Salihu, H., Chumpitazi, B.P., Shulman, R.J. 2023. Many pediatric patients with gastroparesis do not receive dietary education. BioMed Central (BMC) Gastroenterology. 23. Article 240. https://doi.org/10.1186/s12876-023-02865-6.

A pilot genome-wide association study meta-analysis of gastroparesis - (Peer Reviewed Journal)
Tavares, L.C., Zheng, T., Kwicklis, M., Mitchell, E., Pandit, A., Pullapantula, S., Bernard, C., Teder-Laving, M., Marques, F.Z., Esko, T., Kuo, B., Shulman, R.J., Chumpitazi, B.P., Koch, K.L., Sarosiek, I., Abell, T.L., McCallum, R.W., Parkman, H.P., Pasricha, P.J., Hamilton, F.A., Tonascia, J., Zawistowski, M., Farrugia, G., Grover, M., D'Amato, M. 2023. A pilot genome-wide association study meta-analysis of gastroparesis. United European Gastroenterology Journal. 11(8):784-796. https://doi.org/10.1002/ueg2.12453.

Women's empowerment and child nutrition in a context of shifting livelihoods in Eastern Oromia, Ethiopia - (Peer Reviewed Journal)
Mechlowitz, K., Singh, N., Li, X., Chen, D., Yang, Y., Rabil, A., Cheraso, A.J., Ahmed, I.A., Amin, J.K., Gebreyes, W.A., Hassen, J.Y., Ibrahim, A.M., Manary, M.J., Rajashekara, G., Roba, K.T., Usmane, I.A., Havelaar, A.H., McKune, S.L. 2023. Women's empowerment and child nutrition in a context of shifting livelihoods in Eastern Oromia, Ethiopia. Frontiers in Nutrition. 10. Article 1048532. https://doi.org/10.3389/fnut.2023.1048532.

Prevalence and load of the campylobacter genus in infants and associated household contacts in rural eastern Ethiopia: A longitudinal study from the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) project - (Peer Reviewed Journal)
Deblais, L., Ojeda, A., Brhane, M., Mummed, B., Hassen, K.A., Ahmedo, B.U., Weldesenbet, Y.D., Amin, J.K., Ahmed, I.A., Usmane, I.A., Yusuf, E.A., Seran, A.J., Abrahim, F.I., Game, H.T., Mummed, B.A., Usmail, M.M., Umer, K.A., Dawid, M.M., Gebreyes, W., French, N., Hassen, J.Y., Roba, K.T., Mohammed, A., Yimer, G., Saleem, C., Chen, D., Singh, N., Manary, M.J., McKune, S.L., Havelaar, A., Rajashekara, G. 2023. Prevalence and load of the campylobacter genus in infants and associated household contacts in rural eastern Ethiopia: A longitudinal study from the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) project. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.00424-23.

Rationale and design of a pilot randomized controlled trial to increase moderate-to-vigorous physical activity in preadolescent Latina girls and their mothers - (Peer Reviewed Journal)
Arredondo, E.M., Schneider, J., Torres-Ruiz, M., Telles, V., Thralls-Butte, K., West, M., Maldonado, M., Gallagher, K., Roesch, S., Ayala, G.X., Baranowski, T. 2023. Rationale and design of a pilot randomized controlled trial to increase moderate-to-vigorous physical activity in preadolescent Latina girls and their mothers. Contemporary Clinical Trials Communications. 33. Article 101137. https://doi.org/10.1016/j.conctc.2023.101137.

Gastrointestinal symptoms profile in gastroparesis compared to other functional and organic gastrointestinal diseases - (Peer Reviewed Journal)
Varni, J.W., Chumpitazi, B.P., Febo-Rodriguez, L., Shulman, R.J. 2023. Gastrointestinal symptoms profile in gastroparesis compared to other functional and organic gastrointestinal diseases. Journal of Pediatric Gastroenterology and Nutrition. 77(1):e1-e7. https://doi.org/10.1097/MPG.0000000000003806.

Age differences in core symptoms and symptom relationships in patients with irritable bowel syndrome: A network analysis - (Peer Reviewed Journal)
Yang, P., Kamp, K.J., Burr, R.L., Tang, H., Dobra, A., Shulman, R.J., Heitkemper, M.M. 2023. Age differences in core symptoms and symptom relationships in patients with irritable bowel syndrome: A network analysis. American Journal of Gastroenterology. https://doi.org/10.14309/ajg.0000000000002280.

Children's and adolescents' rising animal-source food intakes in 1990–2018 were impacted by age, region, parental education and urbanicity - (Peer Reviewed Journal)
Miller, V., Webb, P., Cudhea, F., Zhang, J., Reedy, J., Shi, P., Erndt-Marino, J., Coates, J., Micha, R., Mozaffarian, D., & Global Dietary Database. 2023. Children's and adolescents' rising animal-source food intakes in 1990–2018 were impacted by age, region, parental education and urbanicity. Nature Food. 4:305-319. https://doi.org/10.1038/s43016-023-00731-y.

Is there enough choline for children in food aid? - (Other)
May, T., Caudill, M., Manary, M.J. 2023. Is there enough choline for children in food aid?. JAMA Pediatrics. 177:223-224. https://doi.org/10.1001/jamapediatrics.2022.5543.

Editorial for the MCE special issue on "FXR and metabolism" - (Other)
Kim, K.H., Wooton-Kee, C.R. 2023. Editorial for the MCE special issue on "FXR and metabolism". Molecular and Cellular Endocrinology. 565. Article 111889. https://doi.org/10.1016/j.mce.2023.111889.

Exploration of associations among dietary tryptophan, microbiome composition and function, and symptom severity in irritable bowel syndrome - (Peer Reviewed Journal)
Plantinga, A.M., Kamp, K.J., Wu, Q., Chen, L., Yoo, L., Burr, R.L., Cain, K.C., Raftery, D., Neto, F.C., Badu, S., So, S., Savidge, T., Shulman, R.J., Heitkemper, M.M. 2023. Exploration of associations among dietary tryptophan, microbiome composition and function, and symptom severity in irritable bowel syndrome. Neurogastroenterology & Motility. 35. Article e14545. https://doi.org/10.1111/nmo.14545.

Docosahexaenoic acid stability in ready-to-use therapeutic food - (Peer Reviewed Journal)
James, J., Stephenson, K., Callaghan-Gillespie, M., Kamara, M.T., Park, H.G., Brenna, J.T., Manary, M.J. 2023. Docosahexaenoic acid stability in ready-to-use therapeutic food. Foods. 12(2). Article 308. https://doi.org/10.3390/foods12020308.

