Research Project: Exploiting Nutrition and Protein Quality Controls to Delay Age-related Macular Degeneration and Cataracts

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short and long-term dietary hyperglycemia - (Peer Reviewed Journal)
Mondal, A.K., Brock, D.C., Rowan, S., Yang, Z., Rojulpote, K.V., Smith, K.M., Francisco, S.G., Bejarano-Fernandez, E., English, M., Deik, A., Jeanfavre, S., Clish, C.B., Remaley, A.T., Taylor, A., Swaroop, A. 2024. Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short and long-term dietary hyperglycemia. iScience. https://doi.org/10.1016/j.isci.2024.108979.

Unbalanced redox status network as an early pathological event in congenital cataracts - (Peer Reviewed Journal)
Bejarano, E., Whitcomb, E., Pfeiffer, R.L., Rose, K.L., Asensio, M.J., Rodriguez-Navarro, J.A., Ponce-Mora, A., Canto, A., Almansa, I., Schey, K.L., Jones, B.W., Taylor, A., Rowan, S. 2023. Unbalanced redox status network as an early pathological event in congenital cataracts. Redox Biology. https://doi.org/10.1016/j.redox.2023.102869.

Redox regulation in age-related cataracts: roles for glutathione, vitamin C, and the NRF2 signaling pathway - (Review Article)
Bejarano-Fernandez, E., Weinberg, J., Clark, M., Taylor, A., Rowan, S., Whitcomb, E. 2023. Redox regulation in age-related cataracts: roles for glutathione, vitamin C, and the NRF2 signaling pathway. Nutrients. https://doi.org/ 10.3390/nu15153375.

Repurposing a cyclin dependent kinase 1 (CDK1) mitotic regulatory network to complete terminal differentiation in lens fiber cells - (Peer Reviewed Journal)
Taylor, A., Gu, Y., Chang, M., Yang, W., Francisco, S., Rowan, S., Bejarano, E., Pruitt, S., Zhu, L., Weiss, G., Brennan, L., Kantorow, M., Whitcomb, E. 2023. Repurposing a cyclin dependent kinase 1 (CDK1) mitotic regulatory network to complete terminal differentiation in lens fiber cells. Investigative Ophthalmology and Visual Science. 64(2). https://doi.org/10.1167/iovs.64.2.6.

Proteostasis in aging-associated ocular disease - (Review Article)
Weinberg, J., Gaur, M., Swaroop, A., Taylor, A. 2022. Proteostasis in aging-associated ocular disease. Molecular Aspects of Medicine. https://doi.org/10.1016/j.mam.2022.101157.

Inside out: relations between the microbiome, nutrition, and eye health - (Review Article)
Grant, M.B., Bernstein, P.S., Boesze-Battaglia, K., Chew, E.0., Curcio, C.A., Kenney, M.C., Klaver, C., Philp, N., Rowan, S., Sparrow, J., Spaide, R.F., Taylor, A. 2022. Inside out: relations between the microbiome, nutrition, and eye health. Experimental Eye Research. https://doi.org/10.1016/j.exer.2022.109216.

Aged Nrf2-null mice develop all major types of age-related cataracts - (Peer Reviewed Journal)
Rowan, S., Jiang, S., Francisco, S., Pomatto, L., Ma, Z., Jiao, X., Campos, M., Aryal, S., Patel, S., Mahaling, B., Riazuddin, S.A., Duh, E., Lachke, S., Hejtmancik, J.F., De Cabo, R., Fitzgerald, P., Taylor, A. 2021. Aged Nrf2-null mice develop all major types of age-related cataracts. Investigative Ophthalmology and Visual Science. 62(15):10. https://doi.org/10.1167/iovs.62.15.10.

Boosting proteolytic pathways as a treatment against glycation-derived damage in the brain? - (Review Article)
Taylor, A., Bejarano-Fernandezel, E. 2021. Boosting proteolytic pathways as a treatment against glycation-derived damage in the brain? Neural Regeneration Research. 17(2):320-322. https://doi.org/10.4103/1673-5374.317971.