Characteristics and outcomes of patients with gastroparesis using enteral and/or exclusive parenteral nutrition - (Peer Reviewed Journal)
Parkman, H.P., Blackford, A.L., Murray, H., Yates, K.P., Grover, M., Malik, Z., Schey, R., Bulat, R.S., Koch, K.L., Sarosiek, I., Kuo, B., Shulman, R.J., Chumpitazi, B.P., Farrugia, G., Miriel, L., Tonascia, J., Hamilton, F., Pasricha, P.J., McCallum, R.W., Abell, T.L. 2023. Characteristics and outcomes of patients with gastroparesis using enteral and/or exclusive parenteral nutrition. Journal of Parenteral and Enteral Nutrition. 47(4):541-549. https://doi.org/10.1002/jpen.2493.

Socioecological predictors of breastfeeding practices in rural eastern Ethiopia - (Peer Reviewed Journal)
Magalhaes, M., Ojeda, A., Mechlowitz, K., Brittain, K., Daniel, J., Roba, K.T., Hassen, J.Y., Manary, M.J., Gebreyes, W.A., Havelaar, A.H., McKune, S.L. 2022. Socioecological predictors of breastfeeding practices in rural eastern Ethiopia. International Breastfeeding Journal. 17. Article 93. https://doi.org/10.1186/s13006-022-00531-3.

An alternative oat-containing, ready-to-use, therapeutic food does not alter intestinal permeability or the 16S ribosomal RNA fecal microbiome configuration among children with severe malnutrition in Sierra Leone: A RCT - (Peer Reviewed Journal)
Hendrixson, D., Naskidashvili, N., Stephenson, K.B., Laury, M.L., Koroma, A.S., Manary, M.J. 2022. An alternative oat-containing, ready-to-use, therapeutic food does not alter intestinal permeability or the 16S ribosomal RNA fecal microbiome configuration among children with severe malnutrition in Sierra Leone: A Randomized Controlled Trial. Journal of Nutrition. 152:2744-2753. https://doi.org/10.1093/jn/nxac207.

Supplementary feeding and infection control in pregnant adolescents - A secondary analysis of a randomized trial among malnourished women in Sierra Leone - (Peer Reviewed Journal)
Koroma, A.S., Ellie, M., Bangura, K., Iversen, P.O., Hendrixson, D.T., Stephenson, K., Manary, M.J. 2022. Supplementary feeding and infection control in pregnant adolescents - A secondary analysis of a randomized trial among malnourished women in Sierra Leone. Maternal and Child Nutrition. 19(1). Article e13456. https://doi.org/10.1111/mcn.13456.

Infant behavioral state and stool microbiome in infants receiving Lactocaseibacillus rhamnosus GG in formula: Randomized controlled trial - (Peer Reviewed Journal)
Shulman, R.J., Chichlowwski, M., Gutierrez Orozco, F., Harris, C.L., Wampler, J.L., Bokulich, N.A., Berseth, C.L. 2022. Infant behavioral state and stool microbiome in infants receiving Lactocaseibacillus rhamnosus GG in formula: Randomized controlled trial. BMC Pediatrics. 22. Article 580. https://doi.org/10.1186/s12887-022-03647-x.

Unravelling the reservoirs for colonisation of infants with Campylobacter spp. in rural Ethiopia: Protocol for longitudinal study during a global pandemic and political tensions - (Peer Reviewed Journal)
Havelaar, A.H., Brhane, M., Ahmed, I.A., Kedir, J., Chen, D., Deblais, L., French, N., Gebreyes, W.A., Hassen, J.Y., Li, X., Manary, M.J., Mekuria, Z., Ibrahim, A.M., Mummed, B., Ojeda, A., Rajashekara, G., Roba, K.T., Saleem, C., Singh, N., Usmane, I.A., Yang, Y., Yimer, G., McKune, S. 2022. Unravelling the reservoirs for colonisation of infants with Campylobacter spp. in rural Ethiopia: Protocol for longitudinal study during a global pandemic and political tensions. BMJ Open. 12(10). Article e061311. https://doi.org/10.1136/bmjopen-2022-061311.

Newborn mid–upper arm circumference identifies low–birth weight and vulnerable infants: A secondary analysis - (Peer Reviewed Journal)
Hendrixson, D.T., Lasowski, P.N., Koroma, A.S., Manary, M.J. 2022. Newborn mid–upper arm circumference identifies low–birth weight and vulnerable infants: A secondary analysis. Current Developments in Nutrition. 6(10). Article nzac138. https://doi.org/10.1093/cdn/nzac138.

Adipocyte mesenchymal transition contributes to mammary tumor progression - (Peer Reviewed Journal)
Zhu, Q., Zhu, Y., Hepler, C., Zhang, Q., Park, J., Gliniak, C., Henry, G.H., Crewe, C., Bu, D., Zhang, Z., Zhao, S., Morley, T., Li, N., Kim, D., Strand, D., Deng, Y., Robino, J.J., Varlamov, O., Gordillo, R., Kolonin, M.G., Kusminski, C.M., Gupta, R.K., Scherer, P.E. 2022. Adipocyte mesenchymal transition contributes to mammary tumor progression. Cell Reports. 40(11). Article 111362. https://doi.org/10.1016/j.celrep.2022.111362.

Global dietary quality in 185 countries from 1990 to 2018 show wide differences by nation, age, education, and urbanicity - (Peer Reviewed Journal)
Miller, V., Webb, P., Cudhea, F., Shi, P., Zhang, J., Reedy, J., Erndt-Marino, J., Coates, J., Mozaffarian, D., Global Dietary Database. 2022. Global dietary quality in 185 countries from 1990 to 2018 show wide differences by nation, age, education, and urbanicity. Nature Food. 3:694–702. https://doi.org/10.1038/s43016-022-00594-9.

Maternal adipocyte connexin43 gap junctions affect breastmilk lactose levels and neonate growth in mice - (Peer Reviewed Journal)
Huang, M., Song, A., Chen, X., Ishtiaq, S., Wang, C., Hadsell, D.L., Wang, Q.A., Zhu, Y. 2022. Maternal adipocyte connexin43 gap junctions affect breastmilk lactose levels and neonate growth in mice. Biology. 11(7). Article 1023. https://doi.org/10.3390/biology11071023.

Management of moderate acute malnutrition in children in resource-limited countries - (Book / Chapter)
Trehan, I., Manary, M.J. 2022. Management of moderate acute malnutrition in children in resource-limited countries. In UpToDate. Available at: https://www.uptodate.com/contents/management-of-moderate-acute-malnutrition-in-children-in-resource-limited-countries

Enhancing untargeted metabolomics using metadata-based source annotation - (Peer Reviewed Journal)
Gauglitz, J.M., West, K.A., Bittremieux, W., Williams, C.L., Weldon, K.C., Panitchpakdi, M., Di Ottavio, F., Aceves, C.M., Brown, E., Sikora, N.C., Jarmusch, A.K., Martino, C., Tripathi, A., Meehan, M.J., Dorrestein, K., Shaffer, J.P., Coras, R., Vargas, F., Deright Goldasich, L., Schwartz, T., Bryant, M., Humphrey, G., Johnson, A.J., Spengler, K., Belda-Ferre, P., Diaz, E., McDonald, D., Zhu, Q., Elijah, E., Wang, M., Marotz, C., Sprecher, K.E., Vargas-Robles, D., Withrow, D., Ackerman, G., Herrera, L., Bradford, B., Mauriz Marques, L., Geraldo Amaral, J., Moreira Silva, R., Protasio Veras, F., Mattar Cunha, T., Donizeti Ribiero Ol, R., Louzada-Junior, P., Mills, R.H., Piotrowski, P.K., Servetas, S.L., Da Silva, S.M., Jones, C.M., Lin, N.J., Lippa, K.A., Jackson, S.A., Kaddurah Daouk, R., Galasko, D., Dulai, P.S., Kalashnikova, T., Wittenberg, C., Terkeltaub, R., Doty, M.M., Kim, J.H., Rhee, K.E., Beauchamp-Walters, J., Wright, K.P., Dominguez-Bello, M.G., Manary, M., Oliveira, M.F., Boland, B.S., Peporine Lopes, N., Guma, M., Swafford, A.D., Dutton, R.J., Knight, R., Dorreistein, P.C. 2022. Enhancing untargeted metabolomics using metadata-based source annotation. Nature Biotechnology. 40.1774–1779. https://doi.org/10.1038/s41587-022-01368-1.

Postprandial symptoms in patients with symptoms of gastroparesis roles of gastric emptying and accommodation - (Peer Reviewed Journal)
Parkman, H.P., Van Natta, M.L., Maurer, A.H., Koch, K.L., Grover, M., Malik, Z., Sarosiek, I., Abell, T.L., Bulat, R., Kuo, B., Shulman, R.J., Farrugia, G., Miriel, L., Tonascia, J., Hamilton, F., Pasricha, P.J., McCallum, R.W. 2022. Postprandial symptoms in patients with symptoms of gastroparesis roles of gastric emptying and accommodation. American Journal of Physiology - Gastrointestinal and Liver Physiology. 323:G44-G59. https://doi.org/10.1152/ajpgi.00278.2021.

Children with functional abdominal pain disorders successfully decrease FODMAP food intake on a low FODMAP diet with modest improvements in nutritional intake and diet quality - (Peer Reviewed Journal)
Narayana, V., McMeans, A.R., Levy, R.L., Shulman, R.J., Chumpitazi, B.P. 2022. Children with functional abdominal pain disorders successfully decrease FODMAP food intake on a low FODMAP diet with modest improvements in nutritional intake and diet quality. Neurogastroenterology & Motility. https://doi.org/10.1111/nmo.14392.

Gastrointestinal symptoms profile in pediatric patients with gastroparesis compared to healthy controls - (Peer Reviewed Journal)
Febo-Rodriguez, L., Chumpitazi, B.P., Musaad, S., Sher, A.C., Varni, J.W., Shulman, R.J. 2022. Gastrointestinal symptoms profile in pediatric patients with gastroparesis compared to healthy controls. Journal of Pediatric Gastroenterology and Nutrition. https://doi.org/10.1097/MPG.0000000000003484.

For good measure: Near-birth anthropometry predicts neonatal and infant mortality - (Other)
Stephenson, K.B., Hendrixson, D.T., Manary, M.J. 2022. For good measure: Near-birth anthropometry predicts neonatal and infant mortality. American Journal of Clinical Nutrition. 115(5):1259-1260. https://doi.org/10.1093/ajcn/nqac042.

Effect of liquid and solid test meals on symptoms and gastric myoelectrical activity in patients with gastroparesis and functional dyspepsia - (Peer Reviewed Journal)
Koch, K.L., Van Natta, M., Parkman, H.P., Grover, M., Abell, T.L., McCallum, R.W., Shaltout, H.A., Sarosiek, I., Farrugia, G., Shulman, R.J., Tonascia, J., Miriel, L., Hamilton, F., Pasricha, P.J. 2022. Effect of liquid and solid test meals on symptoms and gastric myoelectrical activity in patients with gastroparesis and functional dyspepsia. Neurogastroenterology & Motility. https://doi.org/10.1111/nmo.14376.

Progress in gastroparesis - A narrative review of the work of the gastroparesis clinical research consortium - (Review Article)
Pasricha, P.J., Grover, M., Yates, K.P., Abell, T.L., Koch, K.L., Mccallum, R.W., Sarosiek, I., Bernard, C.E., Kuo, B., Bulat, R., Shulman, R., Chumpitazi, B.P., Tonascia, J., Miriel, L.A., Wilson, L.A., Van Natta, M.L., Mitchell, E., Hamilton, F., Farrugia, G., Parkman, H.P. 2022. Progress in gastroparesis - A narrative review of the work of the gastroparesis clinical research consortium. Clinical Gastroenterology and Hepatology. 20(12):2684-2695.e3. https://doi.org/10.1016/j.cgh.2022.05.022.

Non-targeted metabolomics of cooked cowpea (Vigna unguiculate) and pigeon pea (Cajanus cajan) from Ghana using two distinct and complementary platforms - (Peer Reviewed Journal)
Sayre-Chavez, B., Baxter, B., Broeckling, C.D., Munoz-Amatriain, M., Manary, M., Ryan, E.P. 2022. Non-targeted metabolomics of cooked cowpea (Vigna unguiculate) and pigeon pea (Cajanus cajan) from Ghana using two distinct and complementary platforms. Food Chemistry: Molecular Sciences. 4. Article 100087. https://doi.org/10.1016/j.fochms.2022.100087.

Gap junction-dependent and -independent functions of connexin43 in biology - (Review Article)
Zhu, Y. 2022. Gap junction-dependent and -independent functions of connexin43 in biology. Biology. 11(2):283. https://doi.org/10.3390/biology11020283.

Activating connexin43 gap junctions primes adipose tissue for therapeutic intervention - (Peer Reviewed Journal)
Zhu, Y., Li, N., Huang, M., Chen, X., An, Y.A., Li, J., Zhao, S., Funcke, J., Cao, J., He, Z., Zhu, Q., Zhang, Z., Wang, Z.V., Xu, L., Williams, K.W., Li, C., Grove, K., Scherer, P.E. 2022. Activating connexin43 gap junctions primes adipose tissue for therapeutic intervention. Acta Pharmaceutica Sinica B. 12(7):3063-3072. https://doi.org/10.1016/j.apsb.2022.02.020.