Alterations to the gut microbiome impair bone tissue strength in aged mice - (Peer Reviewed Journal)
Macy, C., Smith, K.M., Nixon, J.C., Hernandez, C.J., Rowan, S. 2021. Alterations to the gut microbiome impair bone tissue strength in aged mice. Bone Reports. 14:101065. https://doi.org/10.1016/j.bonr.2021.101065.

Glyoxalase system as a therapeutic target against diabetic retinopathy - (Review Article)
Aragones, G., Rowan, S., Francisco, S.G., Yang, W., Weinberg, J., Taylor, A., Bejarano, E. 2020. Glyoxalase system as a therapeutic target against diabetic retinopathy. Antioxidants. 9(11):1062. https://doi.org/10.3390/antiox9111062.

Generation and characterization of anti-glucosepane antibodies enabling direct detection of glucosepane in retinal tissue - (Peer Reviewed Journal)
Streeter, M.D., Rowan, S., Ray, J., McDonald, D.M., Volkin, J., Clark, J., Taylor, A., Spiegel, D.A. 2020. Generation and characterization of anti-glucosepane antibodies enabling direct detection of glucosepane in retinal tissue. ACS Chemical Biology. 15(10):2655-2661. https://doi.org/10.1021/acschembio.0c00093.

Dietary Patterns, Carbohydrates, and Age-Related Eye Diseases - (Review Article)
Francisco, S.G., Smith, K.M., Aragones, G., Whitcomb, E., Weinberg, J., Wang, X., Bejarano-Fernandez, E., Taylor, A., Rowan, S. 2020. Dietary patterns, carbohydrates, and age-related eye diseases. Nutrients. https://doi.org/10.3390/nu12092862.

Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability - (Peer Reviewed Journal)
Aragones, G., Dasuri, K., Olukorede, O., Francisco, S.G., Renneburg, C., Kumsta, C., Hansen, M., Kageyama, S., Komatsu, M., Rowan, S., Volkin, J., Workman, M., Yang, W., Daza, P., Ruano, D., Dominguez-Martin, H., Rodriguez-Navarro, J.A., Du, X., Brownlee, M.A., Bejarano, E., Taylor, A. 2020. Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability. Aging Cell. https://doi.org/10.1111/acel.13257.

Dietary starch composition effects on Cx43-intercellular communication channels and short-term memory - (Abstract Only)
Francisco, S., Smith, K., Rowan, S., Aragones Bargallo, G., Smith, D.E., Shukitt Hale, B., Taylor, A., Bejarano Fernandez, E. 2020. Dietary starch composition effects on Cx43-intercellular communication channels and short-term memory. Current Developments in Nutrition. 4(2):1205. https://doi.org/10.1093/cdn/nzaa057_021.

The interaction of gut microbiota composition and dietary starch form on gut health in aged mice - (Abstract Only)
2020. The interaction of gut microbiota composition and dietary starch form on gut health in aged mice. Current Developments in Nutrition. 4(Suppl_2):1585. https://doi.org/10.1093/cdn/nzaa062_042.

A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration - (Peer Reviewed Journal)
Rowan, S., Jiang, S., Chang, M., Volkin, J., Cassalman, C., Smith, K.M., Streeter, M.D., Spiegel, D.A., Moreira-Neto, C., Rabbani, N., Thornalley, P.J., Smith, D.E., Waheed, N.K., Taylor, A., Jiang, S. 2020. A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration. Free Radical Biology and Medicine. 150:75-86. https://doi.org/10.1016/j.freeradbiomed.2020.02.010.

Mechanistic targeting of advanced glycation end-products in age-related diseases - (Review Article)
Rowan, S., Bejarano-Fernandez, E., Taylor, A. 2018. Mechanistic targeting of advanced glycation end-products in age-related diseases. Biochimica et Biophysica Acta. 1864(12):3631-3643. https://doi.org/10.1016/j.bbadis.2018.08.036.