Pediatric Rome IV diagnosis agreement is greater than agreement on diagnostic testing - (Peer Reviewed Journal)
Kaul, I., Staggs, V.S., Bagherian, A., Ali, A., Shulman, R.J., Colombo, J.M., Schurman, J.V., Chumpitazi, B.P., Friesen, C.A. 2022. Pediatric Rome IV diagnosis agreement is greater than agreement on diagnostic testing. Neurogastroenterology & Motility. https://doi.org/10.1111/nmo.14355.

Assessing infant cognition in field settings using eye-tracking: A pilot cohort trial in Sierra Leone - (Peer Reviewed Journal)
Leppanen, J.M., Butcher, J.W., Godbout, C., Stephenson, K., Hendrixson, D., Griswold, S., Rogers, B.L., Webb, P., Koroma, A.S., Manary, M.J. 2022. Assessing infant cognition in field settings using eye-tracking: A pilot cohort trial in Sierra Leone. BMJ Open. 12. Article e049783. https://doi.org/10.1136/bmjopen-2021-049783.

Supplementary feeding of moderately wasted children in Sierra Leone reduces severe acute malnutrition and death when compared with nutrition counseling: A retrospective cohort study - (Peer Reviewed Journal)
Rajabi, T., Schell, S.K., Agapova, S.E., Hassa, A., Zalta, M., Wegner, D.R., Callaghan-Gillespie, M., Koroma, A., Kamara, M.T., Manary, M.J., Stephenson, K.B. 2022. Supplementary feeding of moderately wasted children in Sierra Leone reduces severe acute malnutrition and death when compared with nutrition counseling: A retrospective cohort study. Journal of Nutrition. 152(4):1149-1158. https://doi.org/10.1093/jn/nxab451.

Peppermint oil effects on the gut microbiome in children with functional abdominal pain - (Peer Reviewed Journal)
Thapa, S., Luna, R., Chumpitazi, B.P., Oezguen, N., Abdel-Rahman, S.M., Garg, U., Musaad, S., Versalovic, J., Kearns, G.L., Shulman, R.J. 2022. Peppermint oil effects on the gut microbiome in children with functional abdominal pain. Clinical and Translational science. 15:1036-1049. https://doi.org/10.1111/cts.13224.

One-carbon metabolism in children with marasmus and kwashiorkor - (Peer Reviewed Journal)
May, T., De La Haye, B., Nord, G., Klatt, K., Stephenson, K., Adams, S., Bollinger, L., Hanchard, N., Arning, E., Bottiglieri, T., Maleta, K., Manary, M., Jahoor, F. 2022. One-carbon metabolism in children with marasmus and kwashiorkor. EBioMedicine. 75. Article 103791. https://doi.org/10.1016/j.ebiom.2021.103791.

Community-based management of acute malnutrition for infants under 6 months of age is safe and effective: Analysis of operational data - (Peer Reviewed Journal)
Woeltje, M.M., Evanoff, A.B., Helmink, B.A., Culbertson, D.L., Maleta, K.M., Manary, M.J., Trehan, I. 2021. Community-based management of acute malnutrition for infants under 6 months of age is safe and effective: Analysis of operational data. Public Health Nutrition. 26:246-255. https://doi.org/10.1017/S1368980021004894.

Management of uncomplicated severe acute malnutrition in children in resource-limited countries - (Book / Chapter)
Trehan, I., Manary, M.J. 2021. Management of uncomplicated severe acute malnutrition in children in resource-limited countries. UpToDate. Available at: https://www.uptodate.com/contents/management-of-uncomplicated-severe-acute-malnutrition-in-children-in-resource-limited-countries

Low linoleic acid foods with added DHA given to Malawian children with severe acute malnutrition improve cognition: A randomized, triple-blinded, controlled clinical trial - (Peer Reviewed Journal)
Stephenson, K., Callaghan-Gillespie, M., Maleta, K., Nkhoma, M., George, M., Park, H., Lee, R., Humphries-Cuff, I., Lacombe, R., Wegner, D., Canfield, R., Brenna, J., Manary, M. 2021. Low linoleic acid foods with added DHA given to Malawian children with severe acute malnutrition improve cognition: A randomized, triple-blinded, controlled clinical trial. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqab363.

United States healthcare burden of pediatric functional gastrointestinal pain disorder hospitalizations from 2002 to 2018 - (Peer Reviewed Journal)
Hollier, J.M., Salemi, J.L., Shulman, R.J. 2021. United States healthcare burden of pediatric functional gastrointestinal pain disorder hospitalizations from 2002 to 2018. Neurogastroenterology & Motility. 34(7). Article e14288. https://doi.org/10.1111/nmo.14288.

Fecal microbiota transplantation commonly failed in children with co-morbidities - (Peer Reviewed Journal)
Kellermayer, R., Wu, Q., Nagy-Szakal, D., Queliza, K., Ihekweazu, F.D., Bocchini, C.E., Magee, A.R., Oezguen, N., Spinler, J.K., Hollister, E.B., Shulman, R.J., Versalovic, J., Luna, R., Savidge, T.C. 2022. Fecal microbiota transplantation commonly failed in children with co-morbidities. Journal of Pediatric Gastroenterology and Nutrition. 74(2):227-235. https://doi.org/10.1097/MPG.0000000000003336.

Randomised trial: Peppermint oil (menthol) pharmacokinetics in children and effects on gut motility in children with functional abdominal pain - (Peer Reviewed Journal)
Shulman, R.J., Chumpitazi, B.P., Abdel-Rahman, S.M., Garg, U., Musaad, S., Kearns, G.L. 2021. Randomised trial: Peppermint oil (menthol) pharmacokinetics in children and effects on gut motility in children with functional abdominal pain. British Journal Of Clinical Pharmacology. 88:1321-1333. https://doi.org/10.1111/bcp.15076.

Prevalence and clinical correlates of antinuclear antibody in patients with gastroparesis - (Peer Reviewed Journal)
Parkman, H.P., Van Natta, M.L., Makol, A., Grover, M., Mccallum, R.W., Malik, Z., Koch, K.L., Sarosiek, I., Kuo, B., Shulman, R.J., Farrugia, G., Miriel, L., Tonascia, J., Hamilton, F., Pasricha, P.J., Abell, T.L. 2021. Prevalence and clinical correlates of antinuclear antibody in patients with gastroparesis. Neurogastroenterology & Motility. 34(5):e14270. https://doi.org/10.1111/nmo.14270.

Probiotic VSL#3 treatment reduces colonic permeability and abdominal pain symptoms in patients with irritable bowel syndrome - (Peer Reviewed Journal)
Boonma, P., Shapiro, J.M., Hollister, E.B., Badu, S., Wu, Q., Weidler, E.M., Abraham, B.P., Devaraj, S., Luna, R., Versalovic, J., Heitkemper, M.M., Savidge, T.C., Shulman, R.J. 2021. Probiotic VSL#3 treatment reduces colonic permeability and abdominal pain symptoms in patients with irritable bowel syndrome. Frontiers in Pain Research. 2. Article 691689. https://doi.org/10.3389/fpain.2021.691689.

Animal source foods, rich in essential amino acids, are important for linear growth and development of young children in low- and middle-income countries - (Review Article)
Parikh, P., Semba, R., Manary, M., Swaminathan, S., Udomkesmalee, E., Bos, R., Poh, B., Rojroongwasinkul, N., Geurts, J., Sekartini, R., Nga, T. 2021. Animal source foods, rich in essential amino acids, are important for linear growth and development of young children in low- and middle-income countries. Maternal and Child Nutrition. 18(1). Article e13264. https://doi.org/10.1111/mcn.13264.

Host fecal mRNAs predicted environmental enteric dysfunction among children with moderate acute malnutrition in Sierra Leone - (Peer Reviewed Journal)
Singh, A., Potani, I., Griswold, S.P., Suri, D., Langlois, B., Shen, Y., Walton, S.M., Kwan Ho Chui, K., Manary, M.J., Webb, P., Rogers, B.L., Rosenberg, I.H. 2021. Host fecal mRNAs predicted environmental enteric dysfunction among children with moderate acute malnutrition in Sierra Leone. American Journal of Tropical Medicine and Hygiene. 105(5):1376-1382. https://doi.org/10.4269/ajtmh.21-0348.

Undernutrition in pregnancy: Evaluation, management, and outcome in resource-limited areas - (Book / Chapter)
Hendrixson, T., Manary, M.J., Trehan, I., Wall, L.L. 2021. Undernutrition in pregnancy: Evaluation, management, and outcome in resource-limited areas. UpToDate. Available at: https://www.uptodate.com/contents/undernutrition-in-pregnancy-evaluation-management-and-outcome-in-resource-limited-areas

Reply to Verhoef et al - (Other)
Sorkin, J.D., Manary, M., Smeets, P.A., Macfarlane, A.J., Astrup, A., Prigeon, R.L., Hogans, B.B., Odle, J., Davis, T.A., Tucker, K.L., Duggan, C.P., Tobias, D.K. 2022. Reply to Verhoef et al. American Journal of Clinical Nutrition. 115(2):598-600. https://doi.org/10.1093/ajcn/nqab371.

Gastric accommodation: Physiology, diagnostic modalities, clinical relevance, and therapies - (Review Article)
Febo-Rodriquez, L., Chumpitazi, B.P., Sher, A.C., Shulman, R.J. 2021. Gastric accommodation: Physiology, diagnostic modalities, clinical relevance, and therapies. Neurogastroenterology & Motility. 33(12). Article e14213. https://doi.org/10.1111/nmo.14213.

Multisite pain is highly prevalent in children with functional abdominal pain disorders and is associated with increased morbidity - (Peer Reviewed Journal)
Chumpitazi, B.P., Palermo, T.M., Hollier, J.M., Self, M.M., Czyzewski, D., Weidler, E.M., Heitkemper, M., Shulman, R.J. 2021. Multisite pain is highly prevalent in children with functional abdominal pain disorders and is associated with increased morbidity. Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2021.04.059

Assessment of the gut bacterial microbiome and metabolome of girls and women with Rett Syndrome - (Peer Reviewed Journal)
Thapa, S., Venkatachalam, A., Khan, N., Naqvi, M., Balderas, M., Runge, J.K., Haag, A., Hoch, K.M., Glaze, D.G., Luna, R.A., Motil, K.J. 2021. Assessment of the gut bacterial microbiome and metabolome of girls and women with Rett Syndrome. PLoS ONE. 16(5):e0251231. https://doi.org/10.1371/journal.pone.0251231.

A novel intervention combining supplementary food and infection control measures to improve birth outcomes in undernourished pregnant women in Sierra Leone: A randomized,controlled clinical effectiveness trial - (Peer Reviewed Journal)
Hendrixson, D.T., Smith, K., Lasowski, P., Callaghan-Gillespie, M., Weber, J., Papathakis, P., Iversen, P., Koroma, S., Manary, M.J. 2021. A novel intervention combining supplementary food and infection control measures to improve birth outcomes in undernourished pregnant women in Sierra Leone: A randomized, controlled clinical effectiveness trial. PLoS Medicine. https://doi.org/10.1371/journal.pmed.1003618.

A novel intervention combining supplementary food and infection control measures to improve birth outcomes in undernourished pregnant women in Sierra Leone: A randomized, controlled clinical effectiveness trial - (Peer Reviewed Journal)

Effectiveness and cost-effectiveness of 4 supplementary foods for treating moderate acute malnutrition: Results from a cluster-randomized intervention trial in Sierra Leone - (Peer Reviewed Journal)
Griswold, S.P., Langlois, B.K., Shen, Y., Cliffer, I.R., Suri, D.J., Walton, S., Chui, K., Rosenberg, I.H., Koroma, A.S., Wegner, D., Hassan, A., Manary, M.J., Vosti, S.A., Webb, P., Rogers, B.L. 2021. Effectiveness and cost-effectiveness of 4 supplementary foods for treating moderate acute malnutrition: Results from a cluster-randomized intervention trial in Sierra Leone. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqab140.

Treating high-risk moderate acute malnutrition using therapeutic food compared with nutrition counseling (Hi-MAM Study): A cluster-randomized controlled trial - (Peer Reviewed Journal)
Lelijveld, N., Godbout, C., Krietemeyer, D., Los, A., Wegner, D., Hendrixson, D.T., Bandsma, R., Koroma, A., Manary, M. 2021. Treating high-risk moderate acute malnutrition using therapeutic food compared with nutrition counseling (Hi-MAM Study): A cluster-randomized controlled trial. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqab137.

PedsQL(TM) gastroparesis symptoms module domain and item development: Qualitative methods - (Peer Reviewed Journal)
Varni, J.W., Shulman, R.J., Self, M.M., Febo-Rodriguez, L., Charron, H., Williams, K., Nurko, S., Rosen, R.L., Chumpitazi, B.P. 2021. PedsQL(TM) gastroparesis symptoms module domain and item development: Qualitative methods. Journal of Pediatric Gastroenterology and Nutrition. 73(2):192-196. https://doi.org/10.1097/MPG.0000000000003146.

Effect of domperidone therapy on gastroparesis symptoms results of a dynamic cohort study by NIDDK Gastroparesis Consortium - (Peer Reviewed Journal)
Sarosiek, I., Van Natta, M., Parkman, H.P., Abell, T., Koch, K.L., Kuo, B., Shulman, R.J., Farrugia, G., Grover, M., Hamilton, F.A., Pasricha, P.J., Yates, K.P., Miriel, L., Wilson, L., Yamada, G., Tonascia, J., Mccallum, R.W. 2021. Effect of domperidone therapy on gastroparesis symptoms results of a dynamic cohort study by NIDDK Gastroparesis Consortium. Clinical Gastroenterology and Hepatology. 20:e452-e464. https://doi.org/10.1016/j.cgh.2021.05.063.

Clinical characterization of pediatric gastroparesis using a four-hour gastric emptying scintigraphy standard - (Peer Reviewed Journal)
Wolfson, S., Wilhelm, Z., Opekun, A.R., Orth, R., Shulman, R.J., Chumpitazi, B.P. 2021. Clinical characterization of pediatric gastroparesis using a four-hour gastric emptying scintigraphy standard. Journal of Pediatric Gastroenterology and Nutrition. 72(6): 848-853. https://doi.org/10.1097/MPG.0000000000003089.

Functional dyspepsia and gastroparesis in tertiary care are interchangeable syndromes with common clinical and pathologic features - (Peer Reviewed Journal)
Pasricha, P.J., Grover, M., Yates, K.P., Abell, T.L., Bernard, C.E., Koch, K.L., McCallum, R.W., Sarosiek, I., Kuo, B., Bulat, R., Chen, J., Shulman, R.J., Lee, L., Tonascia, J., Miriel, L.A., Hamilton, F., Farrugia, G., Parkman, H.P. 2021. Functional dyspepsia and gastroparesis in tertiary care are interchangeable syndromes with common clinical and pathologic features Gastroenterology. 160(6):2006-2017. https://doi.org/10.1053/j.gastro.2021.01.230

An optimized dose of therapeutic feeding results in noninferior growth in midupper arm circumference compared with a standard dose in children in Sierra Leone recovering from acute malnutrition - (Peer Reviewed Journal)
Stephenson, K.B., Agapova, S.E., Hendrixson, D., Koroma, A., Manary, M.J. 2021. An optimized dose of therapeutic feeding results in noninferior growth in midupper arm circumference compared with a standard dose in children in Sierra Leone recovering from acute malnutrition. Current Developments in Nutrition. 5(2):nzab007. https://doi.org/10.1093/cdn/nzab007.

Factors that contribute to the impairment of quality of life in gastroparesis - (Peer Reviewed Journal)
Parkman, H.P., Wilson, L.A., Yates, K.P., Koch, K.L., Abell, T.L., McCallum, R.W., Sarosiek, I., Kuo, B., Malik, Z., Schey, R., Shulman, R.J., Grover, M., Farrugia, G., Miriel, L., Tonascia, J., Hamilton, F., Pasricha, P.J., For the NIDDK/NIH Clinical Gastroparesis Consortium. 2021. Factors that contribute to the impairment of quality of life in gastroparesis. Neurogastroenterology & Motility. https://doi.org/10.1111/nmo.14087.

Management of complicated severe acute malnutrition in children in resource-limited countries - (Book / Chapter)
Trehan, I., Manary, M.J. 2021. Management of complicated severe acute malnutrition in children in resource-limited countries. UpToDate. Available at: https://www.uptodate.com/contents/management-of-complicated-severe-acute-malnutrition-in-children-in-resource-limited-countries

Meal induced symptoms in children with dyspepsia-relationships to sex and the presence of gastroparesis - (Peer Reviewed Journal)
Febo-Rodriguez, L., Chumpitazi, B.P., Musaad, S., Sher, A.C., Shulman, R.J. 2021. Meal induced symptoms in children with dyspepsia-Relationships to sex and the presence of gastroparesis. Journal of Pediatrics. 231:117-123. https://doi.org/10.1016/j.jpeds.2020.12.048.

Biomarkers of environmental enteric dysfunction are differently associated with recovery and growth among children with moderate acute malnutrition in Sierra Leone - (Peer Reviewed Journal)
Singh, A., Ghosh, S., Ward, H., Manary, M.J., Rogers, B.L., Rosenberg, I.H. 2021. Biomarkers of environmental enteric dysfunction are differently associated with recovery and growth among children with moderate acute malnutrition in Sierra Leone. American Journal of Clinical Nutrition. 113:1556-1564. https://doi.org/10.1093/ajcn/nqaa434.

Fructan-sensitive children with irritable bowel syndrome have distinct gut microbiome signatures - (Peer Reviewed Journal)
Chumpitazi, B.P., Hoffman, K.L., Smith, D.P., McMeans, A.R., Musaad, S., Versalovic, J., Petrosino, J.F., Shulman, R.J. 2021. Fructan-sensitive children with irritable bowel syndrome have distinct gut microbiome signatures. Alimentary Pharmacology & Therapeutics. 53:499-509.

Relapse and regression to severe wasting in children under 5 years: A theoretical framework - (Review Article)
Schaefer, R., Mayberry, A., Briend, A., Manary, M., Walker, P., Stobaugh, H., Hanson, K., McGrath, M., Black, R. 2021. Relapse and regression to severe wasting in children under 5 years: A theoretical framework. Maternal and Child Nutrition. 17:e13107. https://doi.org/10.1111/mcn.13107.

The effect of bovine colostrum/egg supplementation compared with corn/soy flour in young Malawian children: A randomized, controlled clinical trial - (Peer Reviewed Journal)
Bierut, T., Duckworth, L., Grabowsky, M., Ordiz, M., Laury, M.L., Callaghan-Gillespie, M., Maleta, K., Manary, M.J. 2020. The effect of bovine colostrum/egg supplementation compared with corn/soy flour in young Malawian children: A randomized, controlled clinical trial. American Journal of Clinical Nutrition. 113(2):420-427. https://academic.oup.com/ajcn/article/113/2/420/6040576.

Paediatric functional abdominal pain disorders - (Review Article)
Thapar, N., Benninga, M.A., Crowell, M.D., Di Lorenzo, C., Mack, I., Nurko, S., Saps, M., Shulman, R.J., Szajewska, H., Van Tilburg, M.A., Enck, P. 2020. Paediatric functional abdominal pain disorders. Nature Review Disease Primers. 6. Artticle 89. https://doi.org/10.1038/s41572-020-00222-5.

A roadmap to reduce stunting - (Review Article)
Roediger, R., Hendrixson, D., Manary, M.J. 2020. A roadmap to reduce stunting. American Journal of Clinical Nutrition. 112(2):773S-776S. https://doi.org/10.1093/ajcn/nqaa205.

Constipation in patients with symptoms of gastroparesis: Analysis of symptoms and gastrointestinal transit - (Peer Reviewed Journal)
Parkman, H.P., Sharkey, E., McCallum, R.W., Hasler, W.L., Koch, K.L., Sarosiek, I., Abell, T.L., Kuo, B., Shulman, R.J., Grover, M., Farrugia, G., Schey, R., Tonascia, J., Hamilton, F., Pasricha, P.J. 2020. Constipation in patients with symptoms of gastroparesis: Analysis of symptoms and gastrointestinal transit. Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2020.10.045.

A simplified, combined protocol versus standard treatment for acute malnutrition in children 6–59 months (ComPAS trial): A cluster-randomized controlled non-inferiority trial in Kenya and South Sudan - (Peer Reviewed Journal)
Bailey, J., Opondo, C., Lelijveld, N., Marron, B., Onyo, P., Musyoki, E.N., Adongo, S.W., Manary, M., Briend, A., Kerac, M. 2020. A simplified, combined protocol versus standard treatment for acute malnutrition in children 6–59 months (ComPAS trial): A cluster-randomized controlled non-inferiority trial in Kenya and South Sudan. PLoS Medicine. https://doi.org/10.1371/journal.pmed.1003192.

Activation of the innate immune system in children with irritable bowel syndrome evidenced by increased fecal human B-defensin-2 - (Peer Reviewed Journal)
Shulman, R.J., Devaraj, S., Heitkemper, M. 2020. Activation of the innate immune system in children with irritable bowel syndrome evidenced by increased fecal human B-defensin-2. Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2020.09.034.

Epidermal growth factor stimulates fatty acid synthesis mainly via PLC-y1/Akt signaling pathway in dairy goat mammary epithelial cell - (Peer Reviewed Journal)
Huang, J., Dai, B., Qu, H., Zhong, Y., Ma, Y., Luo, J., Hadsell, D., Shi, H. 2020. Epidermal growth factor stimulates fatty acid synthesis mainly via PLC-y1/Akt signaling pathway in dairy goat mammary epithelial cell. Animals. 10(6):930. https://doi.org/10.3390/ani10060930.

Growth velocity in children with environmental enteric dysfunction is associated with specific bacterial and viral taxa of the gastrointestinal tract in Malawian children - (Peer Reviewed Journal)
Desai, C., Handley, S., Rodgers, R., Rodriguez, C., Ordiz, M.I., Manary, M.J., Holtz, L.R. 2020. Growth velocity in children with environmental enteric dysfunction is associated with specific bacterial and viral taxa of the gastrointestinal tract in Malawian children. PLOS Neglected Tropical Diseases. 14(6):e0008387. https://doi.org/10.1371/journal.pntd.0008387.

Protein quality in ready-to-use supplementary foods for moderate wasting - (Peer Reviewed Journal)
Roediger, R., Stein, H.H., Callaghan-Gillespie, M., Blackman, J.K., Kohlmann, K., Maleta, K., Manary, M. 2020. Protein quality in ready-to-use supplementary foods for moderate wasting. Maternal and Child Nutrition. e13019. https://doi.org/10.1111/mcn.13019.

Partial leptin deficiency confers resistance to diet-induced obesity in mice - (Peer Reviewed Journal)
Zhao, S., Li, N., Zhu, Y., Straub, L., Zhang, Z., Wang, M., Zhu, Q., Kusminski, C.M., Elmquist, J.K., Scherer, P.E. 2020. Partial leptin deficiency confers resistance to diet-induced obesity in mice. Molecular Metabolism. 37:100995. https://doi.org/10.1016/j.molmet.2020.100995.

Co-occurrence of campylobacter species in children from Eastern Ethiopia, and their association with environmental enteric dysfunction, diarrhea, and host microbiome - (Peer Reviewed Journal)
Terefe, Y., Deblais, L., Ghanem, M., Helmy, Y.A., Mummed, B., Chen, D., Singh, N., Ahyong, V., Kalantar, K., Yimer, G., Hassen, J.Y., Mohammed, A., McKune, S.L., Manary, M.J., Ordiz, M.I., Gebreyes, W., Havelaar, A.H., Rajashekara, G. 2020. Co-occurrence of campylobacter species in children from Eastern Ethiopia, and their association with environmental enteric dysfunction, diarrhea, and host microbiome. Frontiers in Public Health. 8:99. https://doi.org/10.3389/fpubh.2020.00099.

Circulating insulin-like growth factor-1 is positively associated with growth and cognition in 6- to 9-year-old schoolchildren from Ghana - (Peer Reviewed Journal)
Grenov, B., Larnkjaer, A., Lee, R., Serena, A., Molgaard, C., Michaelsen, K.F., Manary, M.J. 2020. Circulating insulin-like growth factor-1 is positively associated with growth and cognition in 6- to 9-year-old schoolchildren from Ghana. Journal of Nutrition. 150(6):1405-1412. https://doi.org/10.1093/jn/nxaa075.

Acute malnutrition recovery energy requirements based on mid-upper arm circumference: Secondary analysis of feeding program data from 5 countries, Combined Protocol for Acute Malnutrition Study (ComPAS) Stage 1 - (Peer Reviewed Journal)
Chase, R.P., Kerac, M., Grant, A., Manary, M., Briend, A., Opondo, C., Bailey, J. 2020. Acute malnutrition recovery energy requirements based on mid-upper arm circumference: Secondary analysis of feeding program data from 5 countries, Combined Protocol for Acute Malnutrition Study (ComPAS) Stage 1. PLoS One. 15(6):e0230452. https://doi.org/10.1371/journal.pone.0230452.

Treatment of severe acute malnutrition with oat or standard ready-to-use therapeutic food: A triple-blind, randomised controlled clinical trial - (Peer Reviewed Journal)
Hendrixson, D.T., Godbout, C., Los, A., Callaghan-Gillespie, M., Mui, M., Wegner, D., Bryant, T., Koroma, A., Manary, M.J. 2020. Treatment of severe acute malnutrition with oat or standard ready-to-use therapeutic food: A triple-blind, randomised controlled clinical trial. Gut. https://doi.org/10.1136/gutjnl-2020-320769.

The effect of legume supplementation on the gut microbiota in rural Malawian infants aged 6 to 12 months - (Peer Reviewed Journal)
Ordiz, M.I., Janssen, S., Humphrey, G., Ackermann, G., Stephenson, K., Agapova, S., Divala, O., Kaimila, Y., Maleta, K., Zhong, C., Knight, R., Trehan, I., Tarr, P.I., Rusconi, B., Manary, M.J. 2020. The effect of legume supplementation on the gut microbiota in rural Malawian infants aged 6 to 12 months. American Journal of Clinical Nutrition. 111(4):884-892. https://doi.org/10.1093/ajcn/nqaa011.

Treatment of child wasting: Results of a child health and nutrition research initiative (CHNRI) prioritisation exercise - (Review Article)
Angood, C., Kerac, M., Black, R., Briend, A., Hanson, K., Jarrett, S., Manary, M., McGrath, M., Zagre, N., Lelijveld, N., Mayberry, A., CHNRI collaborators, Council of Research & Technical Advice on Acute Malnutrition (CORTASAM). 2021. Treatment of child wasting: Results of a child health and nutrition research initiative (CHNRI) prioritisation exercise. F1000Research. 10. Article 126. https://doi.org/10.12688/f1000research.46544.1.

Does a minority of children with functional gastrointestinal disorders receive formal diet advice - (Peer Reviewed Journal)
Cruz, L.A., Minard, C., Guffey, D., Chumpitazi, B.P., Shulman, R.J. 2020. Does a minority of children with functional gastrointestinal disorders receive formal diet advice?. Journal of Parenteral and Enteral Nutrition. https://doi.org/10.1002/jpen.1771.

Edematous severe acute malnutrition is characterized by hypomethylation of DNA - (Peer Reviewed Journal)
Schulze, K.V., Swaminathan, S., Howell, S., Jajoo, A., Lie, N.C., Brown, O., Sadat, R., Hall, N., Marshall, K., May, T., Reid, M.E., Taylor-Bryan, C., Wang, X., Belmont, J.W., Guan, Y., Manary, M.J., Trehan, I., McKenzie, C.A., Hanchard, N.A. 2019. Edematous severe acute malnutrition is characterized by hypomethylation of DNA. Nature Communications 10(1):5791 https://doi.org/10.1038/s41467-019-13433-6

Gut permeability is affected by sex and increased in children with irritable bowel syndrome but not in functional abdominal pain - (Peer Reviewed Journal)
Shulman, R.J., Devaraj, S., Heitkemper, M. 2019. Gut permeability is affected by sex and increased in children with irritable bowel syndrome but not in functional abdominal pain. Neurogastroenterology & Motility. 32(3):e13765. https://doi.org/10.1111/nmo.13765.

Effect of native and acetylated dietary resistant starches on intestinal fermentative capacity of normal and stunted children in Southern India - (Peer Reviewed Journal)
Balamurugan, R., Pugazhendhi, S., Balachander, G.M., Dharmalingam, T., Mortimer, E.K., Gopalsamy, G.L., Woodman, R.J., Meng, R., Alpers, D.H., Manary, M., Binder, H.J., Brown, I.L., Young, G.P., Ramakrishna, B.S. 2019. Effect of native and acetylated dietary resistant starches on intestinal fermentative capacity of normal and stunted children in Southern India. International Journal of Environmental Research and Public Health. 16(20):3922. https://doi.org/10.3390/ijerph16203922.

Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue - (Peer Reviewed Journal)
Song, A., Dai, W., Jang, M., Medrano, L., Li, Z., Zhao, H., Shao, M., Tan, J., Li, A., Ning, T., Miller, M.M., Armstrong, B., Huss, J.M., Zhu, Y., Liu, Y., Gradinaru, V., Wu, X., Jiang, L., Scherer, P.E., Wang, Q.A. 2019. Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue. Journal of Clinical Investigation. 130(1):247-257. https://doi.org/10.1172/JCI129167.

Serum amino acid concentrations in infants from Malawi are associated with linear growth - (Peer Reviewed Journal)
Ordiz, M.I., Semba, R.D., Moaddel, R., Rolle-Kampczyk, U., Von Bergen, M., Herberth, G., Khadeer, M., Roder, S., Manary, M.J. 2019. Serum amino acid concentrations in infants from Malawi are associated with linear growth. Current Developments in Nutrition. 3(10):nzz100. https://doi.org/10.1093/cdn/nzz100.

Proteomics in gastroparesis: Unique and overlapping protein signatures in diabetic and idiopathic gastroparesis - (Peer Reviewed Journal)
Grover, M., Dasari, S., Bernard, C.E., Chikkamenahalli, L.L., Yates, K.P., Pasricha, P.J., Sarosiek, I., McCallum, R., Koch, K.L., Abell, T.L., Kuo, B., Shulman, R.J., Gibbons, S.J., McKenzie, T.J., Kellogg, T.A., Kendrick, M.L., Tonascia, J., Hamilton, F.A., Parkman, H.P., Farrugia, G. 2019. Proteomics in gastroparesis: Unique and overlapping protein signatures in diabetic and idiopathic gastroparesis. American Journal of Physiology - Gastrointestinal and Liver Physiology. 317(5):G716-G726. https://doi.org/10.1152/ajpgi.00115.2019.

Increased gut permeability in first-degree relatives of children with irritable bowel syndrome or functional abdominal pain - (Peer Reviewed Journal)
McOmber, M., Rafati, D., Cain, K., Devaraj, S., Weidler, E.M., Heitkemper, M., Shulman, R.J. 2020. Increased gut permeability in first-degree relatives of children with irritable bowel syndrome or functional abdominal pain. Clinical Gastroenterology and Hepatology. 18(2):375-384. https://doi.org/10.1016/j.cgh.2019.05.011

Ready-to-use supplemental food for nutritional supplementation in cystic fibrosis - (Peer Reviewed Journal)
Pitman, R.T., Mui, M., Michelson, P.H., Manary, M.J. 2019. Ready-to-use supplemental food for nutritional supplementation in cystic fibrosis. Current Developments in Nutrition. 3(5):nzz016. https://doi.org/10.1093/cdn/nzz016.

Role of optimized plant protein combinations as a low-cost alternative to dairy ingredients in foods for prevention and treatment of moderate acute malnutrition and severe acute malnutrition - (Peer Reviewed Journal)
Manary, M., Callaghan-Gillespie, M. 2020. Role of optimized plant protein combinations as a low-cost alternative to dairy ingredients in foods for prevention and treatment of moderate acute malnutrition and severe acute malnutrition. Nestle Nutrition Workshop. 93:111-120. https://doi.org/10.1159/000503347.

Assessment of quality and readability of internet dietary information on irritable bowel syndrome - (Review Article)
Alfaro-Cruz, L., Kaul, I., Zhang, Y., Shulman, R.J., Chumpitazi, B.P. 2019. Assessment of quality and readability of internet dietary information on irritable bowel syndrome. Clinical Gastroenterology and Hepatology. 17(3):566-567. https://doi.org/10.1016/j.cgh.2018.05.018.